Inhibitors of proteasomal activity for stimulating hair growth
First Claim
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1. A method to stimulate hair growth in a subject which method comprises administering to the subject benefited by the stimulation of hair growth an effective amount of a composition comprising a statin compound of the formula:
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Abstract
Compounds that inhibit the activity of the proteasome or the production of proteasomal proteins promote hair growth by stimulating the production of hair follicles, and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.
35 Citations
51 Claims
- 1. A method to stimulate hair growth in a subject which method comprises administering to the subject benefited by the stimulation of hair growth an effective amount of a composition comprising a statin compound of the formula:
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40. A pharmaceutical composition in unit dosage form to stimulate hair growth in a subject, comprising a pharmaceutically acceptable excipient and an amount, effective to stimulate hair growth, of a compound of the formula:
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41. A method to identify a compound that is useful in stimulating hair growth in a subject, comprising:
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contacting said compound with an assay mixture for the activity of an enzyme in the isoprenoid pathway;
determining the activity of the enzyme in the presence as compared to the absence of said compound;
wherein a decrease of activity of said enzyme in the presence as opposed to the absence of said compound indicates that the compound will be useful in stimulating hair growth in the subject. - View Dependent Claims (42, 43, 44, 45, 46, 47)
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48. A method to identify a compound useful to stimulate hair growth in vertebrates which method comprises
contacting a candidate compound with an expression system wherein said expression system comprises a control sequence associated with an enzyme in the isoprenoid synthesis pathway operably linked to a reporter gene; -
comparing the expression of the reporter gene in the presence and absence of the compound;
wherein a decrease in the expression of the reporter gene in the presence as compared to the absence of the compound indicates the compound will be useful in stimulating hair growth in vertebrates. - View Dependent Claims (49, 50, 51)
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Specification