Method and apparatus for validation of sterilization process
First Claim
1. A method for verifying sterilization of components in a sterilization system using a low-energy electron-beam comprising the steps of:
- placing a component to be sterilized within a low-energy electron-beam sterilization system onto a component pallet;
determining a minimum sterilization dose which when applied to the component results in a desired sterility assurance level (SAL);
attaching an indicator within the sterilization system as a site to be used to indicate achievement of at least the minimum sterilization dose;
establishing a correlation between a sterilization dose at the component and a dose at the indicator;
exposing the component and indicator to a sterilizing source;
determining the dose at the indicator; and
ascertaining the efficacy of the sterilization dose achieved at the component based on the determined dose at the correlated indicator.
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Abstract
An apparatus, system and method for verifying the achievement of a desired sterility assurance level (SAL) for components manipulated within a low-energy electron beam sterilization chamber. The components are preferably pre-sterilized and connected together in an assembly fashion which creates and maintains the sterility of the connection by subjecting the components to low-energy (less than 300 KeV) electron beam radiation. The verification is completed by measuring the sterilization dose delivered to a sensor, also known as a dosimeter, positioned within the sterilization process to simulate the components.
136 Citations
62 Claims
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1. A method for verifying sterilization of components in a sterilization system using a low-energy electron-beam comprising the steps of:
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placing a component to be sterilized within a low-energy electron-beam sterilization system onto a component pallet;
determining a minimum sterilization dose which when applied to the component results in a desired sterility assurance level (SAL);
attaching an indicator within the sterilization system as a site to be used to indicate achievement of at least the minimum sterilization dose;
establishing a correlation between a sterilization dose at the component and a dose at the indicator;
exposing the component and indicator to a sterilizing source;
determining the dose at the indicator; and
ascertaining the efficacy of the sterilization dose achieved at the component based on the determined dose at the correlated indicator. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A radiation sterilization verification device comprising:
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a dosimeter; and
a first dosimeter block comprising an interior surface with a cavity defined therein wherein the dosimeter is positioned within the cavity. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A system for verifying the sterility of components comprising:
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a sterilization chamber;
a pallet member configured to position a component within the sterilization chamber;
a dosimeter holder having a dosimeter contained therein and detachably affixed to the pallet member;
a low-energy sterilization source configured to deliver a sterilization dose to a component and a correlated dose to the dosimeter within the sterilization chamber;
a verification station for measuring the correlated dose absorbed by the dosimeter within the sterilization chamber. - View Dependent Claims (30, 31, 32)
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33. A radiation sterilization verification device comprising:
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a plurality of dosimeters; and
a first dosimeter block comprising an interior surface with a plurality of cavities defined therein wherein a dosimeter is positioned within each cavity. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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45. An assembly for verifying sterilization of components, the assembly comprising:
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a component pallet configured to carry at least one component, a portion of which at least one component requires sterilization;
a component site defined by the portion of the at least one component requiring sterilization, the site requiring a threshold sterilization dose to achieve sterility of the portion of the at least one component; and
a dosimeter holder positioned approximate the component site and having at least one dosimeter to receive an applied dose which corresponds to a sterilization dose received by the component site. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
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Specification