SKIN ADHERENT HYDROGELS
First Claim
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1. A composition comprising a hydrogel formed by a mixture of two or more of (1) a non-acidic poly(n-vinyl lactam) with a k value of at least 30 (2) a water soluble multifunctional amine-containing polymer and mixtures thereof or (3) a chitosan derivative or mixtures thereof.
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Abstract
There is disclosed hydrogel compositions comprising a combination of at least two of three components selected from non-acidic poly (N-vinyl lactam), chitosan derivatives and water-soluble multifunctional amine-containing polymers in various ratios. The hydrogels are useful as cavity-filling wound dressings, burn dressings, drug delivery systems, cosmetic masks, conductive electrodes, prostheses and wraps.
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109 Claims
- 1. A composition comprising a hydrogel formed by a mixture of two or more of (1) a non-acidic poly(n-vinyl lactam) with a k value of at least 30 (2) a water soluble multifunctional amine-containing polymer and mixtures thereof or (3) a chitosan derivative or mixtures thereof.
- 24. A composition comprising a hydrogel formed by a mixture of a non-acidic poly(N-vinyl lactam) with a K value of at least 30 at and a water soluble multifunctional amine-containing polymer.
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43. A composition comprising a non-acidic poly(N-vinyl lactam) with a K value of at least 30 and a multifunctional amine-containing polymer in a weight ratio of about 8.75 to 1.
- 44. (EXAMPLE 8) A composition formed by combining (a) an aqueous solution comprising non-acidic polyvinylpyrrolidone, lidocaine hydrogen chloride and glutaric dialdehyde in a weight ratio, respectively, of about 69.7 to 12 to 1 with (b) an aqueous solution comprising polyethyleneimine, glycerin and polyvinylpyrrolidone/dimethylaminoethyl-methacrylate copolymer in a weight ratio, respectively, of about 1.87 to 1.25 to 1 wherein the total weight of aqueous solution of each of (a) and (b) are in the range of about 0.9 to 1 respectively.
- 45. (EXAMPLE 7) A composition formed by combining (a) an aqueous solution comprising non-acidic polyvinylpyrrolidone, lidocaine hydrogen chloride and glutaric dialdehyde in a weight ratio, respectively, of about 68.2 to 16 to 1 with (b) an aqueous solution of comprising polyethyleneimine, glycerin and polyvinyl pyrrolidone/dimethylaminoethyl-methacrylate copolymer in a weight ratio, respectively, of about 1.85 to 1.25 to 1 wherein the total weight of the aqueous solution in each of (a) and (b) are in the range of about 1 to 1 respectively.
- 46. (EAMPLE 9) A composition formed by combining (a) an aqueous solution comprising non-acidic polyvinylpyrrolidone, polyethylene glycol, benzocaine and glutaric dialdehyde in a weight ratio respectively of about 56 to 34 to 14 to 1 with (b) an aqueous solution comprising polyethylene glycol, glycerin, benzocaine, polyvinyl pyrrolidone/dimethylaminoethyl-methacrylate copolymer and polyethyleneimine in the weight ratio respectively of about 5.5 to 2.5 to 2.5 to 2 to 1 wherein the total weight of each aqueous solution (a) and (b) is in the range of about 1 to 1.
- 47. A composition comprising a hydrogel formed by a mixture of a non-acidic poly(N-vinyl lactam) with a K value of at least 30 and a chitosan derivative or mixtures thereof.
- 71. A composition comprising a hydrogel formed by the mixture of a water soluble multifunctional amine-containing polymer and a chitosan derivative or mixtures thereof.
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107. A kit for a cosmetic gel comprising separate portions of a non-acidic poly(N-vinyl lactam) having a K value of at least 30 and a multifunctional amine-containing polymer selected from the group consisting of a multifunctional amine-containing polymer and a chitosan derivative and a separate portion containing cosmetic agents selected from the group consisting of hydrating agents, fragrances and skin nutrients with instructions as to the order of addition to and the amount of water in which to form a hydrogel, application and removal directions.
Specification