Method of sterilizing a biocompatible material

• US 20050129570A1
• Filed: 12/03/2004
• Published: 06/16/2005
• Est. Priority Date: 12/15/2003
• Status: Abandoned Application

• Current Assignee: Nipro Corporation
• Original Assignee: Nipro Corporation
• Inventors: Matsuda, Kazuhisa, Morinaga, Yukihiro, Kamimura, Ryosuke
• Application Number:
  US11/002,486
• Publication Number:
  US 20050129570A1
• Time in Patent Office: Days
• US Class Current: 422/22
• CPC Class Codes: A61L 2/08 Radiation
• CPC Class Codes: A61L 2/081 Gamma radiation
• CPC Class Codes: A61L 2/082 X-rays
• CPC Class Codes: A61L 2/087 Particle radiation, e.g. electron-beam, alpha or beta radiation

Abstract

A method of sterilizing a biocompatible material with which decomposition and deterioration in a process of radiation sterilization can be suppressed by hermetically wrapping the biocompatible material together with a deoxidizer with a nonbreathable wrapping material and subjecting the resultant to radiation sterilization. The method suppresses decomposition and deterioration of the material in a process of radiation sterilization. More particularly, the method can reduce the effects of decomposition and deterioration on decomposition time of the biocompatible material in living organisms.

Claims

1. A method of sterilizing a biocompatible material, characterized by comprising hermetically wrapping the biocompatible material together with a deoxidizer with a nonbreathable wrapping material and subjecting the resultant to radiation sterilization.

2. The method of sterilizing a biocompatible material according to claim 1, wherein the radiation sterilization is either γ

-ray sterilization or electron beam sterilization.

3. The method of sterilizing a biocompatible material according to claim 1, wherein the biocompatible material has a shape selected from a sheet, fiber, woven fabric, non-woven fabric, porous body, tube, or combinations of two or more of these, and is molded from a biopolymer substance and/or a biodegradable polymer substance.

4. The method of sterilizing a biocompatible material according to claim 3, wherein the biopolymer substance comprises polysaccharide, DNA, polypeptide, or collagen.

5. The method of sterilizing a biocompatible material according to claim 3, wherein the biodegradable polymer substance comprises polyamide, polyester, polylactic acid, or polyglycol acid.

6. The method of sterilizing a biocompatible material according to claim 1, characterized in that a biocompatible material molded from collagen and/or hyaluronic acid is wrapped together with a deoxidizer with a nonbreathable wrapping material and the resultant is subjected to radiation-sterilization.

7. The method of sterilizing a biocompatible material according to claim 1, characterized by hermetically wrapping the biocompatible material together with a deoxidizer and a desiccant with a nonbreathable wrapping material and subjecting the resultant to radiation sterilization.