Methods for monitoring severity of panic attacks and other rapidly evolving medical events in real time
First Claim
1. A method of recording a medical event in real-time comprising providing a subject an electronic diary for recording one or more aspects of the medical event, wherein the diary electronically records a time at which entries to the diary are made without requiring the subject to input the time of each entry and wherein the diary further prompts the subject to make an entry in the diary at least twice within every 54 minute time period, following activation of the diary by the subject upon the initiation of the medical event, and continuing until deactivation of prompting from the diary.
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Accused Products
Abstract
The present invention provides novel methods of recording a medical event in real-time. One aspect of the invention comprises providing a subject an electronic diary for recording one or more aspects of a medical event, wherein the diary electronically records a time at which entries to the diary are made without requiring the subject to input the time of each entry and wherein the diary further prompts the subject to make an entry in the diary at various time intervals. Other aspects of the invention include methods of determining whether a medical treatment produces a therapeutic effect in a subject using real-time data; methods of measuring response of a subject experiencing panic attack symptoms to a treatment in real-time; and methods of assessing the relative effectiveness in real-time of a first medical treatment and a second medical treatment.
184 Citations
75 Claims
- 1. A method of recording a medical event in real-time comprising providing a subject an electronic diary for recording one or more aspects of the medical event, wherein the diary electronically records a time at which entries to the diary are made without requiring the subject to input the time of each entry and wherein the diary further prompts the subject to make an entry in the diary at least twice within every 54 minute time period, following activation of the diary by the subject upon the initiation of the medical event, and continuing until deactivation of prompting from the diary.
- 11. A method of recording a panic attack in real-time comprising providing a subject an electronic diary for recording one or more aspect of the panic attack, wherein the subject records an entry in the diary at least three times within every 36 minute time period until deactivation of the diary.
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24. A method of determining whether a medical treatment produces a therapeutic effect in a subject using real-time data comprising:
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(a) providing the subject an electronic diary, (b) administering the medical treatment to the subject, and (c) prompting the subject to enter in the diary at least one measure for symptoms being experienced by the subject at least twice within every 54 minute time period after administration of the medical treatment until deactivation of prompting. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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41. A method of measuring response of a subject experiencing panic attack symptoms to a treatment in real-time comprising:
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(a) providing the subject that experiences panic attack symptoms an electronic diary, (b) administering the treatment to the subject when the panic attack symptoms are present, and (c) entering in the diary at least one measure of the symptoms at least twice every 18 minutes after administration of the treatment until deactivation of the diary. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57)
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58. A method of assessing the relative effectiveness of a first medical treatment and a second medical treatment comprising:
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(a) providing an electron diary to a first subject that experiences one or more symptoms to be treated, (b) administering the first medical treatment to the subject experiencing one or more of the symptoms to be treated, (c) entering in the electronic diary in real-time at least one measure of symptoms at least twice every 54 minute time period after administration of the medical treatment until deactivation of the diary, d) repeating the above steps (a)-(c) for the second medical treatment with the first subject or a second subject, and e) comparing diary entries made after administration of the first medical treatment with entries made after administration of the second medical treatment. - View Dependent Claims (59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69)
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70. A method of determining whether a drug composition is more effective in treating panic than a placebo composition comprising:
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(a) providing a diary to a first subject that has been identified as having had the presence of panic attack symptoms;
(b) administering to the first subject experiencing the panic attack symptoms the placebo composition;
(c) entering in the diary a score on a scale that measures panic attack symptoms at least three times every 18 minutes after administration of the placebo composition until deactivation of the diary;
(d) repeating the above steps (a)-(c) for the drug composition with the first subject or with a second subject, (e) comparing the scores entered after administration of the drug composition with the scores entered after administration of the placebo composition and/or the duration of the event after administration of the drug composition with the duration of the event after administration of the of the placebo composition, and (f) correlating a decrease in the duration of the event or in the scores of the symptoms after administration of the drug composition relative to the placebo composition with more effectiveness of the drug than the placebo in treating panic. - View Dependent Claims (71, 72, 73, 74)
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75. The method of claim 75, wherein administering the drug composition comprises the patient inspiring an aerosol.
Specification