Device and method to promote neurogenesis
First Claim
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1. An implantable medical device comprising:
- a housing;
an electrical signal generator disposed in the housing;
a pump disposed in the housing;
a reservoir operably coupled to the pump; and
one or more stem cell enhancing agents disposed in the reservoir, the one or more stem cell enhancing agents configured to promote the proliferation, migration, differentiation, or integration of a stem cell.
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Abstract
Devices and methods for treating diseases associated with loss of neuronal function are described. The methods are designed to promote proliferation, differentiation, migration, or integration of endogenous progenitor stem cells of the central nervous system (CNS). A therapy, such as an electrical signal or a stem cell enhancing agent, or a combination of therapies, is applied to a CNS region containing endogenous stem cells or a CNS region where the endogenous stem cells are predicted to migrate and eventually reside, or a combination thereof.
105 Citations
52 Claims
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1. An implantable medical device comprising:
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a housing;
an electrical signal generator disposed in the housing;
a pump disposed in the housing;
a reservoir operably coupled to the pump; and
one or more stem cell enhancing agents disposed in the reservoir, the one or more stem cell enhancing agents configured to promote the proliferation, migration, differentiation, or integration of a stem cell. - View Dependent Claims (2, 3)
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4. A method for treating a disease associated with a loss of neuronal function in a subject in need thereof, the method comprising:
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implanting a first therapy delivery element comprising a therapy delivery region in the subject;
positioning the therapy delivery region of the first therapy delivery element in a first CNS region containing endogenous stem cells;
implanting a second therapy delivery element comprising a therapy delivery region in the subject;
positioning the therapy delivery region of the second therapy delivery element in a second CNS region where the endogenous stem cells are predicted to migrate and integrate;
applying a first therapy to the first CNS region via the therapy delivery region of the first therapy delivery element, the first therapy configured to promote the endogenous stem cells to proliferate, migrate, or differentiate; and
applying a second therapy to the first CNS region via the therapy delivery region of the second therapy delivery element, the second therapy configured to promote one or more of;
(a) proliferation of the endogenous stem cells;
(b) differentiation of the endogenous stem cells;
(c) migration of the endogenous stem cells to the second CNS region;
(d) integration of the endogenous stem cells in the second CNS region cells, wherein the first therapy delivery element is a catheter or a lead and the therapy delivery region of the first therapy element is an infusion section or an electrode, wherein the second therapy delivery element is a catheter or a lead and the therapy delivery region of the second therapy delivery element is an infusion section or an electrode, and wherein the first therapy and the second therapy are the same or different. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method for treating a disease associated with loss of neuronal function in a subject in need thereof, the method comprising:
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applying first therapy to a first CNS region containing endogenous stem cells, the first therapy configured to promote the endogenous stem cells to proliferate, migrate, differentiate, or a combination thereof; and
applying a second therapy to a second CNS region where the endogenous stem cells are predicted to migrate and integrate, the second therapy is configured to promote one or more of;
(a) proliferation of the endogenous stem cells (b) migration of the endogenous stem cells to the second CNS region;
(b) differentiation of the endogenous stem cells;
or(d) integration of the endogenous stem cells in the second CNS region cells, wherein the first therapy and the second therapy are the same or different.
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33. A method for treating a disease associated with a loss of neuronal function in a subject in need thereof, the method comprising:
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implanting a lead comprising an electrode within the subject;
positioning the electrode in communication with a CNS region containing endogenous stem cells;
implanting a catheter comprising an infusion section within the subject;
positioning the electrode in communication with the CNS region containing the endogenous stem cells;
applying an electrical signal via the electrode to the CNS region containing the endogenous stem cells; and
applying a stem cell enhancing agent via the infusion section to the CNS region containing the endogenous stem cells, wherein the electrical stimulation and the stem cell enhancing agent are configured to promote one or more of;
(a) proliferation of the endogenous stem cells;
(b) migration of the endogenous stem cells;
or(c) differentiation of the endogenous stem cells. - View Dependent Claims (34, 35, 36, 37, 38, 39)
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40. A method for treating a disease associated with a loss of neuronal function, the method comprising:
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applying an electrical signal to a CNS region containing endogenous stem cells; and
applying a stem cell enhancing agent to the CNS region containing endogenous stem cells, wherein the electrical signal and the stem cell enhancing agent are configured to promote proliferation, migration, or differentiation of the endogenous stem cells.
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41. A method for treating a disease associated with a loss of neuronal function in a subject in need thereof, the method comprising:
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implanting a lead comprising an electrode in the subject;
positioning the electrode in a CNS region where endogenous stem cells are predicted to migrate and reside;
implanting a catheter comprising an infusion section in the subject;
positioning the infusion section in the CNS region where the endogenous stem cells are predicted to migrate and reside;
applying an electrical signal to the CNS region where the endogenous stem cells are predicted to migrate and reside; and
applying a stem cell enhancing agent to the CNS region where the endogenous stem cells are predicted to migrate and reside, wherein the electrical signal and the stem cell enhancing agent are configured to promote one or more of;
(a) proliferation of the endogenous stem cells;
(b) migration of the endogenous stem cells to the CNS region;
(c) differentiation of the endogenous stem cells;
or(d) integration of the endogenous stem cells in the CNS region. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50)
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51. A method for treating a disease associated with a loss of neuronal function, the method comprising:
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applying an electrical signal to a CNS region where endogenous stem cells are predicted to migrate and reside; and
applying a stem cell enhancing agent to the CNS region where endogenous stem cells are predicted to migrate and reside, wherein the electrical signal and the stem cell enhancing agent are configured to promote one or more of;
(a) proliferation of the endogenous stem cells;
(b) migration of the endogenous stem cells to the CNS region;
(c) differentiation of the endogenous stem cells;
or(d) integration of the endogenous stem cells in the CNS region. - View Dependent Claims (52)
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Specification