Methods and systems for assessing pulmonary disease with drug therapy control

• US 20050142070A1
• Filed: 09/15/2004
• Published: 06/30/2005
• Est. Priority Date: 09/18/2003
• Status: Abandoned Application

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Stahmann, Jeffrey E., Hartley, Jesse W., Lee, Kent, Ni, Quan
• Application Number:
  US10/943,077
• Publication Number:
  US 20050142070A1
• Time in Patent Office: Days
• US Class Current: 424/45
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/0809 by impedance pneumography
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61M 16/026 specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
• CPC Class Codes: A61M 2230/04 Heartbeat characteristics, e.g. ECG, blood pressure modulation
• CPC Class Codes: A61M 2230/65 Impedance, e.g. conductivity, capacity
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

An external respiratory therapy device incorporates sensors that may be used to sense physiological conditions or parameters associated with pulmonary disease. The sensed conditions may be used to detect and/or to assess a presence of various types of pulmonary diseases. The assessment of the pulmonary disease may be utilized to control a drug therapy delivered to the patient to treat the pulmonary disease.

Claims

1. A method for controlling therapy for a pulmonary disease other than a breathing rhythm disorder, comprising:

sensing one or more conditions associated with the non-rhythm pulmonary disease using sensors of a patient-external respiratory therapy device;

assessing a presence of the non-rhythm pulmonary disease based on the one or more sensed conditions; and

generating a signal for controlling delivery of a drug therapy to treat the non-rhythm pulmonary disease based on the assessment of the non-rhythm pulmonary disease.

2. The method of claim 1, wherein sensing the one or more conditions associated with the non-rhythm pulmonary disease comprises:

performing a pulmonary function test;

determining one or more pulmonary function conditions based on the pulmonary function test.

3. The method of claim 1, further comprising delivering the drug therapy using the control signal.

4. The method of claim 3, wherein delivering the drug therapy comprises delivering the drug therapy using the respiratory therapy device.

5. The method of claim 3, wherein delivering the drug therapy comprises delivering the drug therapy using a therapy device other than the respiratory therapy device.

6. The method of claim 1, wherein:

assessing the presence of the non-rhythm pulmonary disease comprises monitoring a progression of the non-rhythm pulmonary disease; and

generating the control signal for controlling the drug therapy comprises adjusting the control signal based on the progression of the non-rhythm pulmonary disease.

7. The method of claim 1, wherein assessing the presence of the non-rhythm pulmonary disease comprises:

comparing the one or more conditions to one or more sets of threshold criteria; and

assessing the presence of the pulmonary disease based on the comparison.

8. The method of claim 1, further comprising:

sensing one or more additional conditions associated with the non-rhythm pulmonary disease using an implantable device; and

assessing the presence of the non-rhythm pulmonary disease based in part on the one or more additional conditions.

9. A medical system for controlling therapy for a non-breathing rhythm related pulmonary disease, comprising:

an external respiratory therapy device, the external respiratory therapy device comprising;

a therapy unit configured to deliver respiration therapy to a patient; and

a sensor system configured to sense one or more conditions associated with a non-rhythm pulmonary disease; and

a diagnosis unit coupled to the sensor system and configured to assess a presence of the non-rhythm pulmonary disease based on the one or more sensed conditions; and

a drug therapy controller coupled to the diagnosis unit and configured to control a drug therapy delivered to the patient to treat the non-rhythm pulmonary disease.

10. The system of claim 9, wherein the sensor system comprises a ventilation airflow sensor.

11. The system of claim 9, wherein the sensor system comprises a ventilation pressure sensor.

12. The system of claim 9, wherein the sensor system comprises a ventilation gas sensor.

13. The system of claim 9, wherein the diagnosis unit is configured to perform a pulmonary function test and determine one or more pulmonary function conditions based on the pulmonary function test.

14. The system of claim 9, wherein the diagnosis unit is configured to discriminate between two or more of an obstructive pulmonary disease, a restrictive pulmonary disease, and infectious pulmonary disease, a pulmonary vasculature disease, and a pleural cavity disease.

15. The system of claim 9, further comprising an implantable device comprising an additional sensor system comprising one or more additional sensors configured to sense one or more additional conditions associated with the non-rhythm pulmonary disease, wherein the diagnosis unit is configured to assess a presence of an obstructive pulmonary disease using the one or more additional conditions.

16. The system of claim 15, wherein the implantable device comprises an implantable cardiac therapy device.

17. The system of claim 15, wherein the diagnosis unit is configured to perform a pulmonary function test using one or both of the sensor system of the respiratory therapy device and the additional sensor system of the implantable device and to determine one or more pulmonary function conditions based on the pulmonary function test.

18. The system of claim 9, further comprising a drug therapy delivery unit coupled to the drug therapy controller and configured to deliver the drug therapy to the patient.

19. The system of claim 18, wherein the drug therapy delivery unit is a component of the respiratory therapy device and the drug therapy is delivered via the respiratory therapy device.

20. A system for controlling therapy for a pulmonary disease other than a breathing rhythm disorder, comprising:

means for sensing one or more conditions associated with the non-rhythm pulmonary disease using sensors of a patient-external respiratory therapy device;

means for assessing the presence of the non-rhythm pulmonary disease based on the one or more sensed conditions; and

means for generating a control signal for controlling delivery of a drug therapy to treat the non-rhythm pulmonary disease.

21. The system of claim 20, further comprising:

means for performing a pulmonary function test; and

means for determining one or more pulmonary function conditions based on the pulmonary function test.

22. The system of claim 20, further comprising means for delivering the drug therapy using the control signal.

23. The system of claim 20, further comprising means for delivering the drug therapy using the respiratory therapy device.

24. The system of claim 20, further comprising means for delivering the drug therapy using a therapy device other than the respiratory therapy device.

25. The system of claim 20, further comprising:

means for comparing the one or more conditions to one or more sets of threshold criteria; and

means for assessing the presence of the pulmonary disease based on the comparison.

26. The system of claim 20, further comprising:

means for sensing one or more additional conditions associated with the non-rhythm pulmonary disease using an implantable device; and

means for assessing the presence of the non-rhythm pulmonary disease based in part on the one or more additional conditions.