Device, with electrospun fabric, for a percutaneous transluminal procedure, and methods thereof

• US 20050113868A1
• Filed: 06/22/2004
• Published: 05/26/2005
• Est. Priority Date: 11/20/2003
• Status: Abandoned Application

• Current Assignee: NMT Medical Incorporated
• Original Assignee: NMT Medical Incorporated
• Inventors: Devellian, Carol A., Widomski, David R.
• Application Number:
  US10/874,968
• Publication Number:
  US 20050113868A1
• Time in Patent Office: Days
• US Class Current: 606/213
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 17/12122 within the heart for closing a cardiac septal defect A61B17/0057
• CPC Class Codes: A61B 2017/00575 for closure at remote site, e.g. closing atrial septum defects
• CPC Class Codes: A61B 2017/00592 Elastic or resilient implements
• CPC Class Codes: A61B 2017/00606 Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening
• CPC Class Codes: A61B 2017/00831 Material properties

Abstract

The invention relates to an occluder for a percutaneous transluminal procedure. In one embodiment, the occluder includes an overall support structure and a plurality of occlusion shells connected to the overall support structure. At least one occlusion shell includes an electrospun fabric.

Claims

1. An occluder for a percutaneous transluminal procedure, comprising:

an overall support structure; and

a plurality of occlusion shells connected to the overall support structure, wherein at least one of the occlusion shells comprises an electrospun fabric.

2. The occluder of claim 1, wherein the electrospun fabric comprises an electrospun matrix of polymer fibers.

3. The occluder of claim 2, wherein the polymer fibers comprise a substance for stimulating tissue growth.

4. The occluder of claim 3, wherein the substance for stimulating tissue growth comprises collagen.

5. The occluder of claim 3, wherein the substance for stimulating tissue growth comprises a growth factor.

6. The occluder of claim 2, wherein the polymer fibers comprise an anti-thrombotic material.

7. The occluder of claim 6, wherein the anti-thrombotic material comprises heparin.

8. The occluder of claim 1, wherein the overall support structure comprises a metal.

9. The occluder of claim 1, wherein the overall support structure comprises a bioresorbable polymer.

10. The occluder of claim 9, wherein the bioresorbable polymer comprises polylactic acid.

11. The occluder of claim 1, wherein the overall support structure comprises a proximal support structure and a distal support structure.

12. The occluder of claim 11, wherein the proximal support structure and the distal support structure form a clip.

13. The occluder of claim 11, wherein the proximal support structure comprises a plurality of outwardly extending proximal arms and the distal support structure comprises a plurality of outwardly extending distal arms.

14. The occluder of claim 11, wherein the proximal support structure connects to a proximal occlusion shell and the distal support structure connects to a distal occlusion shell.

15. An occluder for a percutaneous transluminal procedure, comprising:

an overall support structure; and

at least one occlusion shell, connected to the overall support structure, comprising an electrospun fabric and a substance for stimulating tissue growth.

16. A method for percutaneous transluminal closure of a cardiac opening in a patient, comprising:

inserting an occluder into a heart of the patient, the occluder comprising;

an overall support structure; and

at least one occlusion shell connected to the overall support structure and comprising an electrospun fabric; and

positioning the occluder at least partially within the cardiac opening to substantially occlude the cardiac opening.

17. The method of claim 16, wherein the overall support structure of the occluder comprises a proximal support structure and a distal support structure, the proximal support structure connecting to a proximal occlusion shell and the distal support structure connecting to a distal occlusion shell, and wherein positioning the occluder at least partially within the cardiac opening comprises positioning a portion of the overall support structure within the cardiac opening and positioning the proximal occlusion shell and the distal occlusion shell on different sides of the cardiac opening.

18. The method of claim 16, wherein the cardiac opening is a patent foramen ovale.

19. The method of claim 16, wherein the cardiac opening is an atrial septal defect.

20. The method of claim 16, wherein the cardiac opening is a ventricular septal defect.

21. A method for percutaneous transluminal obliteration of a cardiac cul-de-sac in a patient, comprising:

inserting an occluder into a heart of the patient, the occluder comprising;

an overall support structure; and

at least one occlusion shell connected to the overall support structure and comprising an electrospun fabric; and

positioning the occluder at least partially within the cardiac cul-de-sac to substantially obliterate the cardiac cul-de-sac.

22. The method of claim 21, wherein the cardiac cul-de-sac is a left atrial appendage.

23. A method for making an occluder for a percutaneous transluminal procedure, comprising:

providing an overall support structure; and

connecting a plurality of occlusion shells to the overall support structure, wherein at least one of the plurality of occlusion shells comprises an electrospun fabric.

24. The method of claim 23, wherein the at least one occlusion shell comprising the electrospun fabric is connected to the overall support structure by electrospinning a matrix of polymer fibers directly onto the overall support structure.

25. The method of claim 23, wherein the at least one occlusion shell comprising the electrospun fabric is connected to the overall support structure by sewing at least one occlusion shell to the overall support structure, and by electrospinning a matrix of polymer fibers onto the at least one occlusion shell as a coating.

26. The method of claim 23, wherein the at least one occlusion shell comprising the electrospun fabric is connected to the overall support structure by laminating at least one occlusion shell to the overall support structure, and by electrospinning a matrix of polymer fibers onto the at least one occlusion shell as a coating.

27. The method of claim 23, wherein the at least one occlusion shell comprising the electrospun fabric is connected to the overall support structure by gluing at least one occlusion shell to the overall support structure, and by electrospinning a matrix of polymer fibers onto the at least one occlusion shell as a coating.

28. The method of claim 23 further comprising producing the electrospun fabric by electrospinning a matrix of a polymer fibers.

29. The method of claim 28, wherein electrospinning the matrix of polymer fibers comprises discharging a jet of polymer fibers.

30. The method of claim 29, wherein a direction of travel of the discharged jet of polymer fibers is controlled by applying an electric field across at least a portion of a length of the discharged jet.

31. The method of claim 29, wherein a direction of travel of the discharged jet of polymer fibers is controlled by applying a magnetic field across at least a portion of a length of the discharged jet.

32. The method of claim 29, wherein a direction of travel of the discharged jet of polymer fibers is controlled by applying an electromagnetic field across at least a portion of a length of the discharged jet.