System and method for iontophoretic transdermal delivery of one or more therapeutic agents

• US 20050143686A1
• Filed: 02/17/2005
• Published: 06/30/2005
• Est. Priority Date: 07/29/2002
• Status: Abandoned Application

• Current Assignee: Eemso Incorporated
• Original Assignee: Eemso Incorporated
• Inventors: Shevlin, Daniel P.
• Application Number:
  US11/059,798
• Publication Number:
  US 20050143686A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

In one embodiment, a system for iontophoretic transdermal delivery of one or more therapeutic agents into a user'"'"'s skin includes a first end including a first reservoir for containing one or more therapeutic agents, a second end including a second reservoir for containing one or more therapeutic agents, and a connecting portion coupling the first end to the second end. The connecting portion houses a self-contained power source for generating electric current, the power source having a first terminal and a second terminal. The connecting portion also houses: (1) at least a portion of a first electrode for electrically coupling the first terminal of the power source to the first reservoir, the first electrode operable to conduct electric current between the power source and the first reservoir to ionize the one or more therapeutic agents contained within the first reservoir for iontophoretic transdermal delivery into the user'"'"'s skin; and (2) at least a portion of a second electrode for electrically coupling the second terminal of the power source to the second reservoir, the second electrode operable to conduct electric current between the power source and the second reservoir to ionize the one or more therapeutic agents contained within the second reservoir for iontophoretic transdermal delivery into the user'"'"'s skin. The system is adapted to be used in an extended or non-extended state.

Claims

1. A system for iontophoretic transdermal delivery of one or more therapeutic agents into a user'"'"'s skin, comprising:

a first end comprising a first reservoir adapted to contain one or more therapeutic agents;

a second end comprising a second reservoir adapted to contain one or more therapeutic agents;

the first and second reservoirs each comprising;

a reservoir pad adapted to absorb the therapeutic agents to be delivered to the user; and

a foam reservoir gasket adapted to help contain the therapeutic agents contained in the reservoir pad;

a battery for generating electric current, the battery positioned between the first and second reservoirs and comprising a bottom terminal directed toward a bottom surface of the system and a top terminal directed toward a top surface of the system;

a first substantially flat, substantially straight electrode extending in a first direction from the battery, the first electrode comprising a first end that is electrically coupled to the top terminal of the battery and comprising a second end that is electrically coupled to the one or more therapeutic agents contained in the reservoir pad of the first reservoir, the first electrode operable to conduct electric current between the battery and the first reservoir to promote iontophoretic transdermal delivery of the therapeutic agents contained in the first reservoir into the user'"'"'s skin; and

a second substantially flat, substantially straight electrode extending in a second direction from the battery, the second electrode comprising a first end that is electrically coupled to the bottom terminal of the battery and comprising a second end that is electrically coupled to the one or more therapeutic agents contained in the reservoir pad of the second reservoir, the second electrode operable to conduct electric current between the battery and the second reservoir to promote iontophoretic transdermal delivery of the therapeutic agents contained in the second reservoir into the user'"'"'s skin;

the first and second electrodes and the battery positioned along a substantially straight line between the first end and the second end;

the first and second electrodes lying in substantially the same plane.

2. The system of claim 1, wherein:

the first electrode and the second electrode are each physically connected to the battery; and

a portion of one or both of the first or second electrodes extends from the plane in which the first and second electrodes substantially lie to physically connect to the battery.

3. The system of claim 1, wherein the first and second reservoirs are adapted to each deliver at least one therapeutic agent to the user'"'"'s skin substantially simultaneously.

4. The system of claim 1, further comprising a protective tab associated with each reservoir, each tab adapted to be removably coupled to a hypoallergenic adhesive associated with its reservoir and further adapted to protect and provide protection from the therapeutic agents in its reservoir during application of the system to the user'"'"'s skin, the hypoallergenic adhesive adapted to removably couple the system to a portion of the user'"'"'s body.

5. The system of claim 1, wherein the first electrode, the second electrode, and the battery comprise a flex-circuit.

6. The system of claim 5, further comprising a hidden pocket disposed on the first or second end and adapted to house at least a portion of the flex-circuit when the system is in a non-extended state.

7. The system of claim 1, wherein the first electrode, the second electrode, and the battery are covered by at least one layer of insulating material to protect the user'"'"'s skin.

8. A method for manufacturing a system for iontophoretic transdermal delivery of one or more therapeutic agents into a user'"'"'s skin, comprising:

providing a first reservoir adapted to contain one or more therapeutic agents;

providing a second reservoir adapted to contain one or more therapeutic agents;

providing for each reservoir a reservoir pad adapted to absorb the therapeutic agents to be delivered to the user;

providing for each reservoir a foam reservoir gasket adapted to help contain the therapeutic agents contained in the reservoir pad;

providing a battery for generating electric current, the battery positioned between the first and second reservoirs and comprising a bottom terminal directed toward a bottom surface of the system and a top terminal directed toward a top surface of the system;

