Ultrasound assisted transdermal vaccine delivery method and system
First Claim
1. A delivery system for delivering an immunologically active agent to a subject, comprising:
- a microprojection member having a plurality of stratum corneum-piercing microprojections;
a formulation having said immunologically active agent; and
an ultrasonic device adapted to apply ultrasonic energy to said subject.
1 Assignment
0 Petitions
Accused Products
Abstract
An apparatus and method for transdermally delivering a vaccine comprising a delivery system having (i) a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers and (ii) an ultrasonic device. In one embodiment, the vaccine is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having a vaccine-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the vaccine is contained in both the coating and the hydrogel formulation.
131 Citations
76 Claims
-
1. A delivery system for delivering an immunologically active agent to a subject, comprising:
-
a microprojection member having a plurality of stratum corneum-piercing microprojections;
a formulation having said immunologically active agent; and
an ultrasonic device adapted to apply ultrasonic energy to said subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
-
-
50. A method for transdermally delivering an immunologically active agent to a subject, comprising the steps of:
-
providing a microprojection delivery system, said delivery system including a microprojection member having a plurality of stratum corneum-piercing microprojections, a formulation including the immunologically active agent and an ultrasonic device;
applying said microprojection member to a desired location on said subject; and
transmitting ultrasonic energy from said ultrasonic device to said desired location on said subject to facilitate delivery of said immunologically active agent. - View Dependent Claims (51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76)
-
Specification