Method and device for the removal of partially protein bound substances
First Claim
1. A method for removing partially carrier bound substances from blood comprising a blood circuit, a fluid circuit and a filter having a semipermeable membrane separating a fluid compartment from a blood compartment, where blood is directed through the blood compartment and a cleaning fluid is directed through the fluid compartment characterized in that a mass transfer coefficient koA of the filter is at least 2000 ml/min;
- a ratio between the mass transfer coefficient koA of the filter and a blood flow rate is at least 5;
a cleaning fluid flow rate is at least 2000 ml/min; and
a ratio between the cleaning fluid flow rate and the blood flow rate is at least 5.
3 Assignments
0 Petitions
Accused Products
Abstract
A method and a device to increase the efficiency of dialysis for the removal from blood of substances that are more or less tightly bound to carriers such as albumin. According to the invention this is accomplished by a simultaneous significant increase of the flow rate of the dialysis fluid and of the area of the membrane that separates the blood from the dialysis fluid, compared to conventional dialysis.
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Citations
30 Claims
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1. A method for removing partially carrier bound substances from blood comprising a blood circuit, a fluid circuit and a filter having a semipermeable membrane separating a fluid compartment from a blood compartment, where blood is directed through the blood compartment and a cleaning fluid is directed through the fluid compartment characterized in that
a mass transfer coefficient koA of the filter is at least 2000 ml/min; -
a ratio between the mass transfer coefficient koA of the filter and a blood flow rate is at least 5;
a cleaning fluid flow rate is at least 2000 ml/min; and
a ratio between the cleaning fluid flow rate and the blood flow rate is at least 5. - View Dependent Claims (2, 3, 4, 5, 13, 14, 15)
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6. A method for removing partially carrier bound substances from blood comprising a blood circuit, a fluid circuit and a filter having a semipermeable membrane separating a fluid compartment from a blood compartment, where blood is directed through the blood compartment and a cleaning fluid is directed through the fluid compartment characterized in that
a mass transfer coefficient koA of the filter is at least 2000 ml/min; -
a ratio between the mass transfer coefficient koA of the filter and a blood flow rate is at least 5; and
the cleaning fluid contains a carrier that is able to bind the partially carrier bound substances in the blood. - View Dependent Claims (8, 10, 11)
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7. A method for removing partially carrier bound substances from blood comprising a blood circuit, a fluid circuit and a filter having a semipermeable membrane separating a fluid compartment from a blood compartment, where blood is directed through the blood compartment and a cleaning fluid is directed through the fluid compartment characterized in that
the membrane has been pretreated with a fluid containing a carrier that is able to bind the partially carrier bound substances in the blood; -
a cleaning fluid flow rate is at least 2000 ml/min; and
a ratio between the cleaning fluid flow rate and the blood flow rate is at least 10. - View Dependent Claims (9)
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12. A method for removing partially carrier bound substances from blood comprising a blood circuit, a fluid circuit and a filter having a semipermeable membrane separating a fluid compartment from a blood compartment, where a mixture of blood and a cleaning fluid is directed through the blood compartment and a pressure gradient is applied across the membrane to create an ultrafiltration into the fluid compartment equal in size to the sum of a flow rate of the cleaning fluid and a desired weight loss rate of a patient characterized in that
a water permeability coefficient LpA of the filter is at least 10 ml/min/mm Hg; -
the cleaning fluid flow rate is at least 1000 ml/min; and
a ratio between the cleaning fluid flow rate and a blood flow rate is at least 5.
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16. A device adapted to remove partially carrier bound substances from blood comprising a blood circuit, a fluid circuit and a filter having a semipermeable membrane separating a fluid compartment from a blood compartment, where blood is directed through the blood compartment and a cleaning fluid is directed through the fluid compartment characterized in that
a mass transfer coefficient koA of the filter is at least 2000 ml/min; -
a ratio between the mass transfer coefficient koA of the filter and a blood flow rate is at least 5;
a cleaning fluid flow rate is at least 2000 ml/min; and
a ratio between the cleaning fluid flow rate and the blood flow rate is at least 5. - View Dependent Claims (17, 18, 19, 20, 28, 29, 30)
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21. A device adapted to remove partially carrier bound substances from blood comprising a blood circuit, a fluid circuit and a filter having a semipermeable membrane separating a fluid compartment from a blood compartment, where blood is directed through the blood compartment and a cleaning fluid is directed through the fluid compartment characterized in that
a mass transfer coefficient koA of the filter is at least 2000 ml/min; -
a ratio between the mass transfer coefficient koA of the filter and a blood flow rate is at least 5; and
the cleaning fluid contains a carrier that is able to bind the partially carrier bound substances in the blood. - View Dependent Claims (23, 25, 26)
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22. A device adapted to remove partially carrier bound substances from blood comprising a blood circuit, a fluid circuit and a filter having a semipermeable membrane separating a fluid compartment from a blood compartment, where blood is directed through the blood compartment and a cleaning fluid is directed through the fluid compartment characterized in that
the membrane has been pretreated with a fluid containing a carrier that is able to bind the partially carrier bound substances in the blood; -
a cleaning fluid flow rate is at least 2000 ml/min; and
a ratio between the cleaning fluid flow rate and the blood flow rate is at least 10. - View Dependent Claims (24)
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27. A device adapted to remove partially carrier bound substances from blood comprising a blood circuit, a fluid circuit and a filter having a semipermeable membrane separating a fluid compartment from a blood compartment, provided with means for mixing blood and a cleaning fluid and directing said mixture through the blood compartment, and means to apply a pressure gradient across the membrane to create an ultrafiltration into the fluid compartment equal in size to the sum of a flow rate of the cleaning fluid and a desired weight loss rate of the patient characterized in that
a water permeability coefficient LpA of the filter is at least 10 ml/min/mm Hg; -
the cleaning fluid flow rate is at least 1000 ml/min; and
a ratio between the cleaning fluid flow rate and a blood flow rate is at least 5.
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Specification