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Prolonged administration of NMDA antagonist and safener drug to alter neuropathic pain condition

  • US 20050148673A1
  • Filed: 02/23/2003
  • Published: 07/07/2005
  • Est. Priority Date: 07/11/2002
  • Status: Abandoned Application
First Claim
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1. A method for treating chronic pain, comprising the steps of administering to a patient in need of such treatment:

  • a. at least one NMDA receptor antagonist drug, at a sustained dosage which is able to substantially reduce the patient'"'"'s chronic pain, and over a continuous period of time, wherein that dosage level over that period of time has been shown in previous human treatments to provide long-lasting relief from chronic pain even after administration of the NMDA receptor antagonist drug has been discontinued; and

    , b. at least one safener drug, at a concentration which has been shown, using in vivo animal tests, to reduce neurotoxic damage caused by potent NMDA receptor antagonist drugs in the absence of a safener drug.

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