Ionic silver complex

• US 20050118281A1
• Filed: 01/04/2005
• Published: 06/02/2005
• Est. Priority Date: 11/09/1998
• Status: Abandoned Application

• Current Assignee: David Washburn, Ira Jay Newman
• Original Assignee: David Washburn, Ira Jay Newman
• Inventors: Newman, Ira Jay, Washburn, David
• Application Number:
  US11/028,840
• Publication Number:
  US 20050118281A1
• Time in Patent Office: Days
• US Class Current: 424/618
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/18 Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0034 Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61K 9/0095 Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/16 for influenza or rhinoviruses
• CPC Class Codes: Y10S 424/06 Chelate
• CPC Class Codes: Y10S 424/13 : Burn treatment

Abstract

The invention relates to a substantially non-colloidal solution comprising (a) water; (b) silver ions; and (c) a substantially non-toxic, substantially thiol-free, substantially water-soluble complexing agent.

Claims

1. A substantially non-colloidal solution made by combining ingredients comprising:

(a) water;

(b) a source of free silver ions; and

(c) a substantially non-toxic, substantially thiol-free, substantially water-soluble complexing agent.

2. The substantially non-colloidal solution of claim 1, wherein the non-colloidal solution possesses less than about ten weight percent of free silver based on the weight of total silver.

3. The substantially non-colloidal solution of claim 2, wherein the non-colloidal solution possesses less than about one weight percent of free silver based the weight of total silver.

4. The substantially non-colloidal solution of claim 3, wherein the non-colloidal solution possesses less than about one-tenth of a percent by weight of free silver based on the weight of total silver.

5. The substantially non-colloidal solution of claim 1, wherein the non-colloidal solution possesses greater than about twenty parts of total silver per million parts of the non-colloidal solution.

6. The substantially non-colloidal solution of claim 5, wherein the non-colloidal solution possesses greater than about fifty parts of total silver per million parts of the non-colloidal solution.

7. The substantially non-colloidal solution of claim 6, wherein the non-colloidal solution possesses greater than or equal to about one hundred parts of total silver per million parts of the non-colloidal solution.

8. The substantially non-colloidal solution of claim 1, wherein the source of free silver ions comprises silver oxide, trisilver citrate, or silver acetate.

9. The substantially non-colloidal solution of claim 8, wherein the source of free silver ions comprises silver oxide.

10. The substantially non-colloidal solution of claim 1, wherein the substantially non-toxic, substantially thiol-free, substantially water-soluble complexing agent comprises a carboxylic acid, or a primary, secondary or tertiary amine.

11. The substantially non-colloidal solution of claim 10, wherein the substantially non-toxic, substantially thiol-free, substantially water-soluble complexing agent comprises amino acids or hydroxy acids.

12. The substantially non-colloidal solution of claim 11, wherein the amino acids comprise glycine, alanine, valine, leucine, isoleucine, methionine, proline, phenylalanine, tryptophan, serine, threonine, tyrosine, asparagine, glutamine, aspartic acid, glutamic acid, lysine, arginine, or histidine.

13. The substantially non-colloidal solution of claim 12, wherein the hydroxy acids comprise glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, or mandelic acid.

14. The substantially non-colloidal solution of claim 13;

wherein the citric acid is dibasic citrate.

15. The substantially non-colloidal solution of claim 1, wherein the free silver ions are present in the substantially non-colloidal solution in an anti-microbially effective amount.

16. The substantially non-colloidal solution of claim 1, wherein the ingredients further comprise a source of counter-ions.

17. The substantially non-colloidal solution of claim 1, wherein the source of counter-ions comprises potassium ions, or calcium ions.