Adhesive laminates for rapid wound occlusion

• US 20050153090A1
• Filed: 01/10/2005
• Published: 07/14/2005
• Est. Priority Date: 01/08/2004
• Status: Active Grant

• Current Assignee: Rocky Mountain Biosystems, Inc.
• Original Assignee: Kevin S. Marchitto, Stephen T. Flock
• Inventors: Marchitto, Kevin S., Flock, Stephen T.
• Granted Patent: US 7,758,939 B2
• Time in Patent Office: Days
• US Class Current: 428/40.100
• CPC Class Codes: A61B 17/085 with adhesive layer
• CPC Class Codes: A61B 17/10 for applying or removing wound clamps, e.g. containing only one clamp or staple A61B17/076 takes precedence; containing multiple wound clamps A61B17/068; Wound clamp magazines containers, packaging elements or packages specially adapted for particular articles or with special means for dispensing contents B65D83/00, B65D85/00
• CPC Class Codes: A61B 17/105 Wound clamp magazines for packaging sharps A61B50/3001
• CPC Class Codes: A61F 13/023 wound covering film layers without a fluid retention layer
• CPC Class Codes: A61F 15/002 dispensers for web or tape like bandages
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: Y10T 156/12 Surface bonding means and/or assembly means with cutting, punching, piercing, severing or tearing
• CPC Class Codes: Y10T 428/14 Layer or component removable to expose adhesive
• CPC Class Codes: Y10T 428/1405 Capsule or particulate matter containing [e.g., sphere, flake, microballoon, etc.]
• CPC Class Codes: Y10T 428/1419 Wax containing
• CPC Class Codes: Y10T 428/1424 Halogen containing compound
• CPC Class Codes: Y10T 428/1429 Fluorine
• CPC Class Codes: Y10T 428/1471 Protective layer
• CPC Class Codes: Y10T 428/24273 including aperture
• CPC Class Codes: Y10T 428/2887 including nitrogen containing polymer [e.g., polyacrylonitrile, polymethacrylonitrile, etc.]
• CPC Class Codes: Y10T 428/31935 Ester, halide or nitrile of addition polymer

Abstract

Provided herein are protective laminate devices comprising a biocompatible non-adherent substance and a fast-setting adhesive and methods of use. Also provided is a dispenser for an adhesive tape. The protective laminate devices and methods may be used for wound closure.

Claims

1. A laminate device for protecting an adhesive during manipulation thereof, comprising:

said adhesive; and

at least one layer of a biocompatible non-adherent substance disposed in protective relationship to said adhesive.

2. The laminate device of claim 1, wherein said adhesive is cyanoacrylate or a derivative thereof, a protein or a synthetic polymer.

3. The laminate device of claim 1, wherein said adhesive is porous or permeable.

4. The laminate device of claim 1, wherein one or more layers of said biocompatible non-adherent substance further comprises an emulsifying agent, a solubilizing agent, a wetting agent, a taste modifying agent, a plasticizer, a bioactive agent, a water soluble inert filler, a preservative, a buffering agent, a coloring agent, a stabilizer, or a combination thereof.

5. The laminate device of claim 1, wherein one or more layers of said biocompatible non-adherent substance further comprises a pharmaceutical.

6. The laminate device of claim 5, wherein said pharmaceutical is contained within a rupturable reservoir within said layer(s).

7. The laminate device of claim 1, wherein the layer(s) of said biocompatible non-adherent substance is disposed on a surface of said adhesive or comprises said adhesive incorporated therein.

8. The laminate device of claim 7, wherein said adhesive is contained within a rupturable reservoir within one of said layer(s).

9. The laminate device of claim 1, wherein said biocompatible non-adherable protective substance dissolves upon contact with a fluid.

10. The laminate device of claim 9, wherein said fluid is water.

11. The laminate device of claim 1, wherein one or more layers of said biocompatible non-adherent substance comprises a hydrocolloid.

12. The laminate device of claim 11, wherein said hydrocolloid is pullulan.

13. The laminate device of claim 1, further comprising at least one removable layer disposed in contact with said adhesive, with one or more layers of said biocompatible non-adherent substance or a combination thereof.

14. The laminate device of claim 13, wherein the removable layer is disposed in contact with said adhesive, said removable layer removable prior to manipulation of said adhesive.

