Wound dressings and methods

• US 20050123590A1
• Filed: 12/05/2003
• Published: 06/09/2005
• Est. Priority Date: 12/05/2003
• Status: Abandoned Application

• Current Assignee: 3M Innovative Properties Company (3M Company)
• Original Assignee: 3M Innovative Properties Company (3M Company)
• Inventors: Popko, Daniel T., Burton, Scott A., Hyde, Patrick D.
• Application Number:
  US10/729,114
• Publication Number:
  US 20050123590A1
• Time in Patent Office: Days
• US Class Current: 424/445
• CPC Class Codes: A61L 15/225 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 15/425 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 15/585 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 15/60 Liquid-swellable gel-forming materials, e.g. super-absorbents
• CPC Class Codes: C08L 101/025 containing nitrogen atoms

Abstract

A wound dressing that includes apertured, liquid permeable substrate and an absorbent, nonadherent polymer composition comprising: a hydrophobic organic polymer matrix; an optional plasticizing agent; and hydrophilic organic microparticles.

Claims

1. A wound dressing comprising an apertured liquid permeable substrate and an absorbent, nonadherent polymer composition comprising:

a hydrophobic organic polymer matrix;

an optional plasticizing agent; and

hydrophilic organic microparticles.

2. The wound dressing of claim 1 wherein the hydrophobic organic polymer matrix comprises a styrene-isoprene-styrene copolymer, a styrene-butadiene-styrene copolymer, or mixtures thereof.

3. The wound dressing of claim 1 wherein the composition comprises a plasticizing agent.

4. The wound dressing of claim 1 wherein the microparticles when in a substantially nonhydrated form have an average particle size of 10 microns or less.

5. The wound dressing of claim 4 wherein the microparticles when in a substantially nonhydrated form have an average particle size of 1 micron or less.

6. The wound dressing of claim 5 wherein the microparticles when in a substantially nonhydrated form have an average particle size of 0.5 micron or less.

7. The wound dressing of claim 1 wherein the apertured liquid permeable substrate comprises 1 to 225 apertures per square centimeter.

8. The wound dressing of claim 1 wherein the apertured liquid permeable substrate comprises apertures having an average opening size of 0.1 millimeter to 0.5 centimeter.

9. The wound dressing of claim 1 wherein the microparticles comprise an amine-containing organic polymer.

10. The wound dressing of claim 9 wherein the amine-containing organic polymer microparticles comprise a quaternary ammonium salt of an organic polymer.

11. The wound dressing of claim 10 wherein the microparticles comprise a cationic homopolymer of the methyl chloride quaternary salt of 2-(dimethylamino)ethyl methacrylate.

12. The wound dressing of claim 1 wherein the microparticles comprise a copolymer of sodium acrylate and acrylic acid.

13. The wound dressing of claim 1 wherein the microparticles are in the form of a dispersion.

14. The wound dressing of claim 1 wherein the polymer composition further comprises a bioactive agent.

15. The wound dressing of claim 14 wherein the bioactive agent is an antimicrobial agent.

16. The wound dressing of claim 1 wherein the polymer composition further comprises an additive selected from the group consisting of a tackifier, a crosslinking agent, a stabilizer, a compatibilizer, an extruding aid, a filler, a pigment, a dye, a swelling agent, a chain transfer agent, and combinations thereof.

17. The wound dressing of claim 1 wherein the hydrophobic organic polymer matrix comprises a mixture of two or more polymers.

18. The wound dressing of claim 1 wherein the microparticles are present in an amount of 1 wt-% to 60 wt-%, based on the total weight of the polymer composition.

21. A method of treating a wound, the method comprising applying the wound dressing of claim 1 to the wound.

19. A wound dressing comprising an apertured liquid permeable substrate and an absorbent, nonadherent polymer composition comprising:

a hydrophobic organic polymer matrix comprising a styrene-isoprene-styrene copolymer, a styrene-butadiene-styrene copolymer, or mixtures thereof;

an optional plasticizing agent; and

hydrophilic microparticles comprising an amine-containing organic polymer.

22. A method of treating a wound, the method comprising applying the wound dressing of claim 19 to the wound.

20. A wound dressing comprising an apertured liquid permeable substrate and an absorbent, nonadherent polymer composition comprising:

a hydrophobic organic polymer matrix comprising a styrene-isoprene-styrene copolymer, a styrene-butadiene-styrene copolymer, or mixtures thereof;

an optional plasticizing agent; and

hydrophilic microparticles comprising a sodium polyacrylate copolymer.

23. A method of treating a wound, the method comprising applying the wound dressing of claim 20 to the wound.