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Method and compositions for inhibiting tumorigenesis

  • US 20050130922A1
  • Filed: 08/29/2004
  • Published: 06/16/2005
  • Est. Priority Date: 06/20/1997
  • Status: Abandoned Application
First Claim
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1. A method for inhibiting the synthesis and/or expression and/or activity of a GLI protein in a cell in vitro or in vivo comprising, contacting said cell with or introducing into said cell an inhibitor or antagonist of GLI synthesis and/or expression and/or activity, said inhibitor or antagonist selected from the group consisting of a small molecule inhibitor or antagonist of GLI synthesis and/or expression and/or activity, an antisense molecule or a siRNA molecule that is complementary to at least a part of the sequence of a nucleic acid encoding the GLI protein, antibodies to GLI, and agents that exhibit mimicry to GLI or antagonism to it or control over its production, said contacting or introducing resulting in inhibition of synthesis and/or expression and/or activity of the GLI protein in said cell.

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