Dermatological composition

• US 20050112153A1
• Filed: 11/26/2003
• Published: 05/26/2005
• Est. Priority Date: 11/26/2003
• Status: Active Grant

• Current Assignee: EI, LLC (Steris PLC)
• Original Assignee: Harmony Labs Incorporated
• Inventors: Wagoner, Bruce Kevin
• Granted Patent: US 7,582,307 B2
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/28 Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61K 8/922 of vegetable origin
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 15/00 Anti-perspirants or body deodorants deodorisation of air A61L9/00
• CPC Class Codes: A61Q 3/00 Manicure or pedicure preparations

Abstract

Dermatological compositions containing a humectant, e.g., at least one of urea, ammonium lactate, and glycerin, and an emollient, e.g., at least one of Shea or cocoa butter, glycine soja sterol and hybrid sunflower oil. The compositions of the invention may be utilized for treatment or amelioration of skin disorders or adverse physiological conditions, and such compositions may be employed as a base for cosmetic or pharmaceutical formulations for dermal administration.

Claims

1. A dermatological composition comprising a humectant including at least one of urea, ammonium lactate, and glycerin, and at least one emollient selected from the group consisting of Butyrospernum Parkii (Shea butter) fruit, glycine soja (soybean) sterol and Helianthus Annuus (hybrid sunflower) oil.

2. A dermatological composition according to claim 1, comprising one of said emollients.

3. A dermatological composition according to claim 1, comprising two of said emollients.

4. A dermatological composition according to claim 1, comprising all three of said emollients.

5. A dermatological composition according to claim 1, wherein said humectant comprises urea.

6. A dermatological composition according to claim 1, wherein said humectant comprises ammonium lactate.

7. A dermatological composition according to claim 1, wherein said humectant comprises glycerin.

8. A dermatological composition according to claim 1, further comprising water.

9. A dermatological composition according to claim 1, in a form selected from the group consisting of lotions, creams, ointments, emulsions, suspensions, ointments and gels.

10. A dermatological composition according to claim 1, further comprising at least one additive selected from the group consisting of antioxidants, chelants, emulsifiers, thickeners, and pH adjustment agents.

11. A dermatological composition according to claim 1, having a pH in a range of from about 4 to about 10.

12. A dermatological composition according to claim 1, having a pH in a range of from about 7 to about 10.

13. A dermatological composition according to claim 1, having a pH in a range of from about 7.5 to about 9.

14. A dermatological composition according to claim 1, comprising the following components in the following respective concentration ranges:

15. A dermatological composition according to claim 14, wherein the concentration of urea is in a range of from about 5 to about 40 weight %.

16. A dermatological composition according to claim 14, wherein the concentration of urea is in a range of from about 21 to about 40 weight %.

17. A dermatological composition according to claim 1, comprising the following components in the following respective concentration ranges:

18. A dermatological composition according to claim 1, comprising the following components in the following respective concentrations:

19. A dermatological composition according to claim 1, comprising the following components in the following respective concentrations:

20. A dermatological composition according to claim 1, comprising from about 5 to about 40 percent by weight urea, from about 2 to about 10 percent by weight Shea butter, from about 1 to about 4 percent by weight glycine soja (soybean sterol), from about 2 to about 15 percent by weight Helianthus Annuus (hybrid sunflower) oil, and the balance being dermatologically acceptable excipients, wherein percent by weight is based on the total weight of the composition.

21. The composition of claim 20, further comprising between about 2 to about 10 percent by weight of an emulsifier, based on the total weight of the composition.

22. The composition of claim 20, wherein the emulsifier includes glyceryl stearate or a dermatologically acceptable stearate derivative.

23. The composition of claim 20, wherein the emulsifier includes stearic acid or a dermatologically acceptable salt thereof.

24. The composition of claim 20, further comprising from about 0.1 to about 1.5 percent by weight of a thickener, based on the total weight of the composition.

25. The composition of claim 24, wherein the thickener includes sodium polyacrylate.

26. The composition of claim 20, further comprising a pH adjusting agent.

27. The composition of claim 20, in the form of a lotion.

28. The composition of claim 20, in the form of a cream.

29. The composition of claim 20, further comprising at least one additive selected from the group consisting of enzymes, anti-inflammatory agents, and antimicrobial agents.

30. A dermatological composition according to claim 1, comprising:

(a) from about 1 to about 50 percent by weight urea;

(b) from about 2 to about 10 percent by weight Shea butter;

(c) from about 1 to about 4 percent by weight glycine soja (soybean) sterol;

(d) from about 2 to about 15 percent by weight of Helinthus annuus (hybrid sunflower) oil;

(e) from about 2 to about 10 percent by weight of an emulsifier;

(f) from about 0.1 to about 1.5 percent by weight of a thickener; and

(g) optionally, a pH adjusting agent, a chelating agent, an antioxidant, a preservative, water or a combination of water and a water-miscible solvent, or other dermatologically acceptable components, and/or mixtures thereof;

with the percentages by weight of all ingredients totaling to 100 weight percent.

31. A dermatological composition according to claim 1, comprising:

(a) from about 2 to about 15 percent ammonium lactate;

(b) from about 2 and 10 percent by weight Shea butter;

(c) from about 1 and 4 percent by weight glycine soja (soybean) sterol;

(d) from about 2 to about 15 percent by weight of Helinthus annuus (hybrid sunflower) oil;

(e) from about 2 to about 10 percent by weight of an emulsifier;

(f) from about 0.1 to about 1.5 percent by weight of a thickener; and

(g) optionally, a pH adjusting agent, a chelating agent, a preservative, an antioxidant, a preservative, water or a combination of water and a water-miscible solvent, or other dermatologically acceptable components, and/or mixtures thereof;

with the percentages by weight of all ingredients totaling to 100 weight percent.

35. A method of treating skin, tissue or nails, comprising application thereto of a composition as claimed in claim 1.

36. The method of claim 35, comprising cosmetic treatment.

37. The method of claim 35, comprising debriding skin, softening tissue, or softening nails.

38. The method of claim 35, comprising therapeutic treatment.

39. The method of claim 35, comprising treating skin for a condition selected from the group consisting of psoriasis, xerosis, ichthoyosis, keratosis, keratoderma, dermatitis, pruritis, eczema, and calluses.

32. A dermatological composition comprising a humectant including at least one of urea, ammonium lactate and glycerin, and an emollient including at least one of:

(i) Shea butter, cocoa butter, or vegetable oil butter;

(ii) plant-derived steroid alcohol and/or lecithin; and

(iii) oxidation-stable natural oil.

33. A dermatological composition according to claim 32, comprising urea, and at least one of (i) Shea or cocoa butter, (ii) glycine soja (soybean) sterol and (iii) Helianthus Annuus (hybrid sunflower) oil.

34. A dermatological composition according to claim 32, comprising ammonium lactate, and at least one of (i) Shea or cocoa butter, (ii) glycine soja (soybean) sterol and (iii) Helianthus Annuus (hybrid sunflower) oil.