IAP nucleobase oligomers and oligomeric complexes and uses thereof
First Claim
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1. A substantially pure nucleobase oligomer comprising a duplex comprising at least eight but no more than thirty consecutive nucleobases corresponding to XIAP (SEQ ID NO:
- 21), HIAP-1 (SEQ ID NO;
53), or HIAP-2 (SEQ ID NO;
47), wherein said duplex is capable of reducing expression of an IAP polypeptide in a cell.
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Abstract
The present invention provides nucleobase oligomers and oligomer complexes that inhibit expression of an IAP polypeptide, and methods for using them to induce apoptosis in a cell. The nucleobase oligomers and oligomer complexes of the present invention may also be used to form pharmaceutical compositions. The invention also features methods for enhancing apoptosis in a cell by administering a nucleobase oligomer or oligomer complex of the invention in combination with a chemotherapeutic or chemosensitizing agent.
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Citations
48 Claims
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1. A substantially pure nucleobase oligomer comprising a duplex comprising at least eight but no more than thirty consecutive nucleobases corresponding to XIAP (SEQ ID NO:
- 21), HIAP-1 (SEQ ID NO;
53), or HIAP-2 (SEQ ID NO;
47), wherein said duplex is capable of reducing expression of an IAP polypeptide in a cell. - View Dependent Claims (2, 3, 4, 5, 6, 22, 23, 24, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
- 21), HIAP-1 (SEQ ID NO;
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7. A nucleobase oligomeric complex comprising paired sense and antisense strands, wherein said complex comprises between eight and thirty consecutive nucleobases corresponding to a sequence of any one of XIAP (SEQ ID NO:
- 21), HIAP-1 (SEQ ID NO;
53), and HIAP-2 (SEQ ID NO;
47), and said complex is capable of reducing expression of an IAP polypeptide in a cell. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 25, 26, 27, 28, 29, 30)
- 21), HIAP-1 (SEQ ID NO;
Specification