Osteointegrative interface for implantable prostheses and a method for the treatment of the osteointegrative interface
First Claim
1. A biomimetic osteointegrative interface comprising a substrate (3) of biocompatible material such as titanium, tantalum, or their alloys, comprising, on the surface (3bis) of the substrate (3), a first layer (4) having a first concentration of oxide of the biocompatible material, enriched with a second concentration of phosphorus and with a third concentration of calcium, the ratio between the concentration of calcium and the concentration of phosphorus being greater than two, the biomimetic osteointegrative interface (1) further comprising a second layer (5) having a first surface (10) in contact with the first layer (4), and a second surface (11), the second layer (5) having a fourth concentration of oxide enriched with a fifth concentration of calcium and a sixth concentration of phosphorus, the fourth concentration being less than the fifth and sixth concentrations and the ratio between the fifth concentration of calcium and the sixth concentration of phosphorus being no less than three.
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Abstract
A biomimetic osteointegrative interface comprising a substrate of biocompatible material such as titanium, tantalum or their alloys comprising, on the surface of the substrate, a first layer having a first concentration of oxide of the biocompatible material, enriched with a second concentration of phosphorus and with a third concentration of calcium, the ratio between the concentration of calcium and the concentration of phosphorus being greater than two. The biomimetic osteointegrative interface further comprises a second layer having a first surface in contact with the first layer and a second surface. The second layer has a fourth concentration of oxide enriched with a fifth concentration of calcium and a sixth concentration of phosphorus. The fourth concentration is less than the fifth and sixth concentrations and the ration between the fifth concentration of calcium and the sixth concentration of phosphorus is no less than three.
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Citations
23 Claims
- 1. A biomimetic osteointegrative interface comprising a substrate (3) of biocompatible material such as titanium, tantalum, or their alloys, comprising, on the surface (3bis) of the substrate (3), a first layer (4) having a first concentration of oxide of the biocompatible material, enriched with a second concentration of phosphorus and with a third concentration of calcium, the ratio between the concentration of calcium and the concentration of phosphorus being greater than two, the biomimetic osteointegrative interface (1) further comprising a second layer (5) having a first surface (10) in contact with the first layer (4), and a second surface (11), the second layer (5) having a fourth concentration of oxide enriched with a fifth concentration of calcium and a sixth concentration of phosphorus, the fourth concentration being less than the fifth and sixth concentrations and the ratio between the fifth concentration of calcium and the sixth concentration of phosphorus being no less than three.
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4. A method for the biomimetic treatment of an osteointegrative interface on a substrate of biocompatible metal such as titanium, tantalum, or their alloys, comprising the following steps:
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a) performing a first ASD anodic deposition treatment of the osteointegrative interface (1) in a calcium glycerophosphate solution, b) performing a second ASD anodic deposition treatment of the osteointegrative interface (1) in a calcium hydroxide solution, and c) performing an immersion of the osteointegrative interface (1) in a potassium hydroxide solution. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for the biomimetic treatment of an osteointegrative interface on a substrate of biocompatible metal such as titanium, tantalum, or their alloys, comprising the following steps:
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a) performing a first ASD anodic deposition treatment of the osteointegrative interface (1) in a calcium glycerophosphate solution, b) performing a second ASD anodic deposition treatment of the osteointegrative interface (1) in a calcium hydroxide solution, and c) performing an immersion of the osteointegrative interface (1) in a sodium hydroxide solution. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification