Drug delivery in association with medical or surgical procedures

• US 20050112325A1
• Filed: 10/12/2004
• Published: 05/26/2005
• Est. Priority Date: 06/03/1998
• Status: Abandoned Application

• Current Assignee: Scott Laboratories, Inc.
• Original Assignee: Scott Laboratories, Inc.
• Inventors: Hickle, Randall S.
• Application Number:
  US10/961,147
• Publication Number:
  US 20050112325A1
• Time in Patent Office: Days
• US Class Current: 428/141
• CPC Class Codes: A61B 5/1106 to assess neuromuscular blockade, e.g. to estimate depth of anaesthesia
• CPC Class Codes: A61B 5/162 Testing reaction times
• CPC Class Codes: A61B 5/417 the bone marrow
• CPC Class Codes: A61B 5/4821 Determining level or depth of anaesthesia A61B5/1106 takes precedence
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/0078 Breathing bags
• CPC Class Codes: A61M 16/0084 self-reinflatable by elasticity, e.g. resuscitation squeeze bags
• CPC Class Codes: A61M 16/009 Removing used or expired gases or anaesthetic vapours filtering, sterilising or disinfecting the exhaust air in drainage systems A61M1/784; bacterial filters in the expiratory path A61M16/1065
• CPC Class Codes: A61M 16/0093 by adsorption, absorption or filtration
• CPC Class Codes: A61M 16/01 specially adapted for anaesthetising A61M16/104, A61M16/18 take precedence
• CPC Class Codes: A61M 16/026 specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
• CPC Class Codes: A61M 16/1015 using a gas flush valve, e.g. oxygen flush valve
• CPC Class Codes: A61M 16/107 in the inspiratory path
• CPC Class Codes: A61M 19/00 Local anaesthesia syringes therefor A61M5/00; Hypothermia A61M5/42 takes precedence; cooling blood in a bypass of the arterial system A61M1/36
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2016/0036 in the breathing tube and used in both inspiratory and expiratory phase
• CPC Class Codes: A61M 2016/1025 the O2 concentration
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/276 preventing unwanted use
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2205/3379 : Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 2205/3561 : local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/505 : Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 2209/084 : Supporting bases, stands for equipment
• CPC Class Codes: A61M 2230/205 : partial oxygen pressure (P-O2)
• CPC Class Codes: A61M 2230/43 : Composition of exhalation
• CPC Class Codes: A61M 2230/432 : partial CO2 pressure (P-CO2)
• CPC Class Codes: G16H 20/17 : delivered via infusion or injection
• CPC Class Codes: G16H 40/63 : for local operation
• CPC Class Codes: Y10T 428/24355 : Continuous and nonuniform or irregular surface on layer or component [e.g., roofing, etc.]

Abstract

A care system and associated methods are provided for alleviating patient pain, anxiety and discomfort associated with medical or surgical procedures, the system comprising: at least one patient health monitor device coupled to a patient and generating a signal reflecting at least one physiological condition of the patient; a drug delivery controller supplying one or more drugs to the patient; a memory device storing a safety data set reflecting parameters of the at least one patient physiological condition; and an electronic controller interconnected between the patient health monitor, the drug delivery controller and the safety data set; wherein said electronic controller manages the application of the drugs in accord with the safety data set. In another aspect of the invention, the care system facilitates a procedural physician'"'"'s safely and efficaciously providing conscious sedation to a patient by additionally providing a consciousness monitoring-system which monitors the consciousness of the patient and generates a value representing the level of patient consciousness. Methods for alleviating patient pain and anxiety in accordance with the invention comprise connecting a drug delivery device to a patient, such device having a drug delivery controller supplying one or more drugs and being coupled to an electronic controller; attaching at least one patient health monitor device to the patient; accessing a memory device which stores a safety data set reflecting parameters of at least one patient physiological condition; and delivering the drugs to the patient in accord with the safety data set. In further aspects of the invention, the consciousness monitoring system is an automated consciousness monitoring system which includes patient query and response devices. Additional embodiments of the system and methods are directed to alleviating patient pain or discomfort while enabling safe patient controlled drug delivery in correlation with the monitoring of patient health conditions.

Claims

1-96. -96. (canceled)

97. A drug mixture suitable for use by a non-anesthetist medical person during the performance of a medical and/or surgical procedure for delivery to a patient via a delivery apparatus to provide effective sedation and pain management without general anesthesia to a non-intubated patient in need thereof, wherein said apparatus comprises a drug delivery device for delivering a dosage rate of said drug mixture to said patient during said procedure, at least one sensor coupled to said patient for providing feedback data of the ventilatory function of the lungs of the patient during said medical procedure, and a processor connected to said sensor and adapted to electronically receive said feedback data and to generate a signal reflecting the ventilatory status of the patient, said signal indicating possible modifications of said drug delivery to maintain proper ventilatory functions during said medical procedure, said drug mixture comprising:

an analgesic drug to provide pain relief for the non-intubated patient in need thereof during said procedure; and

a sedative drug to provide sedation for the non-intubated patient in need thereof during said procedure.

98. The drug mixture according to claim 97, wherein said analgesic drug is selected from the group consisting of fentanyl, remifentanil, morphine amd meperidine.

99. The drug mixture according to claim 98, wherein said sedative drug is propofol.

100. The drug mixture according to claim 97, wherein said analgesic drug is remifentanil.

101. The drug mixture according to claim 97, wherein said sedative drug is propofol.

102. The drug mixture according to claim 101, wherein said analgesic drug is remifentanil.

103. A drug mixture suitable for use by a non-anesthetist medical person during the performance of a medical and/or surgical procedure, said mixture providing effective sedation and pain management without general anesthesia to a non-intubated patient in need thereof, said mixture comprising:

an effective quantity of remifentanil to provide pain relief for the non-intubated patient in need thereof during said procedure; and

an effective quantity of propofol to provide sedation for the non-intubated patient in need therof during said procedure;

said drug mixture being combined prior to infusion into said patient and suitable for delivery to said patient to provide effective pain relief and sedation without placing the patient in a state of general anesthesia.

104. A drug mixture for use by a non-anesthetist personnel for performing a medical and/or surgical procedure on a spontaneously-ventilating patient in need of sedation and pain control during the procedure, said mixture comprising

a proportion of an analgesic sufficient to provide effective pain relief to the spontaneously ventilating patient during said procedure;

a proportion of a sedative sufficient to provide effective sedation to the spontaneously ventilating patient during said procedure;

said sedative and said analgesic mixture being ready for infusion by an electronically controlled infusion pump during said procedure.

105. The drug mixture according to claim 104, wherein said analgesic is selected from the group consisting of fentanyl, remifentanil, morphine and meperidine.

106. The drug mixture according to claim 105, wherein said sedative is propofol.

107. The drug mixture according to claim 104, wherein said analgesic is remifentanil.

108. The drug mixture according to claim 104, wherein said sedative is propofol.

109. The drug mixture according to claim 108, wherein said analgesic is remifentanil.

110. A drug mixture for use during a medical and/or surgical procedure, said mixture comprising

a quantity of remifentenal sufficient to provide effective pain relief to a patient the during said procedure;

a quantity of propofol sufficient to provide effective sedation to a patient during said procedure;

said propofol and said remifentenal being mixed for infusion by an electronically controlled infusion pump during said procedure.