Implantable medical device

• US 20050149169A1
• Filed: 10/27/2004
• Published: 07/07/2005
• Est. Priority Date: 04/08/2003
• Status: Abandoned Application

• Current Assignee: Biophan Technologies Incorporated
• Original Assignee: Biophan Technologies Incorporated
• Inventors: Wang, Xingwu, Greenwald, Howard J.
• Application Number:
  US10/974,412
• Publication Number:
  US 20050149169A1
• Time in Patent Office: Days
• US Class Current: 623/1.150
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2210/009 magnetic
• CPC Class Codes: A61L 29/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque

Abstract

An implantable medical device assembly that contains magnetic material with a saturation magnetization of at least about 0.15 Tesla and which has a direct current permeability at a static magnetic field value of 1.5 Tesla of at least 1.1. When the magnetic material and is simultaneously subjected to an alternating current electromagnetic field with a frequency of 64 megahertz and a static magnetic field of 1.5 Tesla, it has a magnetization of less than 100 electromagnetic units per cubic centimeter.

Claims

1. An implantable medical device assembly comprised of a medical device and magnetic material disposed over said medical device, wherein:

(a) said magnetic material has a saturation magnetization of at least about 0.15 Tesla,

(b) when said magnetic material is simultaneously subjected to an alternating current electromagnetic field with a frequency of 64 megaherrtz and a static magnetic field of 1.5 Tesla, it has a magnetization of less than 100 electromagnetic units per cubic centimeter, and

(c) said magnetic material has a direct current permeability at a static magnetic field value of 1.5 Tesla of at least 1.1.

2. The medical device assembly as recited in claim 1, wherein said magnetic material is nanomagnetic material.

3. The medical device assembly as recited in claim 2, wherein said medical device is a stent.

4. The medical device assembly as recited in claim 3, wherein said stent is a metallic stent.

5. The medical device assembly as recited in claim 4, wherein said magnetic material has a direct current permeability at a static field value of 1.5 Tesla of from about 1.1 to about 2.0.

6. The medical device assembly as recited in claim 4, wherein said nanomagnetic material is comprised of nanomagnetic particles with an average particle size of less than about 100 nanometers.

7. The medical device assembly as recited in claim 6, wherein the average particle size of said nanomagnetic particles is from about 3 to about 10 nanometers.

8. The medical device assembly as recited in claim 6, wherein said nanomagnetic particles have a coherence length of less than 100 nanometers.

9. The medical device assembly as recited in claim 6, wherein said nanomagnetic material has an average particle size of less than about 20 nanometers and a phase transition temperature of less than about 200 degrees Celsius.

10. The medical device assembly as recited in claim 6, wherein the average particle size of such nanomagnetic particles is less than about 15 nanometers.

11. The medical device assembly as recited in claim 6, wherein said particles of said nanomagnetic material have a squareness of from about 0.05 to about 1.0.

12. The medical device assembly as recited in claim 6, wherein said particles of said nanomagnetic material are at least triatomic, being comprised of a first distinct atom, a second distinct atom, and a third distinct atom.

13. The medical device assembly as recited in claim 12, wherein said first distinct atom is an atom selected from the group consisting of atoms of actinium, americium, berkelium, californium, cerium, chromium, cobalt, curium, dysprosium, einsteinium, erbium, europium, fermium, gadolinium, holmium, iron, lanthanum, lawrencium, lutetium, manganese, mendelevium, nickel, neodymium, neptunium, nobelium, plutonium, praseodymium, promethium, protactinium, samarium, terbium, thorium, thulium, uranium, and ytterbium, and mixtures thereof.

14. The medical device assembly as recited in claim 12, wherein said first distinct atom is a cobalt atom.

15. The medical device assembly as recited in claim 12, wherein said particles of nanomagnetic material are comprised of atoms of cobalt and atoms of iron.

16. The stent assembly as recited in claim 12, wherein said particles of nanomagnetic material are comprised of a said first distinct atom, said second distinct atom, said third distinct atom, and a fourth distinct atom.

17. The medical device assembly as recited in claim 16, wherein said particles of nanomagnetic material are comprised of a fifth distinct atom.

18. The medical device assembly as recited in claim 6, wherein said particles of nanomagnetic material have a squareness of from about 0.1 to about 0.9.

19. The medical device assembly as recited in claim 6, wherein said particles of nanomagnetic material have a squarenesss is from about 0.2 to about 0.8.

20. The medical device assembly as recited in claim 6, wherein said particles of nanomagnetic material have an average size of less of less than about 3 nanometers.

21. The medical device assembly as recited in claim 6, wherein said particles of nanomagnetic material have a phase transition temperature of less than 46 degrees Celsius.

22. The medical device assembly as recited in claim 6, wherein said particles of nanomagnetic material have a phase transition temperature of less than about 50 degrees Celsius.

23. The medical device assembly as recited in claim 6, wherein said particles of nanomagnetic material have a coercive force of from about 0.01 to about 5,000 Oersteds.

24. The medical device assembly as recited in claim 12, wherein said second distinct atom has a relative magnetic permeability of about 1.0.

25. The medical device assembly as recited in claim 24, wherein said second distinct atom is an atom selected from the group consisting of aluminum, antimony, barium, beryllium, boron, bismuth, calcium, gallium, germanium, gold, indium, lead, magnesium, palladium, platinum, silicon, silver, strontium, tantalum, tin, titanium, tungsten, yttrium, zirconium, magnesium, and zinc.

