Amelioration of cataracts, macular degeneration and other ophthalmic diseases
First Claim
1. A method of treating macular degeneration, retinopathy, glaucoma, presbyopia, conjunctival diseases, eyelid disorders, corneal disease or uveitis in a patient, the method comprising administering to the eye of such patient a composition comprising an ophthalmically acceptable carrier or diluent containing at least one compound having the formula:
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Accused Products
Abstract
Ophthalmically acceptable compositions used in arresting the development of cataract, presbyopia, macular degeneration and other retinopathies, glaucoma, uveitis and various corneal disorders are disclosed. The compositions are also useful as a prophylactic treatment to prevent or delay development of age-related ocular disorders, which include cataracts, presbyopia, glaucoma and macular degeneration. The compositions comprise a pharmaceutically acceptable carrier or diluent and at least one compound having the formula:
- where R1 and R2 are, independently, H or C1 to C3 alkyl;
- R3 and R4 are, independently C1 to C3 alkyl; and
- where R1 and R2, taken together, or R3 and R4, taken together, or both may be cycloalkyl;
- R5 is H, OH, or C1 to C6 alkyl;
- R6 is or C1 to C6 alkyl, alkenyl, alkynyl, or substituted alkyl or alkenyl;
- R7 is C1 to C6 alkyl, alkenyl, alkynyl, or substituted alkyl or alkenyl or where R6 and R7, or R5, R6 and R7, taken together, form a carbocycle or heterocycle having from 3 to 7 atoms in the ring.
60 Citations
67 Claims
- 1. A method of treating macular degeneration, retinopathy, glaucoma, presbyopia, conjunctival diseases, eyelid disorders, corneal disease or uveitis in a patient, the method comprising administering to the eye of such patient a composition comprising an ophthalmically acceptable carrier or diluent containing at least one compound having the formula:
- 21. A method of preventing or delaying development of cataract, presbyopia, glaucoma, age-related macular disorder or other age-related condition of the eye, the method comprising administering to the eye an eyedrop, eye wash or eye ointment comprising an ophthalmically acceptable carrier or diluent containing at least one compound having the formula:
- 39. A method of protecting retinal pigment epithelium against photooxidative damage, the method comprising administering to the eye an eyedrop, eye wash or eye ointment comprising an ophthalmically acceptable carrier or diluent containing at least one compound having the formula:
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57. A method for protecting hair follicles and preventing further hair loss comprising administering to a patient in need thereof a composition comprising a pharmaceutically acceptable carrier or diluent and at least one compound having the formula:
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58. A method for protecting or treating rectal tissue from damage as a result of irradiation therapy comprising administering to a patient in need thereof a composition comprising a pharmaceutically acceptable carrier or diluent and and at least one compound having the formula:
Specification