Method and system for modelling bone structure

• US 20050131662A1
• Filed: 05/11/2004
• Published: 06/16/2005
• Est. Priority Date: 10/17/2001
• Status: Active Grant

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Ascenzi, Maria-Grazia, Kabo, John M.
• Granted Patent: US 7,353,153 B2
• Time in Patent Office: Days
• US Class Current: 703/11
• CPC Class Codes: A61B 2034/105 Modelling of the patient, e.g. for ligaments or bones
• CPC Class Codes: B33Y 50/00 Data acquisition or data processing for additive manufacturing
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing
• CPC Class Codes: G09B 23/30 Anatomical models G09B23/281 - G09B23/288 take precedence

Abstract

The present invention discloses a structural and mechanical model and modeling methods for human bone based on bone'"'"'s hierarchical structure and on its hierarchical mechanical behavior. The model allows for the assessment of bone deformations, computation of strains and stresses due to the specific forces acting on bone during function, and contemplates forces that do or do not cause viscous effects and forces that cause either elastic or plastic bone deformation.

Claims

1. A method of preparing a model of the structural patterns of an osteon, wherein the method comprises:

identifying structural patterns of the osteon;

comparing the structural patterns with collagen bundle and hydroxyapatite orientation; and

comparing the structural patterns with lacunar and canalicular distributions;

wherein the comparison of the structural patterns of the osteon with the collagen bundle and hydroxyapatite orientation and with the distribution of the lacunae and canaliculae generates data; and

wherein the data is compiled in a computer program, and

wherein the structural patterns comprise extinct and bright lamellae, the extinct lamellae having a collagen distribution generally parallel to an osteon axis, and the bright lamellae having a collagen distribution generally transverse to an osteon axis at a midpoint of its thickness.

2. A model of claim 1, wherein the collagen distribution of extinct lamellae is oriented within an angle that ranges from 0 degrees, corresponding to the orientation of the osteon axis, to substantially less than plus or minus about 45 degrees with respect to the osteon axis.

3. A model of claim 2, wherein the collagen distribution of extinct lamellae is oriented within an angle that up to about plus or minus 23 degrees with respect to the osteon axis.

4. A model of claim 1, wherein the collagen distribution of bright lamellae is oriented within an angle that ranges from a midpoint orientation with respect to the osteon axis up to an angle of about plus or minus 45 degrees with respect to the midpoint orientation.

5. A model of claim 2, wherein the collagen distribution of bright lamellae is oriented within an angle that ranges from a midpoint orientation with respect to the osteon axis up to an angle of about plus or minus 45 degrees with respect to the midpoint orientation.

6. A model of claim 3, wherein the collagen distribution of bright lamellae is oriented within an angle that ranges from a midpoint orientation with respect to the osteon axis up to an angle of about plus or minus 45 degrees with respect to the midpoint orientation.

7. A model of claim 5, wherein the model chooses random values for the measurement of the osteon, lamellae, lacunae, canaliculae, or combinations thereof.

8. A method of determining fracture initiation in bone using the model of claim 7.

9. A method of determining fracture propagation in bone using the model of claim 7.

10. A method of determining the quasi-static tensional behavior of osteons wherein said method comprises using the model of claim 7.

11. A method of identifying the requirements of bone reconstruction and prosthesis wherein said method comprises using the model of claim 7.

12. A method for modeling the biological variability of compact bone using the model of claim 7.

13. A model of claim 1, further comprising at least one mechanical or viscoelastic property of the osteon.

14. A model of claim 13, wherein the at least one property of the osteon is selected from the group consisting of collagen content, mucopolysaccharide content, hydroxyapatite content, the collagen bundle orientation relative to the osteon axis, osteocyte content, osteoblast content, and content of porosity fluids.

15. A model of claim 13, wherein the at least one property is selected from the group consisting of angle-of-twist as a function of torque, strain rate, and time.

16. A model of claim 13, wherein the at least one osteon property is a characteristic of at least one of the extinct lamellae, the bright lamellae, the lacunae, and the canaliculae.