Method for protecting implantable sensors and protected implantable sensors
First Claim
1. A protected sensor comprising a matrix attached to at least a portion of said sensor, wherein said matrix promotes the growth of endothelial cells.
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Accused Products
Abstract
The present invention relates to a protected implantable sensor and methods of making the same. Sensors of the present invention are protected from deposition of extraneous materials or tissue by a non-biological or biological barrier. In embodiments where the sensor is protected by a non-biological barrier, the protected sensor includes a compliant member that forms part of one or more chambers that includes a substantially non-compressible medium disposed within the chamber(s). The medium is in contact with a surface of the sensor and with a second side of the compliant member. In embodiments where the sensor is protected by a biological barrier, the protected sensor is covered entirely or in part by a layer of endothelial cells. The endothelial cells may be attached to the sensor via interaction with an antibody, antigen binding fragment thereof, or small molecule that specifically binds to a ligand on the cell membrane or cell surface of endothelial cells and/or their progenitor cells or one or more extracellular matrix (ECM) molecules to which the desired cells naturally adhere. In specific embodiments, the implantable sensor to be protected a resonating sensor comprising at least one vibratable member.
54 Citations
27 Claims
- 1. A protected sensor comprising a matrix attached to at least a portion of said sensor, wherein said matrix promotes the growth of endothelial cells.
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13. A method of protecting an implanted sensor from biological processes of the body tending to impair sensor function, wherein said biological processes consist of deposition of cells, tissue, or molecules made by cells.
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14. A method for inhibiting deposition of material on a sensor that has been implanted in a patient in need thereof comprising:
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a) coating the sensor or a portion thereof with a matrix, wherein said matrix comprises a first molecule capable of interacting with a second molecule, wherein said second molecule is on the surface of an endothelial cell or a progenitor of said endothelial cell;
b) implanting said sensor in a patient in need thereof. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification