Implantable system with drug-eluting cells for on-demand local drug delivery
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Abstract
An implantable system that includes a carrier and eukaryotic cells, which produce and release a therapeutic agent, and a stimulating element for stimulating the release of the therapeutic agent. The system can also include a sensing element for monitoring a physiological condition and triggering the stimulating element to stimulate the delivery device to release the therapeutic agent. Alternatively, the patient in which the system is implanted can activate the stimulating element to release the therapeutic agent.
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Citations
45 Claims
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41. An implantable system comprising:
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(a) a delivery device comprising a carrier and eukaryotic cells that produce at least one therapeutic agent; and
(b) a stimulating element for stimulating the release of the therapeutic agent from the delivery device;
wherein the stimulating element can be activated by a patient in which it is implanted on demand. - View Dependent Claims (42)
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43. A method of local delivery of a therapeutic agent to a patient, the method comprising:
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(a) providing an implantable system comprising;
(i) a delivery device comprising a carrier and eukaryotic cells that produce at least one therapeutic agent; and
(ii) a stimulating element for stimulating the release of the therapeutic agent from the delivery device; and
(b) implanting the implantable system into the body of a patient;
wherein the therapeutic agent is released from the delivery device when the patient detects a change in a physiological condition and communicates with the electrical stimulating element to trigger the release of the therapeutic agent. - View Dependent Claims (44, 45)
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Specification