System for infusing insulin to a subject to improve impaired hepatic glucose processing
First Claim
1. A system for infusing insulin to a subject to improve impaired hepatic glucose processing comprising the steps of:
- a. a means for determining a steady baseline circulating glucose level of the subject and obtaining a subsequent circulating glucose level at least every 30 minutes, the steady baseline circulating glucose level being two consecutive circulating glucose levels about 200 milligrams per deciliter measured five minutes apart, b. a carbohydrate containing meal, c. a means for administering a quantity of insulin through an intravenous site until the subsequent circulating glucose level shows an improvement over the steady baseline circulating glucose level, the improvement over the steady baseline circulating glucose level being a 50 milligram per deciliter or more fall from the steady baseline circulating glucose level within two hours of administering the quantity of insulin, the subsequent circulating glucose level improvement over the steady baseline circulating glucose level being a measurement of sufficient quantity of insulin to achieve an improvement in hepatic glucose processing, d. allowing the subject to rest at least one hour, e. repeating steps a-d at least two times.
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Abstract
The present invention is a system for delivering insulin to a subject to improve impaired hepatic glucose processing. The system delivers a series of pulses of insulin to the subject over a period of time accompanied by ingestion of glucose in the form of a carbohydrate containing meal. The amount of insulin in each pulse, the interval between pulses and the amount of time to deliver each pulse to the subject are selected so that the hepatic processing of glucose is restored in the subject. In subjects whose hepatic glucose processing has been restored there is a subsequent fall in circulating blood glucose levels of 50 mg/dl or more directly as a result of improved hepatic glucose processing.
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Citations
19 Claims
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1. A system for infusing insulin to a subject to improve impaired hepatic glucose processing comprising the steps of:
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a. a means for determining a steady baseline circulating glucose level of the subject and obtaining a subsequent circulating glucose level at least every 30 minutes, the steady baseline circulating glucose level being two consecutive circulating glucose levels about 200 milligrams per deciliter measured five minutes apart, b. a carbohydrate containing meal, c. a means for administering a quantity of insulin through an intravenous site until the subsequent circulating glucose level shows an improvement over the steady baseline circulating glucose level, the improvement over the steady baseline circulating glucose level being a 50 milligram per deciliter or more fall from the steady baseline circulating glucose level within two hours of administering the quantity of insulin, the subsequent circulating glucose level improvement over the steady baseline circulating glucose level being a measurement of sufficient quantity of insulin to achieve an improvement in hepatic glucose processing, d. allowing the subject to rest at least one hour, e. repeating steps a-d at least two times. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification