Electrical stimulation system, lead, and method providing reduced neuroplasticity effects

• US 20050113882A1
• Filed: 11/18/2004
• Published: 05/26/2005
• Est. Priority Date: 11/20/2003
• Status: Abandoned Application

• Current Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories)
• Inventors: Chavez, Christopher G., Cameron, Tracy L.
• Application Number:
  US10/994,008
• Publication Number:
  US 20050113882A1
• Time in Patent Office: Days
• US Class Current: 607/45
• CPC Class Codes: A61N 1/0553 Paddle shaped electrodes, e.g. for laminotomy
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36103 Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke

Abstract

According to one aspect, an electrical stimulation system provides reduced neuroplasticity effects in a person'"'"'s nerve tissue. The system includes an electrical stimulation lead adapted for implantation into the person'"'"'s body for electrical stimulation of target nerve tissue. The lead includes a number of electrodes adapted to be positioned near the target nerve tissue and to deliver electrical stimulation energy to the target nerve tissue. The system also includes a stimulation source connectable to the lead and operable to generate signals for transmission to the electrodes of the lead to cause the electrodes to deliver electrical stimulation energy to the target nerve tissue to reduce neuroplasticity effects.

Claims

1. An electrical stimulation system providing reduced neuroplasticity effects in a person'"'"'s brain, comprising:

an electrical stimulation lead adapted for implantation into the person'"'"'s brain for electrical stimulation of target brain tissue, the lead comprising a plurality of electrodes adapted to be positioned near the target brain tissue and to deliver electrical stimulation energy to the target brain tissue;

a stimulation source connectable to the electrical stimulation lead and operable to generate signals for transmission to the electrodes of the electrical stimulation lead to cause the electrodes to deliver electrical stimulation energy to the target brain tissue to reduce neuroplasticity effects in the person'"'"'s brain.

2. The system of claim 1, wherein the neuroplasticity reducing electrical stimulation is randomized to make it more difficult for the brain to adapt to the neuroplasticity reducing electrical stimulation and dynamically reorganize itself accordingly.

3. The system of claim 1, wherein the stimulation source is operable to generate signals for transmission to the electrodes to cause the electrodes to deliver electrical stimulation energy to the target brain tissue to provide therapeutic electrical stimulation of the target brain tissue in addition to neuroplasticity reducing electrical stimulation, the neuroplasticity reducing electrical stimulation making it more difficult for the brain to dynamically reorganize itself to overcome effects of the therapeutic electrical stimulation.

4. The system of claim 3, wherein the target brain tissue is located in the person'"'"'s primary auditory cortex and the therapeutic electrical stimulation is provided to treat tinnitus.

5. The system of claim 3, wherein the stimulation source is operable to generate the signals for providing therapeutic electrical stimulation of the target brain tissue in association with the signals generated for reducing neuroplasticity effects, such that the electrodes are caused to deliver electrical energy for providing therapeutic electrical stimulation and electrical energy for reducing neuroplasticity effects substantially concurrently to the target brain tissue.

6. The system of claim 3, wherein the neuroplasticity reducing electrical stimulation is randomized about the therapeutic electrical stimulation.

7. The system of claim 3, wherein average intensity of the electrical stimulation energy delivered to reduce neuroplasticity effects is less than or equal to average intensity of the electrical stimulation energy delivered to provide therapeutic electrical stimulation.

8. The system of claim 1, wherein the stimulation source is operable to generate the signals according to one or more stimulation sets each specifying a plurality of stimulation parameters, the stimulation parameters for a stimulation set comprising a polarity for each electrode at each of one or more times within a stimulation pulse for the stimulation set.

9. The system of claim 8, wherein the polarity for at least one electrode changes for each of a sequence of times according to the stimulation parameters for the stimulation set.

10. The system of claim 8, wherein the polarity for an electrode at a time comprises either a relatively positive polarity, a relatively negative polarity, or an intermediate polarity between the relatively positive polarity and relatively negative polarity.

