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Polymer grafting by polysaccharide synthases

  • US 20050124046A1
  • Filed: 07/16/2002
  • Published: 06/09/2005
  • Est. Priority Date: 04/02/1998
  • Status: Active Grant
First Claim
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1. A method for elongating a functional acceptor, comprising the steps of:

  • providing a functional acceptor, wherein the functional acceptor has at least two sugar units selected from the group consisting of GlcUA, GlcNAc, and hexosamine, and wherein the functional acceptor is attached to a substrate selected from the group consisting of silica, silicon, glass, polymers, organic compounds, metals and combinations thereof;

    providing a hyaluronic acid synthase capable of elongating the functional acceptor, wherein the hyaluronic acid synthase has an amino acid sequence encoded by a nucleotide sequence capable of hybridizing under standard conditions to a nucleotide sequence encoding the hyaluronic acid synthase as set forth in SEQ ID NO;

    1; and

    providing UDP-GlcUA and UDP-GlcNAc sugars such that the hyaluronic acid synthase elongates the functional acceptor.

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