Continuous glucose monitoring device
First Claim
1. A system for monitoring analyte concentrations comprising:
- an implantable probe;
a reservoir with perfusion fluid connected to an inlet of the probe;
a means for storing multiple test zones which comprise a reagent, wherein the reagent reacts with the analyte to produce a detectable change, an exposure section for exposing at least one of the test zones to receive fluid containing the analyte from an outlet of the probe;
a transport means for transporting the at least one test zones to the exposure section for receiving fluid containing the analyte and for transporting used test zones into a storage section;
a reader unit which reads test zones wetted with fluid containing the analyte, wherein the reader unit produces signals according to the concentration of the analyte in the fluid; and
a processing unit for processing the signals and to calculate the concentration of the analyte in the fluid.
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Accused Products
Abstract
The present invention is generally directed towards devices for sensing a concentration of chemical constituents in body fluid such as interstitial fluid, including but not limited to glucose. The devices also relates to systems for measuring and reporting the concentration of body fluid constituents at time intervals shorter than the physiological response time, thereby providing effectively continuous concentration measurements. The device according to the present invention comprises a probe, a reservoir with perfusion fluid connected to an inlet of the probe, at least one test zones which comprise a reagent, to react with the analyte to produce a detectable change, a reader unit which reads test zones wetted with fluid containing the analyte, where the reader unit produces signals according to the concentration of the analyte in the fluid; and a processing unit for processing the signals and the concentration of the analyte.
211 Citations
19 Claims
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1. A system for monitoring analyte concentrations comprising:
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an implantable probe;
a reservoir with perfusion fluid connected to an inlet of the probe;
a means for storing multiple test zones which comprise a reagent, wherein the reagent reacts with the analyte to produce a detectable change, an exposure section for exposing at least one of the test zones to receive fluid containing the analyte from an outlet of the probe;
a transport means for transporting the at least one test zones to the exposure section for receiving fluid containing the analyte and for transporting used test zones into a storage section;
a reader unit which reads test zones wetted with fluid containing the analyte, wherein the reader unit produces signals according to the concentration of the analyte in the fluid; and
a processing unit for processing the signals and to calculate the concentration of the analyte in the fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A system for monitoring an analyte concentrations comprising:
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an implantable probe;
a magazine for storing multiple single use test elements that receives the analyte to produce a detectable change;
a reservoir with perfusion fluid connected to an inlet of the probe;
an application section for applying fluid containing analyte from an outlet of the probe to at least one of the single use test elements;
a transport means which transports the single use test elements to the application section for receiving fluid containing analyte and for transporting used single use test elements into a storage section;
a reader unit which reads the single use test elements wetted with fluid containing analyte and which produces signals according to the concentration of the analyte in the fluid; and
a processing unit for processing the signals and to calculate the concentration of analyte in the fluid.
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18. A method of determining an effective diffusion constant k representing the membrane behavior of an implanted microdialysis membrane, comprising:
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measuring an analyte concentration of a fluid containing the analyte at different equilibration times; and
comparing said concentration values to obtain the effective diffusion constant k - View Dependent Claims (19)
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Specification