11. The system of claim 8, wherein the stimulation parameters for a stimulation set further comprise an amplitude, a frequency, phase information, and a pulse width for the stimulation pulse.

12. The system of claim 8, wherein at least one stimulation parameter for a stimulation set is randomized within a predetermined range during execution of the stimulation set.

13. The system of claim 8, wherein:

the stimulation source is operable to generate signals for transmission to the electrodes to cause the electrodes to deliver electrical stimulation energy to the target brain tissue to provide therapeutic electrical stimulation of the target brain tissue in addition to neuroplasticity reducing electrical stimulation, the neuroplasticity reducing electrical stimulation making it more difficult for the brain to dynamically reorganize itself to overcome effects of the therapeutic electrical stimulation; and

the stimulation source is operable to generate the signals according to one or more stimulation sets each specifying a plurality of stimulation parameters for a plurality of stimulation pulses, one or more of the stimulation pulses accomplishing therapeutic electrical stimulation of the target brain tissue and one or more other of the stimulation pulses accomplishing neuroplasticity reducing electrical stimulation of the target brain tissue.

14. The system of claim 13, wherein a therapeutic electrical stimulation pulse is separated from a successive therapeutic electrical stimulation pulse by a number of neuroplasticity reducing stimulation pulses greater than or equal to zero, the number being either predetermined or randomized.

15. The system of claim 8, wherein:

the stimulation source is operable to generate signals for transmission to the electrodes to cause the electrodes to deliver electrical stimulation energy to the target brain tissue to provide therapeutic electrical stimulation of the target brain tissue in addition to neuroplasticity reducing electrical stimulation, the neuroplasticity reducing electrical stimulation making it more difficult for the brain to dynamically reorganize itself to overcome effects of the therapeutic electrical stimulation; and

the stimulation source is operable to generate the signals according to a plurality of stimulation programs each comprising one or more stimulation sets, each stimulation set specifying a plurality of stimulation parameters, one or more of the stimulation sets accomplishing therapeutic electrical stimulation of the target brain tissue and one or more other of the stimulation sets accomplishing neuroplasticity reducing electrical stimulation of the target brain tissue.

16. The system of claim 15, wherein a therapeutic electrical stimulation set is separated from a successive therapeutic electrical stimulation set by a number of neuroplasticity reducing stimulation sets greater than or equal to zero, the number being either predetermined or randomized.

17. The system of claim 1, wherein the neuroplasticity effects are associated with therapeutic electrical stimulation of the person'"'"'s brain or are due to previous injury or disease.

18. The system of claim 1, wherein the target brain tissue comprises brain tissue located in a region of the person'"'"'s cortex.

19. The system of claim 18, wherein the target brain tissue comprises brain tissue associated with at least one of the person'"'"'s:

primary motor cortex;

primary somatosensory cortex;

primary visual cortex; and

primary auditory cortex.

20. The system of claim 1, wherein the target brain tissue comprises brain tissue located in a region of the person'"'"'s thalamus.

21. A method providing reduced neuroplasticity effects in a person'"'"'s brain, comprising:

using a stimulation source to generate signals for transmission to electrodes of an electrical stimulation lead implanted in the person'"'"'s brain to cause the electrodes to deliver electrical stimulation energy to target brain tissue to reduce neuroplasticity effects; and

in response to the signals transmitted from the stimulation source, using the electrodes of the electrical stimulation lead implanted in the person'"'"'s brain to deliver electrical stimulation energy to the target brain tissue to reduce neuroplasticity effects in the person'"'"'s brain.

22. The method of claim 21, wherein the neuroplasticity reducing electrical stimulation is randomized to make it more difficult for the brain to adapt to the neuroplasticity reducing electrical stimulation and dynamically reorganize itself accordingly.

23. The method of claim 21, further comprising using the stimulation source to generate signals for transmission to the electrodes to cause the electrodes to deliver electrical stimulation energy to the target brain tissue to provide therapeutic electrical stimulation of the target brain tissue in addition to neuroplasticity reducing electrical stimulation, the neuroplasticity reducing electrical stimulation making it more difficult for the brain to dynamically reorganize itself to overcome effects of the therapeutic electrical stimulation.

