Automatic diagnosing method for autonomic nervous system and device thereof

• US 20050143668A1
• Filed: 08/02/2004
• Published: 06/30/2005
• Est. Priority Date: 12/26/2003
• Status: Abandoned Application

• Current Assignee: Terry B.J. Kuo, We Gene Technologies, Inc.
• Original Assignee: Yamazaki Mazak Corporation
• Inventors: Kuo, Terry B. J., Teng, Chun-Nan, Lin, Ming-Sian, Wei, Cheng-Yu, Lu, Kun-Shan
• Application Number:
  US10/910,094
• Publication Number:
  US 20050143668A1
• Time in Patent Office: Days
• US Class Current: 600/509
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/0245 by using sensing means generating electric signals, i.e. ECG signals
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system

Abstract

An automatic diagnosing method for the autonomic nervous system and a device thereof are described. The device comprises a sensor, a computing device and an output device. An electrode of the sensor is adhered to the skin surface of a subject to detect and output the heart beat signal of the subject. The computing device collects the heart beat signal from the electrodes through the signal collection leads. The computing device further amplifies, filters, digitizes and transforms the heart beat signals into a plurality of heart rate variability parameters. Further, calculations, validation and analysis are performed on these parameters. After selecting a corresponding diagnosis description statement from a lookup table in a database, an examination report, which incorporates the diagnosis description statement and the heart rate variability parameters is output.

Claims

1. An automatic diagnosing method, in which a non-invasive approach is used to diagnosis a function of an autonomic nervous system, the automatic diagnosing method comprising:

inputting a basic information of an user;

measuring a heart beat signal of the user;

transforming the heart beat signal into a plurality of heart rate variability (HRV) parameters;

performing at least a natural logarithm calculation on the heart rate variability parameters to obtain a plurality of natural logarithmic heart rate variability parameters;

using a plurality of reference values in a data base to calculate and optimize the natural logarithmic heart rate variability parameters and to output a plurality of standard deviations of the natural logarithmic HRV parameters;

matching the basic information and the standard deviations with a corresponding diagnosis description statement from a lookup table; and

outputting an examination report that incorporates the heart rate variability parameters, the diagnosis description statement, the basic information and the standard deviations.

2. The method of claim 1, wherein the heart rate variability parameters comprise a peak interval, a low frequency component, a high frequency component, a ratio of low frequency to high frequency and LF %.

3. The method of claim 2, wherein the step of matching the basic information and the standard deviations with the corresponding diagnosis description statement from the lookup table further comprises:

comparing the standard deviation of the peak interval with a plurality of lookup values in the lookup table to obtain a plurality of functional states of the peak interval;

comparing the standard deviation of the natural logarithmic low frequency component with the plurality of the lookup values in the lookup table to obtain a plurality of functional states of the low frequency component;

comparing the standard deviation of the natural logarithmic high frequency component with the plurality of the lookup values in the lookup table to obtain a plurality of functional states of the high frequency component;

comparing the standard deviation of the natural logarithmic ratio of low frequency to high frequency and LF % with the plurality of the lookup values in the lookup table to obtain a plurality of functional states of the ratio of low frequency to high frequency; and

outputting the corresponding diagnosis report based on the functional states of the heart rate variability parameters.

4. The method of claim 1, wherein the step transforming of the heart beat signal into the plurality of the heart rate variability parameters further comprises

digitally converting the heart beat signal and detecting a plurality of peaks of digital heart beat signal;

statistically validating each peak;

calculating a plurality of peak intervals of these peaks and statistically validating each peak interval;

performing a calculation on the peak intervals to obtain the plurality of the heart rate variability parameters.

5. The method of claim 4, wherein the step of performing the calculation on the peak intervals to obtain the plurality of the heart rate variability parameters comprises performing a fast Fourier transform.

6. The method of claim 1, wherein the examination report comprises a physical state index chart of the user, a predisposition of the user'"'"'s health condition, an activity of the autonomic nervous system, an age curve, a heart rate and a suggestion.

7. The method of claim 1, wherein the examination report further comprises a very low frequency component, a total power and a power spectrum density.

8. An automatic diagnosing method for an autonomic nervous system (ANS), in which a non-invasive approach is used for diagnosing the autonomic nervous system, the method comprising

a sensing device, comprising a plurality of electrodes and a plurality of signal collection leads, wherein these electrodes are adhered to a subject to detect and output a heart rate signal of the subject;

a computing device, comprising a data base, wherein the computing device receives the heart beat signal through the signal collection leads, amplifies, filters, digitizes and transforms the heart beat signal to obtain a plurality of heart rate variability (HRV) parameters, performs a calculation and a statistical validation on the HRV parameters, and matches the HRV parameters with a corresponding diagnosis description statement from a look up table in the database; and

an output device, coupled to the computing device to receive and output an examination report that incorporates the diagnosis description statement and the HRV parameters.

9. The method of claim 8, wherein the HRV parameters comprise a peak interval, a low frequency component, a high frequency component and a ratio of low frequency to high frequency.

10. The method of claim 8, wherein the step of transforming the heart rate signals includes performing a fast Fourier transform.

11. The method of claim 8, wherein the diagnosis description statement includes a physical state index chart of the user, a predisposition of the user'"'"'s health condition, an activity of the autonomic nervous system, an age curve, a heart rate and a suggestion.

12. The method of claim 8, wherein the examination report further comprises a very low frequency component, a total power and a power spectrum density.

13. The method of claim 8, wherein the output device comprises a monitor to displace the examination report.

14. The method of claim 8, wherein the output device comprises a printer to print the examination report.

15. The method of claim 8, wherein the output device comprises a compact disk writer to write the examination report on a compact disk.

16. The method of claim 8, wherein the output device further comprises a network system for sending the examination report to a remote terminal.

17. The method of claim 8, wherein the computing device comprises at least an amplifier, a filter and an analog/digital converter.

18. The method of claim 8, wherein the computing device comprises a digital signal processing capability for frequency domain analysis, time domain analysis or nonlinear analysis.

19. The method of claim 8, wherein the HRV parameters comprise a peak interval, a low frequency component, a high frequency component and LF %.