Method for enhancing stem cell trafficking

• US 20050129709A1
• Filed: 09/20/2004
• Published: 06/16/2005
• Est. Priority Date: 05/14/2001
• Status: Abandoned Application

• Current Assignee: Cerule LLC
• Original Assignee: Cerule LLC
• Inventors: Jensen, Gitte S., Drapeau, Christian
• Application Number:
  US10/946,561
• Publication Number:
  US 20050129709A1
• Time in Patent Office: Days
• US Class Current: 424/195.170
• CPC Class Codes: A61K 35/748 Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina algae, microalgae or microphytes A61K36/02
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: Y10S 435/946 using algae

Abstract

Consumption of blue-green algae, or extracts thereof, enhances trafficking or homing of stem cells in animals by inducing a transient increase in the population of stem cells present in the animal'"'"'s circulatory system. The animal may be healthy or suffering some disease or physiological condition.

Claims

1. A method for enhancing stem cell trafficking in a subject, comprising:

administering to the subject a therapeutically effective amount of a blue-green algae, or a component thereof, thereby enhancing stem cell trafficking.

2. The method according to claim 1 where the subject is a mammal.

3. The method according to claim 1 where the subject is a human.

4. The method according to claim 1 where the blue-green algae is administered as dried whole cells.

5. The method according to claim 1 where the blue-green algae is administered as a liquid fresh or frozen whole cells.

6. The method according to claim 1 where the blue-green algae is Aphanizomenon flos aquae.

7. The method according to claim 1 where the blue-green algae is a species of Spirulina.

8. The method according to claim 1 where stem cell trafficking is increased by at least 200% as compared to a control.

9. The method according to claim 8 where stem cell trafficking is increased about 100% to about 500% as compared to a control.

10. The method according to claim 1 where the stem cell is a CD34+ cell.

11. The method according to claim 1 where the subject has suffered a traumatic injury.

12. The method according to claim 1 where the subject has a disease or physiological disorder.

13. The method according to claim 12 where disease or physiological disorder is osteoporosis, Alzheimer'"'"'s disease, cardiac infarction, Parkinson'"'"'s disease, traumatic brain injury, multiple sclerosis, or cirrhosis of the liver.

14. A method for enhancing stem homing in a subject, comprising:

administering to the subject a therapeutically effective amount of a blue-green algae, or a component thereof, thereby enhancing stem cell homing.

15. The method according to claim 14 where the subject is a mammal.

16. The method according to claim 14 where the subject is a human.

17. The method according to claim 14 where the blue-green algae is administered as dried whole cells.

18. The method according to claim 14 where the blue-green algae is Aphanizomenon flos aquae.

19. The method according to claim 14 where stem cell homing is increased by at least 200% as compared to a control.

20. The method according to claim 19 where stem cell homing is increased about 100% to about 500% as compared to a control.

21. The method according to claim 14 where the stem cell is a CD34+ cell.

23. The method of claim 20, wherein the subject has osteoporosis, Alzheimer'"'"'s disease, cardiac infarction, Parkinson'"'"'s disease, traumatic brain injury, multiple sclerosis, or cirrhosis of the liver.

22. A method of treating a subject with a disorder amenable to treatment with stem cells, comprising administering to the subject a therapeutically effective amount of a blue green algae or a component thereof.