Thyroid hormone analogs and methods of use
First Claim
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1. A method of treating a condition amenable to treatment by promoting angiogenesis, said method comprising administering to a subject in need thereof an amount of a thyroid hormone, thyroid hormone analog, or polymeric forms thereof, effective for promoting angiogenesis in said subject.
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Abstract
Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of thyroid hormone, or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
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Citations
40 Claims
- 1. A method of treating a condition amenable to treatment by promoting angiogenesis, said method comprising administering to a subject in need thereof an amount of a thyroid hormone, thyroid hormone analog, or polymeric forms thereof, effective for promoting angiogenesis in said subject.
- 19. A method for promoting angiogenesis along or around a medical device, said method comprising coating the device with a thyroid hormone, thyroid hormone analog, or polymeric forms thereof, prior to inserting the device into a patient.
- 22. A method for treating a condition amenable to treatment by inhibiting angiogenesis, said method comprising administering to a subject in need thereof an amount of an anti-angiogenesis agent effective for inhibiting angiogenesis in said subject.
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28. An angiogenic agent comprising a thyroid hormone or analog thereof.
- 29. An angiogenic agent comprising a thyroid hormone or analog thereof conjugated to a polymer.
Specification