Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof

• US 20050119182A1
• Filed: 11/02/2004
• Published: 06/02/2005
• Est. Priority Date: 04/14/1997
• Status: Active Grant

• Current Assignee: Arena Pharmaceuticals Incorporated
• Original Assignee: Arena Pharmaceuticals Incorporated
• Inventors: Liaw, Chen W., Chalmers, Derek T., Thomsen, William J., Behan, Dominic P., Russo, Joseph F.
• Granted Patent: US 7,368,539 B2
• Time in Patent Office: Days
• US Class Current: 530/350
• CPC Class Codes: C07D 231/12 with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 231/16 Halogen atoms or nitro radicals
• CPC Class Codes: C07D 409/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07K 14/70571 for neuromediators, e.g. serotonin receptor, dopamine receptor
• CPC Class Codes: C07K 14/723 G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
• CPC Class Codes: G01N 2333/70571 for neuromediators, e.g. serotonin receptor, dopamine receptor
• CPC Class Codes: G01N 2333/726 G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
• CPC Class Codes: G01N 33/566 using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds

Abstract

Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT2A and human 5-HT_2C receptors and uses of such receptors to screen candidate compounds. Further disclosed herein are candidate compounds identified by the screening method which act at the 5HT2A receptors. Yet further disclosed is a new class of compounds which act at the 5HT2A receptors.

Claims

1. An isolated nucleic acid comprising SEQ ID NO:

24.

2. An isolated polypeptide comprising the amino acid sequence encoded by SEQ ID NO:

24.