Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease

• US 20050119703A1
• Filed: 01/06/2004
• Published: 06/02/2005
• Est. Priority Date: 08/05/1998
• Status: Active Grant

• Current Assignee: Cyberonics, Inc, DiLorenzo Biomedical, LLC
• Original Assignee: NeuroVista Corporation
• Inventors: DiLorenzo, Daniel John
• Granted Patent: US 7,242,984 B2
• Time in Patent Office: Days
• US Class Current: 607/2
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more intracranial (IC) stimulating electrodes in accordance with treatment parameters. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

Claims

1. A system for neural modulation in the treatment of disease, comprising:

(A) a sensor array in electronic communication with a signal conditioning circuit;

(B) a control circuit in electronic communication with said signal conditioning circuit;

(C) an output stage circuit in electronic communication with said control circuit; and

(D) a stimulating electrode array, in electronic communication with said output circuit.

3. A system as recited in claim 1, said control circuit employing a calculation of a measure of chaos.

5. A system as recited in claim 1, said control circuit employing the calculation of entropy.

7. A system as recited in claim 1, said control circuit employing the calculation of a Lyupanov exponent.

9. A system as recited in claim 1, said control circuit employing the calculation of a maximal Lyupanov exponent.

10. A system as recited in claim 1, said control circuit employing the calculation of a maximal Lyupanov exponent.

2. A system for neural modulation in the treatment of disease, comprising:

(A) a sensor array in electronic communication with a control circuit;

(B) an output stage circuit in electronic communication with said control circuit; and

(C) a stimulating electrode array, in electronic communication with said output circuit.

4. A system as recited in claim 2, said control circuit employing a calculation of a measure of chaos.

6. A system as recited in claim 2, said control circuit employing the calculation of entropy.

8. A system as in claim 2, said control circuit employing the calculation of a Lyupanov exponent.

11. A system for neural modulation in the treatment of disease, comprising:

(A) a system enclosure, in mechanical communication with calvarium;

(B) a control circuit enclosed within said system enclosure and in electronic communication with an output stage;

(C) a stimulating electrode array, in electronic communication with said output circuit.

15. A system as recited in claim 11, wherein said system enclosure enclosing at least one of sensor array, control circuit, output stage, and stimulating electrode array.

19. A system as recited in claim 11, wherein said control circuit employing the calculation of a measure of chaos.

20. A system as recited in claim 11, wherein said control circuit employing the calculation of entropy.

21. A system as recited in claim 11, wherein said control circuit employing the calculation of a Lyupanov exponent.

22. A system as recited in claim 11, wherein said control circuit employing the calculation of a maximal state control.

23. A system as recited in claim 11, said control circuit employing the calculation of seizure prediction.

12. A system for neural modulation in the treatment of disease, comprising:

(A) a system enclosure, in mechanical communication with calvarium;

(B) a sensor array in electronic communication with a control circuit;

(C) an output stage circuit in electronic communication with said control circuit; and

(D) a stimulating electrode array, in electronic communication with said output circuit.

16. A system as in claim 12, wherein said system enclosure enclosing at least one of sensor array, control circuit, output stage, and stimulating electrode array.

13. A system for neural modulation in the treatment of disease, comprising:

(A) a system enclosure, in mechanical communication with calvarium;

(B) a sensor array in electronic communication with said signal conditioning circuit;

(C) a control circuit in electronic communication with said signal conditioning circuit;

(D) an output stage circuit in electronic communication with said control circuit; and

(E) a stimulating electrode array, in electronic communication with said output circuit.

17. A system as recited in claim 13, wherein said system enclosure enclosing at least one of sensor array, control circuit, output stage, and stimulating electrode array.

14. A system for neural modulation in the treatment of disease, comprising:

(A) a system enclosure, in mechanical communication with calvarium;

(B) a sensor array in electronic communication with a signal conditioning circuit;

(C) a signal processor in electronic communication with said signal conditioning circuit;

(D) a control circuit in electronic communication with said signal processor;

(E) an output stage circuit in electronic communication with said control circuit; and

(F) a stimulating electrode array, in electronic communication with said output circuit.

18. A system as recited in claim 14, wherein said system enclosure enclosing at least one of sensor array, control circuit, output stage, and stimulating electrode array.