System for filling and assembling pharmaceutical delivery devices
First Claim
1. An assembly for filling and capping a barrel of a pre-filled syringe, the assembly comprising:
- a) a syringe body having a neck end, a rimmed end, and a side wall extending between the neck end and rimmed end, the body having an outer surface and an inner surface;
b) a piston having an upper surface, a lower surface, and a side surface extending between the upper and lower surfaces, the inner surface of the body and the side surface of the piston in contact to form a liquid impermeable seal; and
c) a stabilization member that at least partially surrounds and contacts the outer surface of the body, the stabilization member is positioned proximate the rimmed end of the body to provide additional mass thereto in an amount sufficient to permit the assembly to be conveyed freestanding in a longitudinally upright position on the stabilization member through an apparatus for filling and capping pharmaceutical vials.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides for an assembly for filling and capping a barrel of a pre-filled syringe. The assembly includes a syringe body having a neck end, a rimmed end, and a side wall extending between the neck end and rimmed end. The body has an outer surface and an inner surface. The assembly includes a piston having an upper surface, a lower surface, and a side surface extending between the upper and lower surfaces. The inner surface of the body and the side surface of the piston is in contact to form a liquid impermeable seal. The assembly further includes a stabilization member that at least partially surrounds and contacts the outer surface of the body. The stabilization member is positioned proximate the rimmed end of the body to provide additional mass thereto in an amount sufficient to permit the assembly to be conveyed freestanding in a longitudinally upright position on the stabilization member through an apparatus for filling and capping pharmaceutical vials. Methods for producing a pre-filled syringe barrel are also provided.
56 Citations
39 Claims
-
1. An assembly for filling and capping a barrel of a pre-filled syringe, the assembly comprising:
-
a) a syringe body having a neck end, a rimmed end, and a side wall extending between the neck end and rimmed end, the body having an outer surface and an inner surface;
b) a piston having an upper surface, a lower surface, and a side surface extending between the upper and lower surfaces, the inner surface of the body and the side surface of the piston in contact to form a liquid impermeable seal; and
c) a stabilization member that at least partially surrounds and contacts the outer surface of the body, the stabilization member is positioned proximate the rimmed end of the body to provide additional mass thereto in an amount sufficient to permit the assembly to be conveyed freestanding in a longitudinally upright position on the stabilization member through an apparatus for filling and capping pharmaceutical vials. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
-
12. A method for producing a barrel for a pre-filled syringe, comprising:
-
a) providing a syringe body having a neck end, a rimmed end, and a side wall extending between the neck end and rimmed end, the body having an outer surface and an inner surface;
b) providing a piston having an upper surface, a lower surface, and a side surface extending between the upper and lower surfaces;
c) providing a stabilization member; and
d) forming an assembly comprising the syringe body, the piston, and the stabilization member such that;
(i) the inner surface of the body contacts at least a portion of the side surface of the piston to form a liquid impermeable seal;
(ii) the stabilization member at least partially surrounds and contacts the outer surface of the body; and
(iii) the stabilization member is positioned proximate the rimmed end of the body to provide additional mass thereto in an amount sufficient to permit the assembly to be conveyed freestanding in a longitudinally upright position on the stabilization member through an apparatus for filling and capping pharmaceutical vials. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
-
-
34. A method for producing a pre-filled syringe barrel, comprising:
-
a) providing a sterile assembly comprising a syringe body having a neck end, a rimmed end, a side wall extending between the neck end and the rimmed end, an outer surface and an inner surface, a piston having an upper surface, a lower surface, and a side surface extending between the upper and lower surfaces and a stabilization member, the sterile assembly formed such that;
(i) the inner surface of the body contacts at least a portion of the side surface of the piston to form a liquid impermeable seal;
(ii) the stabilization member is at least partially surrounds and contacts the outer surface of the body; and
(iii) the stabilization member is positioned proximate the rimmed end of the body to provide additional mass thereto in an amount sufficient to permit the assembly to be conveyed freestanding in a longitudinally upright position on the stabilization member through an apparatus for filling and capping pharmaceutical vials;
b) filling the body with at least one pharmaceutical component through the neck end using the apparatus for filling and capping pharmaceutical vials; and
c) capping the neck end of the body using the apparatus for filling and capping pharmaceutical vials. - View Dependent Claims (35, 36, 37, 38, 39)
-
Specification