Monitoring thoracic fluid changes

• US 20050124908A1
• Filed: 12/03/2003
• Published: 06/09/2005
• Est. Priority Date: 12/03/2003
• Status: Active Grant

• Current Assignee: Regents of The University of Minnesota (University of Minnesota)
• Original Assignee: Regents of The University of Minnesota (University of Minnesota)
• Inventors: Belalcazar, Andres, Patterson, Robert
• Granted Patent: US 7,184,821 B2
• Time in Patent Office: Days
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/0809 by impedance pneumography
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators

Abstract

Changes in fluid volume in a thoracic region, such as the lung, are detected by internally injecting a current through the region, detecting an induced voltage on the skin of the patient, and calculating an impedance value. A method for performing such a measurement includes injecting an electrical current between first and second internal electrodes that are implanted in the body and that are positioned such that a portion of the injected current flows through at least a portion of the region. The method also includes measuring a voltage between first and second external electrodes attached to an external surface of the skin of the body. The measured voltage is induced by the injected current. The method also includes calculating an impedance by taking the ratio of the measured voltage and the injected current, wherein the calculated impedance is related to the volume of fluid in the region.

Claims

1. A method for performing a measurement related to a volume of fluid in a region inside a thorax of a body, comprising:

injecting an electrical current between first and second internal electrodes positioned such that a portion of the injected current flows through at least a portion of the region, the internal electrodes being implanted in the body;

measuring a voltage between first and second external electrodes, the measured voltage being induced by the injected current, the first and second external electrodes being attached to an external surface of the skin of the body; and

calculating a first impedance by taking the ratio of the measured voltage and the injected current, wherein the calculated impedance is related to the volume of fluid in the region.

2. The method of claim 1, wherein the region is a lung.

3. The method of claim 2, wherein the injection of current is accomplished by applying a voltage between the first and second internal electrodes using an implantable cardiac device.

4. The method of claim 3, wherein the housing of the implantable cardiac device serves as the second internal electrode.

5. The method of claim 4, wherein the first internal electrode is positioned epicardially over the left ventricle of the heart, and the second internal electrode is positioned near the upper portion of the left lung.

6. The method of claim 5, wherein the first external electrode is attached to the anterior left shoulder region near the upper part of the lung, and the second external electrode is attached to the central dorsal region.

7. The method of claim 2, wherein the injection of current is accomplished by applying a voltage between the first and second internal electrodes using an implantable cardiac device.

8. The method of claim 7, wherein the implantable cardiac device is an implantable cardioverter defibrillator.

9. The method of claim 7, wherein the implantable cardiac device is an implantable pacemaker.

10. The method of claim 7, wherein the implantable cardiac device is an implantable cardiac resynchronization therapy device.

11. The method of claim 7, further comprising measuring a lead impedance of the first and second internal electrodes.

12. The method of claim 11, further comprising telemetering a voltage applied to inject the current and the measured lead impedance to a device external to the body.

13. The method of claim 12, further comprising calculating the injected current by dividing the telemetered voltage by the telemetered current.

14. The method of claim 4, further comprising:

injecting a second electrical current between a third internal electrode and the second internal electrode, the third internal electrode being implanted in the body and positioned such that a portion of the injected current flows through at least a portion of the lung;

measuring a second voltage between a third external electrode attached to the upper right shoulder region and another of the external electrodes, the second measured voltage being induced by the second injected electrical current.

15. The method of claim 14, wherein the third internal electrode is positioned in the right atrium of the heart.

16. The method of claim 14 further comprising calculating a second impedance by taking the ratio of the second measured voltage and the second injected current.

17. The method of claim 16, further comprising computing a weighted average of the first and second calculated impedances.

18. The method of claim 17, further comprising comparing two weighted averages to detect changes in pulmonary edema.

19. The method of claim 1, further comprising telemetering information about the injected current to a device external to the body.

20. The method of claim 2, further comprising comparing a number of calculated impedances to detect a change in the volume of fluid in the lung.

21. The method of claim 20, further comprising detecting changes in pulmonary edema corresponding to changes in the calculated impedance.

22. An apparatus for performing a measurement related to a volume of fluid in a region inside a thorax of a body, comprising:

a receiver that receives information about an electrical current injected between first and second internal electrodes positioned such that a portion of the injected current flows through at least a portion of the region, the received information being telemetered from a device that injects the current, the device and the internal electrodes being implanted in the body;

an interface that receives a voltage signal detected by first and second external electrodes attached to an external surface of the skin of the body, the detected voltage being induced by the injected current; and

a processing unit that determines the fluid volume in the region by calculating a first impedance from the voltage signal and the received information about the injected current.

23. The apparatus of claim 22, wherein the region is a lung.

24. The apparatus of claim 23, further comprising an implantable cardiac device that applies a voltage between the first and second internal electrodes to accomplish the current injection.

25. The apparatus of claim 24, wherein a housing of the implantable cardiac device serves as the second internal electrode.

26. The apparatus of claim 25, wherein the first internal electrode is positioned epicardially over the left ventricle of the heart, and the second internal electrode is positioned near the upper portion of the left lung.

27. The apparatus of claim 26, wherein the first external electrode is attached to the anterior left shoulder region of the body, and the second external electrode is attached to the central dorsal region of the body.

28. The apparatus of claim 22, further comprising an implantable cardiac device that applies a voltage between the first and second internal electrodes to accomplish the current injection.

29. The apparatus of claim 28, wherein the implantable cardiac device is an implantable pacemaker.

30. The apparatus of claim 28, wherein the implantable cardiac device is an implantable cardioverter-defibrillator.

31. The apparatus of claim 28, wherein the implantable cardiac device is an implantable cardiac resynchronization therapy device.

32. The apparatus of claim 28, wherein the second internal electrode comprises a housing of the implantable cardiac device.

33. The apparatus of claim 28, wherein the implantable medical device measures a lead impedance of the first and second internal electrodes.

34. The apparatus of claim 33, wherein the received information about the injected current further comprises a telemetered value of the voltage applied to accomplish the current injection and a telemetered value of the measured lead impedance.

35. The apparatus of claim 34, wherein the processing unit calculates the injected current by dividing the telemetered voltage value by the telemetered lead impedance value.

36. The apparatus of claim 25, wherein the receiver receives information about a second electrical current injected between a third internal electrode and the second electrode, the third internal electrode being implanted in the body and positioned such that a portion of the injected current flows through the lung, and wherein the interface receives a second voltage signal detected by a third external electrode and the second external electrode, the third electrode being attached to the skin in the suprasternal notch region, and the second electrode being attached to the postero-lateral region of the right thorax, medially over the ribs.

37. The apparatus of claim 36, wherein the third internal electrode is positioned in the right atrium of the heart.

38. The apparatus of claim 36, wherein the processing unit calculates a second impedance by taking the ratio of the second detected voltage and the second injected current.

39. The apparatus of claim 38, wherein the processing unit computes a weighted average of a number of calculated impedances.

40. The apparatus of claim 39, wherein the processing unit compares two weighted averages to detect changes in pulmonary edema.

41. The apparatus of claim 22, wherein the receiver receives telemetered information about the injected current from an implantable medical device in the body.

42. The apparatus of claim 23, wherein the processing unit compares a number of calculated impedances to detect a change in the volume of fluid in the lung.

43. The apparatus of claim 42, wherein the processing unit detects changes in pulmonary edema corresponding to changes in the calculated impedance of the lung.