Polymer compositions with bioactive agent, medical articles, and methods
First Claim
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1. A polymer composition comprising:
- a hydrophilic polymer; and
a bioactive agent selected from the group consisting of a metal oxide of silver, copper, zinc, and combinations thereof;
wherein the bioactive agent is dispersed within the hydrophilic polymer; and
wherein substantially all of the bioactive agent has a particle size less than one micron.
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Abstract
A polymer composition that includes a hydrophilic polymer, an optional secondary organic polymer, and a bioactive agent distributed therein, wherein the bioactive agent is selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof.
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Citations
93 Claims
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1. A polymer composition comprising:
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a hydrophilic polymer; and
a bioactive agent selected from the group consisting of a metal oxide of silver, copper, zinc, and combinations thereof;
wherein the bioactive agent is dispersed within the hydrophilic polymer; and
wherein substantially all of the bioactive agent has a particle size less than one micron. - View Dependent Claims (2, 3, 4, 5, 6, 46, 47, 48, 49, 60, 61)
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7. A polymer composition preparable by a method comprising combining components comprising:
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a hydrophilic polymer;
a metal compound selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof, wherein the silver compound has a solubility of at least 0.1 gram per liter in water; and
a hydroxide source that converts the metal compound to the corresponding metal oxide;
wherein the components are combined in a manner to disperse the metal oxide within the hydrophilic polymer. - View Dependent Claims (8, 9, 10, 11, 12, 50, 59, 89, 90)
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13. A polymer composition preparable by a method comprising combining components comprising:
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a hydrophilic polymer;
an ammonia source;
a metal oxide selected from the group consisting of silver oxides, copper oxides, zinc oxide, and combinations thereof;
wherein the components are combined in a manner to disperse the metal oxide within the hydrophilic polymer; and
wherein the metal oxide particle size is less than one micron. - View Dependent Claims (14, 15, 16, 17, 18, 91, 92, 93)
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19. A composition preparable by a method comprising combining components comprising:
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a dispersion comprising absorbent hydrophilic microparticles, wherein the microparticles when in a substantially nonhydrated form have an average particle size of 10 microns or less;
a metal compound selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof, wherein the silver compound has a solubility in water of at least 0.1 gram per liter in water; and
a hydroxide source that converts the metal compound to the corresponding metal oxide;
wherein the components are combined in a manner to produce a polymer composition wherein the metal oxide is incorporated within the microparticles. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26)
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27. A polymer composition preparable by a method comprising combining components comprising:
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an organic polymer matrix;
a dispersion comprising absorbent hydrophilic microparticles, wherein the microparticles when in a substantially nonhydrated form have an average particle size of 10 microns or less;
a metal compound selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof, wherein the silver compound has a solubility of at least 0.1 gram per liter in water; and
a hydroxide source that converts the metal compound to the corresponding metal oxide;
wherein the components are combined in a manner to produce a polymer composition wherein the metal oxide is incorporated within the microparticles. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 51, 52, 53, 54, 55, 56, 57, 58, 67)
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62. A method of making a polymer composition, wherein the method comprises:
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combining a dispersion comprising hydrophilic organic microparticles with water and a metal compound under conditions effective to distribute substantially all of the metal compound in the hydrophilic organic microparticles, wherein the metal compound is selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof;
wherein the silver compound has a solubility in water of at least 0.1 gram per liter in water;
adding a hydroxide source to convert the metal compound to the corresponding metal oxide;
optionally adding a secondary organic polymer to the dispersion; and
optionally removing a substantial portion of the water. - View Dependent Claims (63, 64, 65)
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66. A method of making a polymer composition, wherein the method comprises:
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combining monomers for a hydrophilic organic polymer with a metal compound under conditions effective to polymerize the monomers and distribute substantially all of the metal compound within the hydrophilic organic polymer, wherein the metal compound is selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof;
wherein the silver compound has a solubility in water of at least 0.1 gram per liter in water;
adding a hydroxide source to convert the bioactive agent to the corresponding metal oxide; and
optionally adding a secondary organic polymer to the hydrophilic organic polymer.
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68. A medical article comprising a substrate impregnated with one or more metal oxides of silver, copper and zinc wherein the impregnated substrate has less than 1 N/cm peel strength to steel and does not adhere to wound tissue.
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69. A medical article comprising a substrate impregnated with one or more metal oxides of silver, copper and zinc with an average particle size less than 1 micron dispersed within a hydrocolloid.
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70. A method of forming silver oxide in a hydrocolloid, the method comprising:
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providing a mixture of a hydrocolloid and a solution of the silver compound with a solubility of at least 0.1 gram per liter in water;
adding a hydroxide source to form an metal oxide of silver (I);
wherein the silver oxide is dispersed within the hydrocolloid. - View Dependent Claims (71, 72, 73, 74)
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75. A polymer composition comprising:
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a hydrophilic polymer; and
a silver oxide;
wherein the silver oxide is dispersed within the hydrophilic polymer; and
wherein substantially all of the silver oxide has a average particle size less than one micron.
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76. A method of making a polymer composition comprising:
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combining a hydrophilic polymer, a metal compound selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof, wherein the silver compound has a solubility in water of at least 0.1 gram per liter in Water; and
a hydroxide source that converts the metal compound to the corresponding metal oxide; and
dispersing the metal oxide within the hydrophilic polymer. - View Dependent Claims (77, 78, 79, 80, 81, 82, 83)
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84. A method of making a polymer composition, comprising:
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combining a hydrophilic polymer;
an ammonia source; and
a metal oxide selected from the group consisting of silver oxides, copper oxides, zinc oxides, and combinations thereof; and
dispersing the metal oxide within the hydrophilic polymer;
wherein the metal oxide particle size is less than one micron. - View Dependent Claims (85, 86, 87, 88)
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Specification