Treatment of rheumatoid arthritis with hypoxia inducible factor-1alpha antagonists
First Claim
1. A method of alleviating at least one symptom of rheumatoid arthritis comprising administering a therapeutically effective amount of an antagonist of HIF-1α
- activity to a patient having rheumatoid arthritis.
2 Assignments
0 Petitions
Accused Products
Abstract
The invention encompasses a novel method of treating inflammatory disease, such as rheumatoid arthritis, and novel methods of identifying and screening for drugs useful in the treatment of inflammatory diseases and their clinical symptoms. The inventors have made the discovery that the activity of HIF-1α, a transcription regulator known to have an effect on some cancers, has a significant impact on the pathophysiology of rheumatoid arthritis. The symptoms of an inflammatory disease, such as rheumatoid arthritis, may be alleviated by administering a compound that inhibits the activity of HIF-1α.
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Citations
130 Claims
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1. A method of alleviating at least one symptom of rheumatoid arthritis comprising administering a therapeutically effective amount of an antagonist of HIF-1α
- activity to a patient having rheumatoid arthritis.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of decreasing density of synovial cells in a joint comprising administering a therapeutically effective amount of an antagonist of HIF-1α
- activity to a patient having a condition associated with abnormally increased synovial cell density.
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12-20. -20. (canceled)
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21. A method of decreasing cartilage degradation in a joint comprising administering a therapeutically-effective amount of an antagonist of HIF-1α
- activity to a patient having a condition associated with an abnormally high rate of cartilage degradation.
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22-30. -30. (canceled)
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31. A method of decreasing IL-6 concentration in synovial tissue comprising administering a therapeutically effective amount of an antagonist of HIF-1α
- activity to a patient having a condition associated with an abnormally high concentration of IL-6 in synovial tissue.
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32-40. -40. (canceled)
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41. A method of manufacturing a drug for use in the treatment of rheumatoid arthritis comprising:
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(a) identifying a compound as useful in the treatment of rheumatoid arthritis by;
(i) comparing an amount of HIF-1α
activity in the presence of the compound with an amount HIF-1α
activity in the absence of the compound; and
(ii) identifying the compound as useful in the treatment of rheumatoid arthritis when the amount of HIF-1α
activity in the presence of the compound is lower than the amount of HIF-1α
activity in the absence of the compound; and
(b) formulating said compound for human consumption.
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42-80. -80. (canceled)
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81. A method identifying a compound useful in the treatment of rheumatoid arthritis, which method comprises:
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(a) comparing an amount of HIF-1α
activity in the presence of the compound with an amount HIF-1α
activity in the absence of the compound; and
(b) selecting the compound as useful in the treatment of rheumatoid arthritis when the amount of HIF-1α
activity in the presence of the compound is lower than the amount of HIF-1α
activity in the absence of the compound. - View Dependent Claims (82, 83, 84, 85, 86, 87, 89, 94, 103, 104, 108, 113, 118)
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88. (canceled)
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90-93. -93. (canceled)
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95-102. -102. (canceled)
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105-107. -107. (canceled)
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109-112. -112. (canceled)
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114-117. -117. (canceled)
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119-123. -123. (canceled)
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124. A method of alleviating at least one symptom of rheumatoid arthritis, comprising administering an antagonist of HIF-1α
- activity and an anti-rheumatic drug to a patient having rheumatoid arthritis.
- View Dependent Claims (125, 126, 127, 128, 129, 130)
Specification