Antimicrobial lenses, processes to prepare them and methods of their use

• US 20050117112A1
• Filed: 06/30/2004
• Published: 06/02/2005
• Est. Priority Date: 11/18/2003
• Status: Active Grant

• Current Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Inventors: Meyers, Ann-Marie Wong, Susan, Brown-Skrobot, Nayiby, Alvarez-Carrigan, Frank, Neely, Brian, Pall, Osman, Rathore
• Granted Patent: US 7,416,737 B2
• Time in Patent Office: Days
• US Class Current: 351/160.R
• CPC Class Codes: A61L 12/08 using chemical substances
• CPC Class Codes: A61L 12/088 Heavy metals
• CPC Class Codes: A61L 12/105 Iodine, iodides or iodophores
• CPC Class Codes: A61P 27/02 Ophthalmic agents

Abstract

This invention relates to solutions for packaging ophthalmic devices comprising at least one antimicrobial metal salt which prevent the loss of said antimicrobial metal salt during autoclaving and storage.

Claims

1. A packaging solution for packaging an ophthalmic device comprising at least one antimicrobial metal salt having a K_sp of less than about 10⁻

10 wherein said solution is substantially free from packaging solution salts which have anions which when combined with said antimicrobial metal form a salt having a K_sp of more than about 10<sup>−

6</sup>.

2. The packaging solution of claim 1 wherein the K_sp of the salt formed from said antimicrobial metal and packaging solution salt anion is more than about 10⁻

6.

3. The packaging solution of claim 1 wherein said packaging solution has an osmolality of about 220 mOsm/kg or greater.

4. The packaging solution of claim 1 wherein said packaging solution salts has an osmolality of about 230 mOsm/kg or greater.

5. The packaging solution of claim 1 wherein said packaging solution has a conductivity of at least about 4 mS/cm or greater.

6. The packaging solution of claim 1 wherein said packaging solution has a conductivity of at least about 5 mS/cm or greater

7. The packaging solution of claim 1 wherein said ophthalmic device is a contact lens.

8. The packaging solution of claim 1 wherein said antimicrobial metal salt comprises at least one cation selected from the group consisting of Al⁺³, Co⁺², Co⁺³, Ca⁺², Mg⁺², Ni⁺², Ti⁺², Ti⁺³, Ti⁺⁴, V⁺², V⁺³, V⁺⁵, Sr⁺², Fe⁺², Fe⁺³, Ag⁺², Ag⁺, Au⁺², Au⁺³, Au⁺¹, Pd⁺², Pd⁺⁴, Pt⁺², Pt⁺⁴, Cu⁺¹, Cu⁺², Mn⁺², Mn⁺³, Mn⁺⁴, Zn⁺² and combinations thereof.

9. The packaging solution of claim 1 wherein said antimicrobial metal salt comprises at least one cation selected from the group consisting of Mg⁺², Zn⁺², Cu⁺¹, Cu⁺², Au⁺², Au⁺³, Au⁺¹, Pd⁺², Pd⁺⁴, Pt⁺², Pt⁺⁴, Ag⁺², Ag⁺¹ and combinations thereof.

10. The packaging solution of claim 1 wherein said antimicrobial metal is a silver salt.

11. The packaging solution of claim 1 wherein said antimicrobial metal salt is selected from the group consisting of manganese sulfide, zinc oxide, zinc sulfide, copper sulfide, copper phosphate, silver nitrate, silver sulfate, silver iodate, silver carbonate, silver phosphate, silver sulfide, silver chloride, silver bromide, silver iodide, silver oxide and mixtures thereof.

12. The packaging solution of claim 1 wherein said antimicrobial metal salt is selected from the group consisting of silver iodide, silver chloride, silver bromide and mixtures thereof.

13. The packaging solution of claim 1 wherein said ophthalmic device loses less than about 30% by weight of the antimicrobial salt during autoclaving and storing.

14. The packaging solution of claim 1 wherein said ophthalmic device loses less than about 20% by weight of the antimicrobial salt during autoclaving and storing.

15. The packaging solution of claim 1 wherein said ophthalmic device loses less than about 15% by weight of the antimicrobial salt after at least two autoclaving cycles.

16. The packaging solution of claim 1 wherein said solution is a borate buffered solution comprising at least one salt selected from the group consisting of sodium sulfate, sodium lactate, sodium citrate, sodium chloride and mixtures thereof.

17. A packaging solution for packaging an ophthalmic device comprising at least one antimicrobial metal salt having a K_sp wherein said solution is substantially free from packaging solution salts which have anions which when combined with said antimicrobial metal form a salt having a K_sp which is at least about six orders of magnitude different that said Ksp of said antimicrobial metal salt.

18. A packaging solution for packaging an ophthalmic device comprising at least one antimicrobial metal salt having a K_sp wherein said solution is substantially free from packaging solution salts which have anions which when combined with said antimicrobial metal form a salt having a K_sp which is more than about six orders of magnitude different that said K_sp of said antimicrobial metal salt and said antimicrobial metal salt is present in a concentration sufficient to provide loss upon autoclaving of less than about 15%.

19. A method for reducing loss of an antimicrobial metal from an ophthalmic lens packaged in a packaging solution comprising the step of packaging said ophthalmic lens in a packaging solution which is substantially free from packaging solution salts which have anions which when combined with said antimicrobial metal form a salt having a K_sp of less than about 10⁻

6.