Fiber optic device for sensing analytes
First Claim
1. A device for sensing a target analyte in a sample comprising:
- an optical conduit having a proximal end and a distal end;
an optical system at the proximal end of the optical conduit comprising at least one electromagnetic energy emitter and at least one electromagnetic energy detector; and
a sensing element in optical proximity to the distal end of the optical conduit comprising at least one binding protein adapted to bind with at least one target analyte and at least one reporter group associated with the binding protein, wherein the reporter group is adapted to undergo a luminescence change upon binding of the binding protein to the target analyte, and optionally, at least one reference group.
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Accused Products
Abstract
A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. An optical conduit, preferably an optical fiber has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.
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Citations
42 Claims
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1. A device for sensing a target analyte in a sample comprising:
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an optical conduit having a proximal end and a distal end;
an optical system at the proximal end of the optical conduit comprising at least one electromagnetic energy emitter and at least one electromagnetic energy detector; and
a sensing element in optical proximity to the distal end of the optical conduit comprising at least one binding protein adapted to bind with at least one target analyte and at least one reporter group associated with the binding protein, wherein the reporter group is adapted to undergo a luminescence change upon binding of the binding protein to the target analyte, and optionally, at least one reference group. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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Specification