Composition and dosage form comprising an amphiphilic molecule as a suspension vehicle
First Claim
Patent Images
1. A liquid composition in an osmotic drug delivery system comprising an amphiphilic molecule, a non-aqueous liquid solvent, and a pharmaceutically active agent.
10 Assignments
0 Petitions
Accused Products
Abstract
A liquid composition in an osmotic drug delivery system and a dosage form in an osmotic drug delivery system is disclosed comprising an amphiphilic molecule, a non-aqueous liquid solvent, and a pharmaceutically active agent.
-
Citations
83 Claims
- 1. A liquid composition in an osmotic drug delivery system comprising an amphiphilic molecule, a non-aqueous liquid solvent, and a pharmaceutically active agent.
-
21. A dosage form for osmotic drug delivery comprising:
-
a capsule including a first chamber containing a viscous liquid pharmaceutical composition and a second chamber containing an osmotic agent, said first chamber having an opening through which the pharmaceutical composition can be delivered from the first chamber to a location external of the first chamber;
a movable separating member positioned in the capsule between the first chamber and the second chamber;
a wall of the second chamber including a fluid permeable portion allowing fluid to pass from a surrounding environment into the second chamber; and
an incompressible fluid additive located within the second chamber and substantially surrounding the osmotic agent. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
-
- 44. A suspending vehicle in a pump-driven dosage form comprising an amphiphilic molecule, a non-aqueous solvent, and a performance modifier.
-
58. A method comprising:
-
identifying an amphiphilic molecule;
identifying a non-aqueous solvent;
identifying a performance modifier;
mixing the amphiphilic molecule, the non-aqueous solvent, and the performance modifier to create a suspending vehicle. - View Dependent Claims (59, 60, 61, 62, 63, 64, 65, 66, 67)
-
- 68. A suspension in a pump-driven dosage form comprising a pharmaceutically active agent suspended or dispersed in a suspending vehicle, wherein the suspending vehicle comprises an amphiphilic molecule, a non-aqueous solvent, and a performance modifier.
-
76. A dosage form comprising:
-
a first wall that maintains its physical and chemical integrity during the life of the dosage form and is substantially impermeable to a pharmaceutical suspension;
a second wall that is partially permeable to an exterior fluid;
a compartment defined by the first wall and the second wall;
a pharmaceutical suspension that is positioned within the compartment and comprises an amphiphilic molecule, a non-aqueous solvent, a performance modifier, and a pharmaceutically active agent; and
an exit port in the wall in communication with the compartment. - View Dependent Claims (77, 78, 79, 80, 81, 82, 83)
-
Specification