Thioaptamers enable discovery of physiological pathways and new therapeutic strategies
First Claim
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1. A method of disrupting selectively a target molecule within a physiological pathway comprising the steps of:
- characterizing a detectable activity of the physiological pathway;
identifying a thioaptamer that modifies the activity of the target molecule of the physiological pathway; and
determining the extent of the modification to the activity of the physiological pathway in the presence of the thioaptamer.
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Abstract
A system and method for determining the effect of a target molecule within a physiological pathway is disclosed in which a thioaptamer is used to affect a detectable activity of the physiological pathway in a cell or cell fragment.
63 Citations
47 Claims
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1. A method of disrupting selectively a target molecule within a physiological pathway comprising the steps of:
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characterizing a detectable activity of the physiological pathway;
identifying a thioaptamer that modifies the activity of the target molecule of the physiological pathway; and
determining the extent of the modification to the activity of the physiological pathway in the presence of the thioaptamer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of testing a chemical agent comprising the steps of:
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exposing a cell having a measurable biochemical activity to a thioaptamer that modifies the activity of a target molecule;
contacting at least a portion of the cell with the chemical agent; and
measuring the effect that the chemical agent has on the measurable biochemical activity. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A system for testing the biological effects of a molecule comprising:
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at least a portion of a cell comprising a target molecule and a measurable biochemical activity;
a thioaptamer that modifies the activity of the target molecule that is added to the cell; and
a biochemical activity detection device that records differences in the measurable biochemical activity of the cell upon exposure to the molecule. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47)
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Specification