Microdialysis probe with inserting means and assembly

• US 20050119588A1
• Filed: 12/27/2002
• Published: 06/02/2005
• Est. Priority Date: 12/28/2001
• Status: Abandoned Application

• Current Assignee: Microbiotech/Se AB
• Original Assignee: Microbiotech/Se AB
• Inventors: Karlsson, Hans, Model, Per
• Application Number:
  US10/498,917
• Publication Number:
  US 20050119588A1
• Time in Patent Office: Days
• US Class Current: 600/581
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61M 1/1678 intracorporal peritoneal dialysis A61M1/28

Abstract

A microdialysis probe comprises a tubiform probe body, a tubiform dialysis membrane disposed distally of the probe body, and flexible conduits for adducing and abducing dialysis fluid, distal end portions of which are disposed in the probe body. Apart from the conduit portions disposed externally of the probe body the probe is substantially rotationally symmetrical. One of the conduits, preferably the abducing conduit, comprises an S-shaped portion inside of the probe, adjacent to the distal end of the other conduit. Also disclosed is an assembly of the probe and a cannula for inserting it into tissue; after insertion the cannula can be withdrawn in a proximal direction.

Claims

1. A microdialysis probe comprising a tubiform probe body, a tubiform dialysis membrane disposed distally of the probe body, and flexible conduits for adducing and abducing dialysis fluid, distal end portions of which are disposed in the probe body, the probe being, apart from the conduit portions disposed externally of the probe body, substantially rotationally symmetrical, one of said conduits comprising an S-shaped portion inside of the probe adjacent to the distal end of the other conduit.

2. The probe of claim 1, wherein the conduit comprising the S-shaped portion is the abducing conduit and has a distal end portion extending distally of the probe body.

3. The probe of claim 1, wherein the sum of the outer diameters of the conduits corresponds to the inner diameter of the probe body.

4. The probe of claim 1 having a maximum outer diameter of 1.5 mm or less.

5. The probe of claim 1, comprising a rear fitting connected to the probe body at the proximal end thereof so as to make a proximal end portion of the probe body to be enclosed by the rear fitting thereby forming a first chamber communicating via the probe body lumen with a second chamber formed by the membrane which is connected to the probe body at a distal end portion thereof.

6. The probe of claim 1, wherein a probe body distal end portion is enclosed by a proximal end portion of the membrane.

7. The probe of claim 1, wherein the membrane is plugged end or closed in any other convenient manner at its front end.

8. The probe of a of claim 1, wherein the adducing and abducing flexible conduits are sealingly fastened at the rear fitting, in particular at a proximal end portion thereof, so as to make one of them extend through the rear fitting and the probe body and having its front end located in the front chamber adjacent to the distal end of the membrane, and to make the other of them having its front end disposed in the rear chamber.

9. The probe of claim 8, wherein the adducing and abducing tubes are sealingly fastened to the rear fitting at a proximal portion thereof.

10. The probe of claim 1, wherein the probe body is radiologically opaque.

11. The probe of claim 10, wherein the probe body comprises a polymer or a mixture of polymers and radiologically opaque material finely dispersed therein.

12. The probe of claim 11, wherein said radiologically opaque materials comprises barium sulphate.

13. The combination of the microdialysis probe of claim 1 and a cannula the lumen of which is larger than the maximum outer diameter of the probe.

14. The combination of claim 13, wherein the microdialysis probe is designed to be received in the cannula in its entirety except for proximal end portions of the adducing and abducing flexible tubes, and in combination with which it can be inserted into living tissue and from which it is slidingly removable in a proximal direction.

15. The combination of claim 12, wherein the cannula comprises a holding means disposed near its proximal end.

16. The combination of claim 12 in a configuration ready for insertion packaged in a sterile condition.

17. The combination of claim 13, wherein the cannula comprises a holding means disposed near its proximal end.

18. The combination of claim 13 in a configuration ready for insertion packaged in a sterile condition.

19. The combination of claim 14 in a configuration ready for insertion packaged in a sterile condition.

20. The probe of claim 4 having a maximum outer diameter from 0.8 to 1.2 mm.