Hydrogel entrapping therapeutic agent and stent with coating comprising this

• US 20050129734A1
• Filed: 01/19/2005
• Published: 06/16/2005
• Est. Priority Date: 04/12/1999
• Status: Active Grant

• Current Assignee: Cornell Research Foundation Incorporated (Cornell University)
• Original Assignee: Cornell Research Foundation Incorporated (Cornell University)
• Inventors: Chu, Chih-Chang, Zhang, Yeli, Won, Chee-Youb
• Granted Patent: US 7,138,132 B2
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 9/205 Polysaccharides, e.g. alginate, gums; Cyclodextrin
• CPC Class Codes: C08B 37/0021 Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
• CPC Class Codes: C08G 18/6484 Polysaccharides and derivatives thereof
• CPC Class Codes: C08G 18/8108 having only one isocyanate or isothiocyanate group
• CPC Class Codes: C08G 2210/00 Compositions for preparing hydrogels
• CPC Class Codes: C08L 2666/02 Organic macromolecular compounds, natural resins, waxes or and bituminous materials
• CPC Class Codes: C08L 2666/26 Natural polymers, natural resins or derivatives thereof according to C08L1/00 - C08L5/00, C08L89/00, C08L93/00, C08L97/00 or C08L99/00
• CPC Class Codes: C08L 5/02 Dextran; Derivatives thereof
• CPC Class Codes: C08L 67/07 having terminal carbon-to-carbon unsaturated bonds
• CPC Class Codes: Y10S 525/937 Utility as body contact e.g. implant, contact lens or I.U.D.

Abstract

A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom. In one embodiment, a vascular stent is coated with hydrogel with therapeutic agent entrapped therein.

Claims

1-3. -3. (canceled)

4. Hydrogel-forming system which comprises hydrophobic and hydrophilic components (A) and (B) which are convertible into a one phase crosslinked network structure by free radical polymerization, where the hydrophobic and hydrophilic components constitute different compounds from one another, the hydrophobic component (A) being a hydrophobic macromer with unsaturated group terminated ends, and the hydrophilic component (B) being a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, the hydrogel-forming system comprising from 0.01 to 99.99% by weight of (A) and from 99.99 to 0.01% (B), with the total of the percentages of (A) and (B) leaving 100%.

5. The hydrogel-forming system of claim 4 where the hydrophobic macromer is made from aliphatic polyester starting material.

6. The hydrogel-forming system of claim 4 where the hydrophobic macromer is made from poly (lactic acid) starting material.