providing a first substantially flat, substantially straight electrode extending in a first direction from the battery, the first electrode comprising a first end that is electrically coupled to the top terminal of the battery and comprising a second end that is electrically coupled to the one or more therapeutic agents contained in the reservoir pad of the first reservoir, the first electrode operable to conduct electric current between the battery and the first reservoir to promote iontophoretic transdermal delivery of the therapeutic agents contained in the first reservoir into the user'"'"'s skin;

providing a second substantially flat, substantially straight electrode extending in a second direction from the battery, the second electrode comprising a first end that is electrically coupled to the bottom terminal of the battery and comprising a second end that is electrically coupled to the one or more therapeutic agents contained in the reservoir pad of the second reservoir, the second electrode operable to conduct electric current between the battery and the second reservoir to promote iontophoretic transdermal delivery of the therapeutic agents contained in the second reservoir into the user'"'"'s skin;

positioning the first and second electrodes and the battery along a substantially straight line between the first end and the second end; and

positioning the first and second electrodes lying in substantially the same plane.

9. The method of claim 8, further comprising physically connecting the first electrode and the second electrode to the battery, wherein a portion of one or both of the first or second electrodes extends from the plane in which the first and second electrodes substantially lie to physically connect to the battery.

10. The method of claim 8, wherein the first and second reservoirs are adapted to each deliver at least one therapeutic agent to the user'"'"'s skin substantially simultaneously.

11. The method of claim 8, further comprising providing a protective tab associated with each reservoir, each tab adapted to be removably coupled to a hypoallergenic adhesive associated with its reservoir and further adapted to protect and provide protection from the therapeutic agents in its reservoir during application of the system to the user'"'"'s skin, the hypoallergenic adhesive adapted to removably couple the system to a portion of the user'"'"'s body.

12. The method of claim 8, wherein the first electrode, the second electrode, and the battery comprise a flex-circuit.

13. The method of claim 12, further comprising providing a hidden pocket disposed on the first or second end and adapted to house at least a portion of the flex-circuit when the system is in a non-extended state.

14. The method of claim 8, further comprising providing at least one layer of insulating material disposed about the first electrode, the second electrode, and the battery, the insulating material adapted to protect the user'"'"'s skin.

15. A method for delivering one or more therapeutic agents to a user through the user'"'"'s skin, comprising:

positioning an iontophoretic transdermal delivery system on a portion of the user'"'"'s body to receive treatment, the system comprising;

a first end comprising a first reservoir adapted to contain one or more therapeutic agents;

a second end comprising a second reservoir adapted to contain one or more therapeutic agents;

the first and second reservoirs each comprising;

a reservoir pad adapted to absorb the therapeutic agents to be delivered to the user; and

a foam reservoir gasket adapted to help contain the therapeutic agents contained in the reservoir pad;

a battery for generating electric current, the battery positioned between the first and second reservoirs and comprising a bottom terminal directed toward a bottom surface of the system and a top terminal directed toward a top surface of the system;

a first substantially flat, substantially straight electrode extending in a first direction from the battery, the first electrode comprising a first end that is electrically coupled to the top terminal of the battery and comprising a second end that is electrically coupled to the one or more therapeutic agents contained in the reservoir pad of the first reservoir, the first electrode operable to conduct electric current between the battery and the first reservoir to promote iontophoretic transdermal delivery of the therapeutic agents contained in the first reservoir into the user'"'"'s skin; and

a second substantially flat, substantially straight electrode extending in a second direction from the battery, the second electrode comprising a first end that is electrically coupled to the bottom terminal of the battery and comprising a second end that is electrically coupled to the one or more therapeutic agents contained in the reservoir pad of the second reservoir, the second electrode operable to conduct electric current between the battery and the second reservoir to promote iontophoretic transdermal delivery of the therapeutic agents contained in the second reservoir into the user'"'"'s skin;

the first and second electrodes and the battery positioned along a substantially straight line between the first end and the second end;

the first and second electrodes lying in substantially the same plane;

applying electrical current to any therapeutic agents contained in the reservoirs using the battery; and

delivering the therapeutic agents to the user through the user'"'"'s skin in response to the electrical current.

16. The method of claim 15, wherein:

the first electrode and the second electrode are each physically connected to the battery; and

a portion of one or both of the first or second electrodes extends from the plane in which the first and second electrodes substantially lie to physically connect to the battery.

17. The method of claim 15, wherein the first and second reservoirs are adapted to each deliver at least one therapeutic agent to the user'"'"'s skin substantially simultaneously.

18. The method of claim 15, wherein the system further comprises a protective tab associated with each reservoir, each tab adapted to be removably coupled to a hypoallergenic adhesive associated with its reservoir and further adapted to protect and provide protection from the therapeutic agents in its reservoir prior to application of the system to the user'"'"'s skin, the hypoallergenic adhesive adapted to removably couple the system to the portion of the user'"'"'s body.

19. The method of claim 15, wherein the first electrode, the second electrode, and the battery comprise a flex-circuit.

20. The method of claim 19, wherein the system further comprises a hidden pocket disposed on the first or second end and adapted to house at least a portion of the flex-circuit when the system is in a non-extended state.

21. The method of claim 15, wherein the first electrode, the second electrode, and the battery are covered by at least one layer of insulating material to protect the user'"'"'s skin.