Drug profiling apparatus and method

• US 20050124863A1
• Filed: 09/20/2004
• Published: 06/09/2005
• Est. Priority Date: 06/28/2001
• Status: Abandoned Application

• Current Assignee: Daniel R. Cook
• Original Assignee: Daniel R. Cook
• Inventors: Cook, Daniel R.
• Application Number:
  US10/946,369
• Publication Number:
  US 20050124863A1
• Time in Patent Office: Days
• US Class Current: 600/300
• CPC Class Codes: A61B 5/245 specially adapted for magnetoencephalographic [MEG] signals
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: G16H 10/20 for electronic clinical trials or questionnaires
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients

Abstract

A method for assessing a condition of an organism having body waves corresponding to states of the organism. The method may include the step of recording signals corresponding to a body wave, output by a portion of the organism in a first state, to provide a first record. In a similar manner, signals may be recorded during a time period in which the organism is in a second state, to provide a second record. The first and second records, may be processed by applying feature expansion procedures thereto. The results of the feature expansion procedures may be evaluated to identify first selected feature expansion procedures effective to distinguish values of the first signals corresponding to the first state from values of the first signals corresponding to the second state.

Claims

1. A method for assessing a condition of a first organism having body waves corresponding to states of the organism, the method comprising:

recording first signals corresponding to a body wave, output by a portion of the first organism in a first state, to provide a first record;

recording the first signals, during a time period in which the first organism is in a second state, to provide a second record;

processing the first and second records by applying feature expansion procedures thereto; and

evaluating results of the feature expansion procedures to identify first selected feature expansion procedures effective to distinguish values of the first signals corresponding to the first state from values of the first signals corresponding to the second state.

2. The method of claim 1, further comprising providing a signal interpretation map reflecting the first selected feature expansion procedures.

3. The method of claim 1, further comprising:

recording a third record corresponding to a third state;

applying the first selected feature expansion procedures;

classifying the third state as correlating to one of the first and second states.

4. The method of claim 3, wherein the third state is selected from:

a condition selected to be comparable to one of the first and second states of the first organism;

an unidentified state of the first organism;

an unidentified state resulting from a second organism, distinct from the first organism, being in a condition to be compared to one of the first and second states of the first organism; and

an unidentified state of the second organism.

5. The method of claim 1, further comprising:

providing a third record extending over a time period corresponding to transition of the organism between the first and second states; and

applying the first selected feature expansion procedures.

6. The method of claim 5, further comprising identifying a transition time corresponding to a transition between the first and second states.

7. The method of claim 6, wherein identifying a transition time further comprises creating an activation value plot reflecting classifications of portions of the third record as corresponding to the first and second states.

8. The method of claim 7, wherein identifying further comprises determining a time after which the third record reflects that transition is substantially complete between the first and second states.

9. The method of claim 1, further comprising administering a chemical compound to the first organism.

10. The method of claim 9, wherein the first state corresponds to a first amount of the chemical compound and the second state corresponds to a second amount of the chemical compound.

11. The method of claim 9, wherein the first state corresponds to a first time after administration of the chemical compound, and the second state corresponds to a second time after administration of the chemical compound.

12. The method of claim 9, wherein the first state corresponds to a first chemical compound, and the second state corresponds to a second chemical compound.

13. The method of claim 9, wherein the first state corresponds to a first time, previous to administration of the chemical compound, and the second state corresponds to a second time, after administration of the chemical compound.

14. The method of claim 9, wherein the chemical compound is unapproved by a responsible regulatory agency as a therapeutic.

15. The method of claim 1, further comprising providing a signal interpretation map reflecting the selected feature expansion procedures.

16. The method of claim 1, wherein processing further comprises:

recording expansion values output from a feature expansion process applied to the first and second records;

classifying the expansion values in accordance with the correspondence thereof to the first and second states;

comparing a first set of expansion values corresponding to the first state against a second set of expansion values corresponding to the second state; and

selecting a threshold value effective to distinguish expansion values corresponding to the first state from expansion values corresponding to the second state.

17. The method of claim 1, further comprising:

recording second signals corresponding to third and fourth states;

making third and fourth records corresponding to the third and fourth states, respectively;

processing the third and fourth records; and

evaluating the processing of the third and fourth records to identify second selected feature expansion procedures effective to distinguish values of the second signals corresponding to the third state from values of the second signals corresponding to the fourth state.

18. The method of claim 16, further comprising generating a similarity matrix reflecting correspondence between records associated with the first, second, third, and fourth states.

19. The method of claim 1 wherein the organism is selected from a plant, an animal, a human, and a microbe.

20. A method for predicting the physiological effect of a compound on an organism, the method comprising:

providing a signal interpretation map corresponding to a first compound and a first organism;

administering a test compound to the first organism;

monitoring signals propagated from the first organism;

analyzing the signals using first selected feature expansion procedures to form signal feature expansions corresponding to the signals;

classifying the signals in accordance with the signal interpretation map applied to the signal feature expansions; and

predicting a physiological effect of the test compound on the organism based on the classifying.