15. The laminate device of claim 13, wherein the removable layer is disposed between said adhesive and said biocompatible non-adherent substance or is disposed in covering relationship to an outer layer of said biocompatible non-adherent substance, said removable layer removable after manipulation of said adhesive.

16. The laminate device of claim 13, wherein said removable layer comprises teflon or a cellulose impregnated with a lipid.

17. The laminate device of claim 16, wherein said lipid is a lecithin, polyethylene glycol or a wax.

18. The laminate device of claim 1, wherein said device comprises a patch.

19. A method of preventing unintentional bonding of an adhesive during application thereof to one or more tissues, comprising:

positioning the laminate device of claim 1 onto the tissue(s) wherein the adhesive layer comprising said laminate device is in contact with said tissue(s);

activating said adhesive; and

removing a removable layer(s) further comprising said laminate device, wherein if the removable layer is disposed only on a surface of said adhesive layer, said removable layer is removed prior to positioning said laminate device or if the removable layer(s) is disposed on one or more layers of the biocompatible non-adherent substance comprising said laminate device, said removable layer(s) is removed after activating said adhesive or a combination thereof;

wherein said biocompatible non-adherent substance and said removable layer(s) protect said adhesive layer during application thereof thereby preventing unintentional bonding of said adhesive.

20. The method of claim 19, further comprising:

setting said adhesive to join said tissue(s).

21. The laminate device of claim 19, wherein said removable layer comprises teflon or a cellulose impregnated with a lipid.

22. The laminate device of claim 21, wherein said lipid is a lecithin, polyethylene glycol or a wax.

23. A method of delivering a bioactive agent to one or more tissues, comprising:

positioning the laminate device of claim 1 in contact with the tissue(s) wherein one or more of the layers of the laminate device comprises said bioactive agent thereby delivering said bioactive agent to the tissue(s).

24. The method of claim 23, wherein said bioactive agent is the adhesive comprising the layer in contact with the tissue(s), the method further comprising setting said adhesive to join the tissue(s).

25. The method of claim 24, wherein said adhesive is contained within a rupturable reservoir, the method further comprising rupturing the reservoir prior to setting said adhesive.

26. The method of claim 23, wherein said bioactive agent is a pharmaceutical comprising one or more of the layers disposed in protective relationship with a porous or permeable adhesive in contact with the tissue(s), the method further comprising diffusing the pharmaceutical therefrom through said porous or permeable adhesive layer.

27. The method of claim 26, wherein said pharmaceutical is contained within a rupturable reservoir within said layer(s), the method further comprising rupturing the reservoir prior to diffusing said pharmaceutical.

28. A dispenser for an adhesive tape, comprising:

a biocompatible non-adherent substance;

a means to dispense an adhesive layer onto a layer of said biocompatible non-adherent substance;

a means to cut said combined layers; and

a housing having an opening.

29. The dispenser of claim 28, wherein said biocompatible non-adherent substance dissolves upon contact with a fluid.

30. The dispenser of claim 28, wherein one or more layers of said biocompatible non-adherent substance comprises a hydrocolloid.

31. The dispenser of claim 28, wherein the layer of said biocompatible non-adherent substance further comprises an emulsifying agent, a solubilizing agent, a wetting agent, a taste modifying agent, a plasticizer, a bioactive agent, a water soluble inert filler, a preservative, a buffering agent, a coloring agent, a stabilizer, or a combination thereof.

32. The dispenser of claim 28, wherein said adhesive is cyanoacrylate or a derivative thereof, a protein or a synthetic polymer.

33. The dispenser of claim 28, wherein the means to dispense said adhesive comprises a brush impregnated with said adhesive.

34. The dispenser of claim 28, wherein the means to dispense said adhesive comprises:

a brush; and

an ampoule to contain said adhesive fluidly connected to said brush.

35. A method of forming an adhesive tape to join one or more tissues, comprising:

withdrawing a length of the layer of said biocompatible non-adherent substance through the opening in the dispensor of claim 28;

simultaneously dispensing the adhesive layer along the length of the layer of said biocompatible non-adherent substance via the brush in said dispenser; and

cutting the combined layers via the cutting means comprising said dispenser after sufficient length has been withdrawn thereby forming said adhesive tape.

36. The method of claim 35, further comprising:

positioning said adhesive tape on one or more tissues, said adhesive layer in contact with said tissue(s); and

setting said adhesive thereby joining said tissue(s).