Activatable bioactive implantable medical device and method of use
First Claim
Patent Images
1. A vascular occlusion device comprising:
- a support member;
a compound disposed on said support member which stimulates tissue growth; and
, an outer barrier disposed on said compound to prevent exposure of said compound to bodily fluids when said vascular occlusion device is inserted into a blood vessel, said outer barrier exhibiting the characteristic of being inert to bodily fluid but dissolving when an external agent is applied to said outer barrier.
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Abstract
A medial device, such as a vascular occlusive device, which includes a support element having a compound disposed thereon which stimulates the production of vascular endothelial growth factors, and an outer barrier coating which serves to prevent a reaction between the compound and bodily fluids until the outer barrier is dissolved by applying an external agent to the outer barrier.
20 Citations
50 Claims
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1. A vascular occlusion device comprising:
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a support member;
a compound disposed on said support member which stimulates tissue growth; and
,an outer barrier disposed on said compound to prevent exposure of said compound to bodily fluids when said vascular occlusion device is inserted into a blood vessel, said outer barrier exhibiting the characteristic of being inert to bodily fluid but dissolving when an external agent is applied to said outer barrier. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A vascular occlusion device comprising:
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a support member comprised of a compound which stimulates tissue growth; and
,an outer barrier disposed on said support member to prevent contact between said support member and bodily fluids when said vascular occlusion device is inserted into the body, said outer barrier exhibiting the characteristic of being substantially inert to blood but exposing a portion of said compound when in the presence of an external agent. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A vascular occlusion device comprising:
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a support element comprising a compound which stimulates the production of vascular endothelial growth; and
,an outer barrier comprising an activatable agent, said outer barrier covering said support element and being inert to bodily fluids and exhibiting the characteristics of initially preventing a reaction between the support element and bodily fluids when said vascular occlusion device is inserted into the body and subsequently permitting a reaction between the support element and bodily fluids. - View Dependent Claims (18)
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19. A vascular occlusion device comprising:
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a bioactive support member which when placed within the body stimulates tissue growth when exposed to bodily fluids; and
,a barrier for preventing a reaction between the bioactive support member and bodily fluids when said vascular occlusion device is inserted into the body, said barrier exhibiting the characteristic of being inert to bodily fluids but permitting a reaction between the bioactive support member and bodily fluids when an activating agent is applied to said barrier. - View Dependent Claims (20, 21, 22, 23, 24)
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25. A vascular occlusion device comprising:
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a support element comprised of a compound which stimulates production of vascular endothelial growth factors; and
,an outer barrier disposed on said support element to prevent exposure of said compound to bodily fluid when said vascular occlusion device is inserted into a blood vessel, said outer barrier exhibiting the characteristic of being inert to bodily fluid but dissolving when an external agent is applied to said outer barrier. - View Dependent Claims (26, 27, 28, 29, 30)
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31. A vascular occlusion device comprising:
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a support member;
a stimulation compound which stimulates the production of vascular endothelial growth factors disposed on said support member; and
,an outer barrier disposed on said stimulation compound to prevent contact between said stimulation compound and bodily fluid when said vascular occlusion device is inserted into the body, said outer barrier exhibiting the characteristic of being substantially inert to blood but exposing a portion of said stimulation compound to bodily fluids when in the presence of an external agent. - View Dependent Claims (32, 33, 34)
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35. A vascular occlusion device comprising:
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a support element comprising a compound which stimulates the production of vascular endothelial growth factors; and
,an outer barrier comprising an activatable agent, said outer barrier covering said support element and being inert to bodily fluids and exhibiting the characteristics of initially preventing a reaction between the support element and bodily fluids when said vascular occlusion device is inserted into the body and subsequently permitting a reaction between the support element and bodily fluids. - View Dependent Claims (36, 37, 38)
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39. A vascular occlusion device comprising:
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a bioactive support member which when placed within the body stimulates the production of vascular endothelial growth factors when exposed to bodily fluid; and
,a barrier for preventing a reaction between the bioactive support member and bodily fluids when said vascular occlusion device is inserted into the body, said barrier exhibiting the characteristic of being inert to bodily fluids but permitting a reaction between the bioactive support member and bodily fluids when an activating agent is applied to said barrier. - View Dependent Claims (40, 41, 42)
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43. A medical device comprising:
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a support member;
a stimulation compound which stimulates the production of vascular endothelial growth factors disposed on said support member; and
,an outer barrier disposed on said stimulation compound to prevent exposure of said stimulation compound to bodily fluid when said medical device is inserted into a blood vessel, said outer barrier exhibiting the characteristic of being substantially inert to bodily fluid but dissolving when exposed to an activation agent. - View Dependent Claims (44, 45, 46, 47, 48)
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49. A method of treatment comprising the steps of:
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providing a vascular occlusion device comprising a support member, a stimulation compound which stimulates the production of tissue growth disposed on said support member, and an outer barrier exhibiting the characteristic of normally preventing a reaction between the stimulation compound and bodily fluid and of exposing said stimulation compound to bodily fluids when an external agent is applied to said outer barrier;
inserting a delivery catheter into a blood vessel;
advancing the distal tip of the delivery catheter through the blood vessel until the distal tip is adjacent to a selected site within the blood vessel;
delivering said vascular occlusion device with the delivery catheter at the selected site; and
,applying an external agent through the delivery catheter and into the blood vessel at the site to thereby activate said outer barrier to expose said stimulation compound to bodily fluids to thereby cause a reaction between the stimulation compound and the bodily fluid which in turn causes stimulation of the production of tissue growth.
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50. A method of treatment comprising the steps of:
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providing a vascular occlusion device comprising a support member comprised of a stimulation compound which stimulates the production of growth factors when the support member reacts with bodily fluids and having an outer barrier which exhibits the characteristic of normally inhibiting a reaction between said support member and bodily fluids;
inserting a delivery catheter into a blood vessel;
advancing the distal tip of the delivery catheter through the blood vessel until the distal tip is adjacent a selected site;
delivering said vascular occlusion device with the delivery catheter at the selected site; and
,permitting bodily fluid to react with the support member to thereby expose said support member to bodily fluids to cause a reaction between the support member and bodily fluids in order to cause stimulation of the production of vascular endothelial growth factors.
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Specification