26. The medical device assembly as recited in claim 25, wherein said third distinct atom is an atom selected from the group consisting of argon, bromine, carbon, chlorine, fluorine, helium, helium, hydrogen, iodine, krypton, oxygen, neon, nitrogen, phosphorus, sulfur, and xenon.

27. The medical device assembly as recited in claim 26, wherein said third distinct atom is nitrogen.

28. The medical device assembly as recited in claim 27, wherein said nanomagnetic particles are comprised of atoms of oxygen.

29. The medical device assembly as recited in claim 28, wherein said nanomagnetic particles are comprised of atoms of iron.

30. The medical device assembly as recited in claim 28, wherein said nanomagnetic particles are comprised of atoms of cobalt.

31. The medical device assembly as recited in claim 6, wherein said nanomagnetic material is present in the form of a coating with a thickness of from about 400 to about 2000 nanometers.

32. The medical device assembly as recited in claim 31, wherein said coating has a thickness of from about 600 to about 1200 nanometers.

33. The medical device assembly as recited in claim 31, wherein said coating has a morphological density of at least about 98 percent.

34. The medical device assembly as recited in claim 31, wherein said coating has a morphological density of at least about 99 percent.

35. The medical device assembly as recited in claim 1, wherein said medical device is a metallic stent, wherein said metallic stent is comprised of an interior cavity and an exterior cavity, wherein biological matter is disposed within said interior cavity, and wherein, when such exterior surface is simultaneously subjected to an input alternating current electromagnetic field with a frequency of from about 1 megahertz to about 3 terahertz and a static magnetic field of from about 0.1 to about 30 Tesla, such input alternating current electromagnetic field contacts the biological matter and produces an output signal that is disposed outside of said exterior surface and that has a fixed phase relationship with the input signal, and wherein the ratio of the magnitude of said output signal that is disposed outside of said exterior surface to the magnitude of said input alternating current electromagnetic field is at least about 0.01.

36. The medical device assembly as recited in claim 35, wherein the ratio of the magnitude of said output signal that is disposed outside of said exterior surface to the magnitude of said input alternating current electromagnetic field is at least about 0.2.

37. The medical device assembly as recited in claim 35, wherein wherein said ratio of the magnitude of said output signal that is disposed outside of said exterior surface to the magnitude of said input alternating current electromagnetic field is at least about 0.3.

38. The medical device assembly as recited in claim 35, wherein nanomagnetic material is disposed over said metallic stent.

39. The medical device assembly as recited in claim 31, wherein said medical device is a stent.

40. The medical device assembly as recited in claim 39, wherein said coating of nanomagnetic material is disposed over said stent, and wherein said coating is comprised of a top half and a bottom half.

41. The medical device assembly as recited in claim 39, wherein said coating of nanomagnetic material is comprised of nanomagnetic particles, and wherein at least about 60 weight percent of said nanomagentic particles are disposed in said bottom half of said coating.

42. The medical device as recited in claim 40, wherein said coating of nanomagnetic material is comprised of dielectric material, and wherein at least 55 weight percent of said dielectric material is disposed in said top half of said coating.

43. The medical device assembly as recited in claim 6, wherein said nanomagnetic particles are comprised of iron atoms and aluminum atoms.

44. The medical device assembly as recited in claim 43, wherein said nanomagentic particles are comprised of less than about 50 weight percent of iron, by total weight of iron and aluminum.

45. The medical device assembly as recited in claim 43, wherein said nanomagentic particles are comprised of from about 5 to about 40 weight percent of iron, by total weight of iron and aluminum.

46. The medical device assembly as recited in claim 43, wherein said nanomagentic particles are comprised of from about 5 to about 30 weight percent of of iron, by total weight of iron and aluminum.

47. The medical device assembly as recited in claim 43, wherein said nanomagentic particles are comprised of from about 5 to about 20 weight percent of of iron, by total weight of iron and aluminum.

48. The medical device assembly as recited in claim 1, wherein said magnetic material has a direct current permeability at a static magnetic field of 3.0 Tesla of at least 1.1.

49. The medical device assembly as recited in claim 1, wherein said magnetic material has a direct current permeability at a static magnetic field of 1.5 Tesla of at least 1.2.

50. The medical device assembly as recited in claim 1, wherein said magnetic material has a direct current permeability at a static magnetic field of 1.5 Tesla of at least 1.3.

51. The medical device assembly as recited in claim 1 wherein, when said magnetic material is simultaneously subjected to an alternating current electromagnetic field with a frequency of 64 megaherrtz and a static magnetic field of 1.5 Tesla, it has a magnetization of less than 10 electromagnetic units per cubic centimeter.

52. The medical device assembly as recited in claim 1 wherein, when said magnetic material is simultaneously subjected to an alternating current electromagnetic field with a frequency of 64 megaherrtz and a static magnetic field of 1.5 Tesla, it has a magnetization of less than 5 electromagnetic units per cubic centimeter.

53. The medical device assembly as recited in claim 1 wherein, when said magnetic material is simultaneously subjected to an alternating current electromagnetic field with a frequency of 64 megaherrtz and a static magnetic field of 1.5 Tesla, it has a magnetization of less than 1 electromagnetic units per cubic centimeter.

54. The medical device assembly as recited in claim 31, wherein a via is disposed in said coating.

55. The medical device assembly as recited in claim 54, wherein said via is a conductive via.

56. The medical device assembly as recited in claim 31, wherein a via is contiguous with said coating.

57. The medical device assembly as recited in claim 56, wherein said via is a conductive via.

58. The medical device assembly as recited in claim 31, wherein said coating has a transmission factor of at least about 1.5.

59. The medical device assembly as recited in claim 31, wherein said coating has a transmission factor of at least about 2.0.