24. The method of claim 23, wherein the target brain tissue is located in the person'"'"'s primary auditory cortex and the therapeutic electrical stimulation is provided to treat tinnitus.

25. The method of claim 24, wherein the stimulation source generates the signals for providing therapeutic electrical stimulation of the target brain tissue in association with the signals generated for reducing neuroplasticity effects, such that the electrodes deliver electrical energy for providing therapeutic electrical stimulation and electrical energy for reducing neuroplasticity effects substantially concurrently to the target brain tissue.

26. The method of claim 24, wherein the neuroplasticity reducing electrical stimulation is randomized about the therapeutic electrical stimulation.

27. The method of claim 24, wherein average intensity of the electrical stimulation energy delivered to reduce neuroplasticity effects is less than or equal to average intensity of the electrical stimulation energy delivered to provide therapeutic electrical stimulation.

28. The method of claim 21, wherein the stimulation source generates the signals according to one or more stimulation sets each specifying a plurality of stimulation parameters, the stimulation parameters for a stimulation set comprising a polarity for each electrode at each of one or more times within a stimulation pulse for the stimulation set.

29. The method of claim 28, wherein the polarity for at least one electrode changes for each of a sequence of times according to the stimulation parameters for the stimulation set.

30. The method of claim 28, wherein the polarity for an electrode at a time comprises either a relatively positive polarity, a relatively negative polarity, or an intermediate polarity between the relatively positive polarity and relatively negative polarity.

31. The method of claim 28, wherein the stimulation parameters for a stimulation set further comprise an amplitude, a frequency, phase information, and a pulse width for the stimulation pulse.

32. The method of claim 28, wherein at least one stimulation parameter for a stimulation set is randomized within a predetermined range during execution of the stimulation set.

33. The method of claim 28, wherein:

the stimulation source generates signals for transmission to the electrodes to cause the electrodes to deliver electrical stimulation energy to the target brain tissue to provide therapeutic electrical stimulation of the target brain tissue in addition to neuroplasticity reducing electrical stimulation, the neuroplasticity reducing electrical stimulation making it more difficult for the brain to dynamically reorganize itself to overcome effects of the therapeutic electrical stimulation; and

the stimulation source generates the signals according to one or more stimulation sets each specifying a plurality of stimulation parameters for a plurality of stimulation pulses, one or more of the stimulation pulses accomplishing therapeutic electrical stimulation of the target brain tissue and one or more other of the stimulation pulses accomplishing neuroplasticity reducing electrical stimulation of the target brain tissue.

34. The method of claim 33, wherein a therapeutic electrical stimulation pulse is separated from a successive therapeutic electrical stimulation pulse by a number of neuroplasticity reducing stimulation pulses greater than or equal to zero, the number being either predetermined or randomized.

35. The system of claim 28, wherein:

the stimulation source generates signals for transmission to the electrodes to cause the electrodes to deliver electrical stimulation energy to the target brain tissue to provide therapeutic electrical stimulation of the target brain tissue in addition to neuroplasticity reducing electrical stimulation, the neuroplasticity reducing electrical stimulation making it more difficult for the brain to dynamically reorganize itself to overcome effects of the therapeutic electrical stimulation; and

the stimulation source generates the signals according to a plurality of stimulation programs each comprising one or more stimulation sets, each stimulation set specifying a plurality of stimulation parameters, one or more of the stimulation sets accomplishing therapeutic electrical stimulation of the target brain tissue and one or more other of the stimulation sets accomplishing neuroplasticity reducing electrical stimulation of the target brain tissue.

36. The method of claim 35, wherein a therapeutic electrical stimulation set is separated from a successive therapeutic electrical stimulation set by a number of neuroplasticity reducing stimulation sets greater than or equal to zero, the number being either predetermined or randomized.

