Method and apparatus for macromolecular delivery using a coated membrane
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Abstract
This invention relates to the delivery of medicines, macromolecules, or other treating materials to tissues and/or fluids that are to be injected or placed within a human or animal body. The invention describes a method of introducing a treating material to fluids ex corpora using a malleable fracture stabilization device with micropores for directed drug delivery (U.S. Pat. No. 5,466,262) into which a medicine has been incorporated, an apparatus for managing macromolecular distribution (U.S. Pat. No. 5,653,760) that has been coated with a treating material, or any surface to which has been affixed a treating material. The invention describes the use of a disposable housing that contains a semipermeable membrane to which a treating material has been affixed. The invention teaches the use of a dialysis membrane to which heparin or other anticoagulant has been affixed, thereby substantially preventing thrombosis on the membrane while limiting the amount of heparin that must be given systemically. Furthermore, the present invention provides a new and useful mechanism to deliver a treating material directly into the intravenous line from a pre-labeled vial, at a precise rate, and in a minimum volume of fluid. This invention can also be used to deliver treating materials directly to cells and tissues at a defined rate, while at the same time permitting small metabolites and other small toxins to wash away.
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Citations
35 Claims
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1-8. -8. (canceled)
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9. A device to provide the presentation of a treating material to fluids or tissues for use in human or veterinary medicine comprising:
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i) a layer of material that is minimally porous to macromolecules, having a first and second major surface, the first major surface being adapted to be placed adjacent to a tissue or fluid to be treated, a second major surface being adapted to be placed opposite to a tissue or fluid to be treated, the layer being capable of releasing at least one treating material in a unidirectional manner, the layer also being capable of restricting the through passage of at least one type of macromolecule there through and ii) a treating material bound to the first major surface of the layer. - View Dependent Claims (10, 11, 12, 13, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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14-17. -17. (canceled)
Specification