Antibodies specific for toxic amyloid beta protein oligomers
First Claim
1. A composition comprising a purified monoclonal antibody that identifies soluble, non-fibrillar oligomeric amyloid β
- protein assemblies.
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Accused Products
Abstract
The present invention provides compositions and methods for diagnosing Alzheimer'"'"'s disease (AD). In particular, the present invention provides monoclonal antibodies that specifically bind to soluble, non-fibrillar oligomeric amyloid β protein assemblies proteolytically derived from the transmembrane amyloid precursor protein (APP) while not reacting with fibrillar amyloid β protein assemblies, monoclonal antibodies that specifically bind to fibrillar amyloid β protein assemblies that do not react with soluble, non-fibrillar oligomeric amyloid β protein assemblies, and methods of use of these compositions in the diagnosis of Alzheimer'"'"'s disease, as well as methods to monitor treatment and/or disease progression of AD in patients.
60 Citations
19 Claims
-
1. A composition comprising a purified monoclonal antibody that identifies soluble, non-fibrillar oligomeric amyloid β
- protein assemblies.
- View Dependent Claims (2, 3, 4)
-
5. A composition comprising a purified monoclonal antibody suitable for identification of fibrillar amyloid β
- protein assemblies that does not identify soluble, non-fibrillar oligomeric amyloid β
protein assemblies. - View Dependent Claims (6, 7, 8)
- protein assemblies that does not identify soluble, non-fibrillar oligomeric amyloid β
-
9. A method for detecting at least one amyloid β
- protein assembly, comprising the steps of;
a) providing i) a sample from a subject suspected of containing at least one amyloid β
protein assembly; and
ii) an antibody that identifies amyloid β
protein assemblies;
b) contacting said sample with said antibody under conditions such that said antibody binds to said amyloid β
protein assembly, forming an antigen-antibody complex; and
c) detecting the presence of said antigen-antibody complex. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- protein assembly, comprising the steps of;
Specification