In vivo synthesis of connective tissues
First Claim
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1. A composition construct that comprises precursor cells that are seeded in a biocompatible scaffold.
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Abstract
The in vivo synthesis of connective tissue by fibroblast or fibroblast precursor cells ensconced within a biocompatible scaffold is disclosed. The cells are preferably present in a biocompatible scaffold such as gelatin and placed between two other biocompatible scaffolds such as collagen sponges soaked with a collagenic amount of a member of the TGF-β family of proteins. This composition is then implanted in a host to produce cranial sutures, periodontal ligament or other fibrous tissue structures in vivo.
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Citations
19 Claims
- 1. A composition construct that comprises precursor cells that are seeded in a biocompatible scaffold.
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8. A composition that comprises precursor cells that are seeded in a biocompatible scaffold comprised of a gelatin layer sandwiched between two collagen sponge layers, wherein one or both collagen sponge layers contains an effective mount of a growth factor protein that is a member of the TGF-β
- family of proteins.
- View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16)
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17. A composition that comprises fibroblastic cells that are seeded in a biocompatible scaffold comprised of a gelatin layer that is sandwiched between two collagen sponge layers, wherein one or both collagen sponge layers contains a collagenic amount of a member of the TGF-β
- family of proteins.
Specification