Method and apparatus for determining cerebral oxygen saturation

• US 20050119542A1
• Filed: 02/27/2003
• Published: 06/02/2005
• Est. Priority Date: 02/27/2002
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Neurophysics Corporation
• Inventors: Olden, Timothy, Martin, Dale, Stoddart, Hugh A., Stoddart, Hugh F., Sefranek, Thomas Christopher John
• Granted Patent: US 7,221,969 B2
• Time in Patent Office: Days
• US Class Current: 600/323
• CPC Class Codes: A61B 2562/0242 for varying or adjusting the optical path length in the tissue
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: A61B 5/1464 specially adapted for foetal tissue
• CPC Class Codes: G01N 2021/3144 for oxymetry
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B
• CPC Class Codes: G01N 21/49 within a body or fluid

Abstract

A new and improved method and apparatus for determining cerebral oxygenation. In one basic aspect, a new processing methodology for oxygenation determination, in particular cerebral oxygenation, is provided based on the apprehension and discovery that time-based photon quantity determinations of the wavelength-specific light leaving the head of the patient may be significantly improved, and simplified, by determining the quantity of returning photons in at least one set of two different but closely spaced points in time following the instant of injection, and then taking the ratio of the determinations in each set, to thereby cancel and remove several important sources of error.

Claims

1. Apparatus for spectrophotometrically monitoring hemoglobin oxygenation in a test subject, comprising in combination:

a source of photons having a desired wavelength;

a probe coupled to said source to optically access a single location on the test subject by injecting photons into said subject from said source at said location and for receiving photons exiting said subject at said location after injection;

a photon-conducting device operatively associated with said probe to receive a stream of said exiting photons and to produce at least two differently timed streams of photons therefrom;

a shuttered device coupled to said photon-conducting device to receive said at least two differently-timed photon streams and simultaneously switch each of said two streams on and off to create a pair of different photon bursts therefrom; and

a detector coupled to said shutter device to receive said pair of separate photon bursts and provide corresponding output signals for processing.

2. The apparatus for monitoring hemoglobin oxygenation in a test subject according to claim 1, wherein said photon-conducting device operatively associated with said probe comprises at least two fiberoptics having different effective light-conducting lengths to create said at least two differently-timed photon streams.

3. The apparatus for monitoring hemoglobin oxygenation in a test subject according to claim 1, wherein said shutter device comprises an image intensifier.

4. The apparatus for monitoring hemoglobin oxygenation in a test subject according to claim 3, wherein said photon-conducting device operatively coupled to said probe comprises at least two fiberoptics having different effective light-conducting lengths to create said at least two differently-timed photon streams.

5. The apparatus for monitoring hemoglobin oxygenation in a test subject according to claim 4, wherein each of said at least two fiberoptics is coupled to said image intensifier to provide inputs which are switched simultaneously thereby.

6. The apparatus for monitoring hemoglobin oxygenation in a test subject according to claim 5, wherein said image intensifier includes a generally annular photocathode and each of said at least two fiberoptics is terminated at said photocathode in a position spaced from the other, whereby said image intensifier produces at least two outputs and each such output is separately representative of a different one of said inputs.

7. The apparatus for monitoring hemoglobin oxygenation in a test subject according to claim 6, wherein said image intensifier has an output element, and including at least two output conductors coupled to said output element to receive separate output signals therefrom, each of said separate output signals representative of a different one of said inputs.

8. The apparatus for monitoring hemoglobin oxygenation in a test subject according to claim 7, wherein each of said at least two output conductors is coupled to said image intensifier output element in direct alignment with a different one of said at least two image intensifier inputs.

9. The apparatus for monitoring hemoglobin oxygenation in a test subject according to claim 1, including a fiberoptic conductor coupled between said source of photons and said probe for providing said photons for injection into said subject, wherein said fiberoptic conductor comprises a partially absorbing fiberoptic to discriminate against photon stream reverberation due to scatter and reflection efforts.

10. The apparatus for monitoring hemoglobin oxygenation in a test subject according to claim 3, including a coupling between a gating electrode of said image-intensifier and said photon source, whereby said image intensifier is gated on and off by operation of said source, said coupling including a device to convert from said source into a corresponding electrical signal.

11. The apparatus for monitoring hemoglobin oxygenation in a test subject according to claim 10, wherein said coupling includes an avalanche transistor array.

12. A method of processing optically produced hemoglobin oxygenation data which includes at least two signals that are respectively representative of at least two quantities of examination light which are emitted from a test subject at different points in time with respect to each other following the input of related and corresponding examination light has been pulse into said test subject, said method comprising the step of computing a value for each of said at least two signals and taking the ratio of said at least two signal values to thereby cancel out and thus remove error sources common to each of said at least two values.

13. The method of claim 12, wherein said computational method includes use of the equation

N∝

TS e<sup>−

ρ

σ

(λ

,f)ct</sup>

where;

N=number of photons (or equivalent, e.g., value)

T=transmission at the fiberoptic-skin interface

S=sensitivity of the shuttered-detector

ρ

=density of hemoglobin molecules (a) to blood density

σ

=cross-section of a hemoglobin molecule at wavelength λ and

fractional oxygen f

c=velocity of photons in tissue, and

t=time delay from injection.

14. The method of claim 13, wherein the value “

S”

in said computational method is made identical in the computation for each of said at least two signal values by using a common shuttered-detector for determining each of said at least two signal values, whereby said value “

S”

will cancel out when said ratio of signal values is taken.

15. The method of claim 13, wherein the value “

T”

in said computational method is made to be substantially identical in the computation for each of said at least two signal values by inputting said examination light corresponding to said at least two streams of emitted examination light at substantially the same point in time.

17. The method of claim 12, including the step of using a fast shuttered detector to determine said at least two quantities of examination light.

18. The method of claim 17, wherein said step of using a fast shuttered detector comprises using a single such detector to determine each of said at least two quantities of light.

19. The method of claim 17, wherein said step of using a fast shuttered detector is carried out by using an image-intensifier.

25. The method of claim 19, wherein said corresponding concurrent signals are assigned corresponding valuations and said evaluative processing includes taking a ratio of said corresponding signal valuations.

16. (canceled)

20. A method of monitoring hemoglobin oxygenation in a test subject, comprising the steps of:

injecting a quantity of photons having a predetermined wavelength into said test subject at a predetermined time and location;

optically accessing said predetermined location on said test subject to receive photons exiting said test subject at at least two different timed intervals following said time of injecting; and

converting said received photons exiting said test subject at at least two different timed intervals into at least two corresponding concurrent signals for subsequent evaluative processing

said step of converting said photons exiting said test subject at different times into corresponding concurrent signals being carried out substantially simultaneously.

21. The method of claim 20, wherein said step of converting said photons exiting said test subject at different times into corresponding concurrent signals is carried on simultaneously.

22. The method of claim 21, wherein said step of converting is carried out at least in part by applying said photons to a common switching device as separate photon groupings.

23. The method of claim 20, wherein said step of converting said photons into corresponding concurrent signals includes the step of delaying a photon grouping received at a longer time interval after injection into said test subject at a first time with respect to a different grouping injected at a second and subsequent time.

24. The method of claim 20, wherein said step of converting is carried out at least in part by applying said photons to a common switching device as separate photon groupings.