37. The method of claim 21, wherein the neuroplasticity effects are associated with therapeutic electrical stimulation of the person'"'"'s brain or are due to previous injury or disease.

38. The method of claim 21, wherein the target brain tissue comprises brain tissue located in a region of the person'"'"'s cortex.

39. The method of claim 38, wherein the target brain tissue comprises brain tissue associated with at least one of the person'"'"'s:

primary motor cortex;

primary somatosensory cortex;

primary visual cortex; and

primary auditory cortex.

40. The method of claim 21, wherein the target brain tissue comprises brain tissue located in a region of the person'"'"'s thalamus.

41. An electrical stimulation system providing electrical stimulation of a person'"'"'s brain to reduce neuroplasticity effects associated with concurrent therapeutic electrical stimulation of the person'"'"'s brain, comprising:

an electrical stimulation lead adapted for implantation into the person'"'"'s brain for electrical stimulation of target brain tissue, the lead comprising a plurality of electrodes adapted to be positioned near the target brain tissue and to deliver electrical stimulation energy to the target brain tissue in response to received signals; and

a stimulation source adapted for implantation into the person'"'"'s body and operable to concurrently;

generate signals for transmission to the electrodes of the lead to cause the electrodes to deliver electrical stimulation energy to the target brain tissue within the stimulation pulse to provide therapeutic electrical stimulation of the target brain tissue; and

generate signals for transmission to the electrodes of the lead to cause the electrodes to deliver electrical stimulation energy to the target brain tissue within the stimulation pulse to reduce neuroplasticity effects associated with the therapeutic electrical stimulation of the target brain tissue, the neuroplasticity reducing electrical stimulation being randomized about the therapeutic electrical stimulation, the neuroplasticity reducing electrical stimulation making it more difficult for the brain to dynamically reorganize itself to overcome effects of the therapeutic electrical stimulation;

the signals generated according to a plurality of stimulation programs each comprising one or more stimulation sets, each stimulation set specifying a plurality of stimulation parameters comprising a polarity for each electrode of the lead at each of one or more times, the polarities for the electrodes changing over time according to the stimulation parameters, one or more stimulation sets accomplishing therapeutic electrical stimulation of the target brain tissue and one or more other stimulation sets accomplishing neuroplasticity reducing electrical stimulation of the target brain tissue, each therapeutic electrical stimulation set being separated from a next therapeutic electrical stimulation set by a number of neuroplasticity reducing stimulation sets that is greater than or equal to zero.

42. An electrical stimulation system providing reduced neuroplasticity effects in a person'"'"'s nerve tissue, comprising:

an electrical stimulation lead adapted for implantation into the person'"'"'s body for electrical stimulation of target nerve tissue, the lead comprising a plurality of electrodes adapted to be positioned near the target nerve tissue and deliver electrical stimulation energy to the target nerve tissue;

a stimulation source connectable to the electrical stimulation lead and operable to generate signals for transmission to the electrodes of the electrical stimulation lead to cause the electrodes to deliver electrical stimulation energy to the target nerve tissue to reduce neuroplasticity effects in the target nerve tissue.

43. The system of claim 42, wherein the target nerve tissue comprises one of brain tissue, spinal cord tissue, and peripheral nerve tissue.

44. An electrical stimulation system for stimulating a person'"'"'s brain, comprising:

an electrical stimulation lead adapted for implantation into the person'"'"'s brain for electrical stimulation of target brain tissue, the lead comprising a plurality of electrodes adapted to be positioned near the target brain tissue and to deliver electrical stimulation energy to the target brain tissue;

two or more stimulation sets each specifying stimulation parameters; and

a stimulation source connectable to the electrical stimulation lead and operable to generate signals according to the two or more stimulation sets for transmission to the electrodes of the electrical stimulation lead to cause the electrodes to deliver electrical stimulation energy to the target brain tissue.

45. The system of claim 44, wherein the stimulation occurs according to a first stimulation set in one or more first stimulation periods and according to a second stimulation set in one or more second time periods distinct from the one or more first time periods.